Results 41 to 50 of about 14,529 (159)

Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model

Biological Research
Background Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine that serves as an endocrine signal
Muhammad Ameen Jamal, Yixiao Cheng, Deling Jiao, Wen Cheng, Di Zou, Xia Wang, Taiyun Wei, Jianxiong Guo, Kaixiang Xu, Heng Zhao, Shaoxia Pu, Chang Yang, Yubo Qing, Baoyu Jia, Honghui Li, Rusong Zhao, Hong-Ye Zhao, Hong-Jiang Wei   +17 more
doaj   +1 more source

Exploring the Anti‐Diabetic Potential of Anthocyanins: From Biochemical Pathways to Human Trials

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Diabetes mellitus (DM) is a global health challenge with increasing prevalence rates, particularly in low‐ and middle‐income countries. Anthocyanins (ACs) are potential bioactive compounds found in various fruits and vegetables, attracting the attention of researchers due to their possible role in managing diabetes and its complications ...
Lakshay Panchal, Sangeeta Yadav, Akash Kumar, Tanbeer Kaur, Yashna Bawa, Sarvesh Rustagi, Rahul Mehra   +6 more
wiley   +1 more source

Establishment of a donor pig for xenotransplantation clinical trials based on the principle of Changsha Communiqué

Health Care Science, 2023
Background Xenotransplantation is a potential way to reduce the shortage of the needed organ grafts for the end‐stage disease. Immune rejection, physiological incompatibility and bio‐safety are the most critical issues.
Xiaoqian Ma, Sang Li, Jia Wang, Chang Xu, Wei Wang   +4 more
doaj   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future

Cell Transplantation, 2017
Islet allotransplantation results in increasing success in treating type 1 diabetes, but the shortage of deceased human donor pancreata limits progress. Islet xenotransplantation, using pigs as a source of islets, is a promising approach to overcome this
Zhengzhao Liu, Wenbao Hu, Tian He, Yifan Dai, Hidetaka Hara, Rita Bottino, David K. C. Cooper, Zhiming Cai, Lisha Mou Ph.D.   +8 more
doaj   +1 more source

The Jewish Perspectives on Xenotransplantation

Rambam Maimonides Medical Journal, 2023
Xenotransplantation represents a viable solution to meet the great need to provide organ donors at a time when there are not enough human organ donors.
John D. Loike, Rabbi Moshe Krupka
doaj   +1 more source

Generation of RAG2 Knockout Immune-Deficient Miniature Pigs

Animals
Recombination-activating genes (RAGs) play a crucial role in the V(D)J recombination process and the development of immune cells. The development of the immune system and its mechanisms in pigs exhibit greater similarity to those of humans compared to ...
Jing Wang, Feiyan Zhu, Deling Jiao, Chang Yang, Junqi Wang, Fengchong Wang, Heng Zhao, Hong-Jiang Wei, Hong-Ye Zhao   +8 more
doaj   +1 more source

Data on B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy

Data in Brief, 2018
This report is related to the research article entitled “B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy” (Yamamoto et al., in press).
Takayuki Yamamoto, Qi Li, Hidetaka Hara, Liaoran Wang, Hongmin Zhou, Juan Li, Devin E. Eckhoff, A. Joseph Tector, Edwin C. Klein, Ray Lovingood, Mohamed Ezzelarab, David Ayares, Yi Wang, David K.C. Cooper, Hayato Iwase   +14 more
doaj   +1 more source

Gut microbiota and their metabolite profiles following peripheral nerve xenotransplantation

Heliyon, 2023
Background: Intestinal pathogens are associated with xenotransplantation tolerance and rejection. However, changes in the gut microbiota in patients who have undergone peripheral nerve xenotransplantation and their association with immune rejection have ...
Yongsheng Chen, Huihui Chai, Zhenzhen Li, Bin Liu, Minxuan Tan, Shaopeng Li, Yanxia Ma   +6 more
doaj   +1 more source

Progress in Xenotransplantation: Immunologic Barriers, Advances in Gene Editing, and Successful Tolerance Induction Strategies in Pig-To-Primate Transplantation

Frontiers in Immunology, 2022
Organ transplantation is the most effective treatment for end stage organ failure, but there are not enough organs to meet burgeoning demand. One potential solution to this organ shortage is xenotransplantation using pig tissues.
Daniel L. Eisenson, Daniel L. Eisenson, Yu Hisadome, Kazuhiko Yamada, Kazuhiko Yamada   +4 more
doaj   +1 more source