Results 41 to 50 of about 29,864 (273)
Kidney xenotransplantation [PDF]
Kidney International, 2014 Xenotransplantation using pigs as donors offers the possibility of eliminating the chronic shortage of donor kidneys, but there are several obstacles to be overcome before this goal can be achieved. Preclinical studies have shown that, while porcine renal xenografts are broadly compatible physiologically, they provoke a complex rejection process ...
Cowan, PJ, Cooper, DKC, d'Apice, AJF
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The history of cardiac xenotransplantation: early attempts, major advances, and current progress
Frontiers in Transplantation, 2023 In light of ongoing shortage of donor organs for transplantation, alternative sources for donor organ sources have been examined to address this supply-demand mismatch.
Nicholas R. Hess +2 more
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Frontiers in Immunology, 2022 Sda, produced by the B4GALNT2 enzyme, has been recognized as an important xenoantigen for pig-to-nonhuman primate xenotransplantation. However, little is known about Sda expression in pigs and its immunogenicity in xenotransplantation.
H. Feng +9 more
semanticscholar +1 more source
Tolerance in xenotransplantation [PDF]
Current Opinion in Organ Transplantation, 2017 This review describes recent progress in tolerance-inducing strategies across xenogeneic immunological barriers as well as the potential benefit of a tolerance strategy for islets and kidney xenotransplantation.Using advanced gene editing technologies, xenotransplantation from multitransgenic alpha-1,3-galactosyltransferase knockout pigs has ...
Kazuhiko Yamada +2 more
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World first pig‐to‐human cardiac xenotransplantation
Xenotransplantation, 2022 On January 7, 2022, in Baltimore, MD, USA, the XenoHeart team at the University of Maryland School of Medicine (UMSOM) led by Dr. Muhammad Mohiuddin (President Elect International Xenotransplantation Association [IXA]) and Dr.
W. Hawthorne
semanticscholar +1 more source
Reevaluating the Ethical Issues in Porcine‐to‐Human Heart Xenotransplantation
The Hastings center report, 2022 A major limiting factor with heart allotransplantation remains the availability of organs from deceased donors. Porcine heart xenotransplantation could serve as an alternative source of organs for patients with terminal heart failure.
H. Silverman, P. Odonkor
semanticscholar +1 more source
Frontiers in Immunology, 2021 BackgroundIn pig-to-baboon transplantation models, there is increasing evidence of systemic inflammation in xenograft recipients (SIXR) associated with pig xenograft failure.
Guoqiang Zhang +10 more
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Nature CommunicationsXenotransplantation represents a possible solution to the organ shortage crisis and is an imminent clinical reality with long-term xenograft survival in pig-to-nonhuman primate (NHP) heart and kidney large animal models, and short-term success in recent ...
Daniel L. Eisenson +21 more
semanticscholar +1 more source
Immunodepletion in Xenotransplantation [PDF]
Journal of Investigative Surgery, 1990 Xenograft transplantation is perhaps the most immunologically difficult problem in transplantation today. An overwhelming hyperacute rejection reaction (HAR) occurs within minutes of organ implantation. Preformed antibodies are thought to initiate this process. We used a pig-to-dog renal xenograft transplant model and investigated methods of decreasing
Shapiro, R +14 more
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Advances in Innate Immunity to Overcome Immune Rejection during Xenotransplantation
Cells, 2022 Transplantation is an effective approach for treating end-stage organ failure. There has been a long-standing interest in xenotransplantation as a means of increasing the number of available organs.
Tian-Yu Lu +6 more
doaj +1 more source