Results 61 to 70 of about 29,864 (273)

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source

The Jewish Perspectives on Xenotransplantation

Rambam Maimonides Medical Journal, 2023
Xenotransplantation represents a viable solution to meet the great need to provide organ donors at a time when there are not enough human organ donors.
John D. Loike, Rabbi Moshe Krupka
doaj   +1 more source

Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation

Xenotransplantation, 2021
Nephrotic syndrome is a common complication of pig‐to‐baboon kidney xenotransplantation (KXTx) that adversely affects outcomes. We have reported that upregulation of CD80 and down‐regulation of SMPDL‐3b in glomeruli have an important role in the ...
K. Takeuchi, Y. Ariyoshi, A. Shimizu, Y. Okumura, Gabriel Cara-Fuentes, Gabriela E Garcia, Thomas Pomposelli, Hironosuke Watanabe, Lennan K Boyd, Dilrukshi K. Ekanayake-Alper, D. Amarnath, M. Sykes, D. Sachs, Richard J. Johnson, Kazuhiko Yamada   +14 more
semanticscholar   +1 more source

A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic Leukemia

Advanced Science, EarlyView.
A self‐assembling nanotherapeutic strategy is designed—CD38‐PHD/G‐NPs, which released γ‐secretase inhibitor first, followed by adaptive dihydroartemisnin release in response to elevated reactive oxygen species levels. This controlled, sequential release strategy maximizes the synergistic anti‐leukemic efficacy of two agents with distinct mechanisms of ...
Ruinan Jia, Yang Liu, Jilong Xiao, Yuan Xia, Xin Zhao, Huixian Ma, Jingjing Ye, Zhiyue Zhang, Tao Sun, Chunyan Ji   +9 more
wiley   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model

Biological Research
Background Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine that serves as an endocrine signal
Muhammad Ameen Jamal, Yixiao Cheng, Deling Jiao, Wen Cheng, Di Zou, Xia Wang, Taiyun Wei, Jianxiong Guo, Kaixiang Xu, Heng Zhao, Shaoxia Pu, Chang Yang, Yubo Qing, Baoyu Jia, Honghui Li, Rusong Zhao, Hong-Ye Zhao, Hong-Jiang Wei   +17 more
doaj   +1 more source

Induction of diabetes in cynomolgus monkey with one shot of analytical grade streptozotocin

Animal Models and Experimental Medicine, 2020
Backgrounds Streptozotocin (STZ)‐ induced diabetic monkey is a wide used preclinical animal model for the investigation of diabetes such as islet transplantation and development of diabetic drugs.
Zhengzhao Liu, Ying Lu, Wenbao Hu, Hidetaka Hara, Yifan Dai, Zhiming Cai, Lisha Mou   +6 more
doaj   +1 more source

Animal models of lung cancer: Phenotypic comparison of different animal models of lung cancer and their application in the study of mechanisms

Animal Models and Experimental Medicine, EarlyView.
Grafts used to construct lung cancer animal models come from various sources, primarily cell lines, patient‐derived tumor tissues, and circulating tumor cells. Based on the sources of grafts and research objectives, lung cancer animal models can be categorized into several types: chemical‐induced models, orthotopic transplantation models, heterotopic ...
Zixuan Yang, Xianbin Zhao, Lili Tan, Pingxinyi Que, Tong Zhao, Wei Huang, Dejiao Yao, Songqi Tang   +7 more
wiley   +1 more source

Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future

Cell Transplantation, 2017
Islet allotransplantation results in increasing success in treating type 1 diabetes, but the shortage of deceased human donor pancreata limits progress. Islet xenotransplantation, using pigs as a source of islets, is a promising approach to overcome this
Zhengzhao Liu, Wenbao Hu, Tian He, Yifan Dai, Hidetaka Hara, Rita Bottino, David K. C. Cooper, Zhiming Cai, Lisha Mou Ph.D.   +8 more
doaj   +1 more source

Establishment of a donor pig for xenotransplantation clinical trials based on the principle of Changsha Communiqué

Health Care Science, 2023
Background Xenotransplantation is a potential way to reduce the shortage of the needed organ grafts for the end‐stage disease. Immune rejection, physiological incompatibility and bio‐safety are the most critical issues.
Xiaoqian Ma, Sang Li, Jia Wang, Chang Xu, Wei Wang   +4 more
doaj   +1 more source