Results 71 to 80 of about 14,529 (159)

Mitigating Cross-Species Viral Infections in Xenotransplantation: Progress, Strategies, and Clinical Outlook

Cell Transplantation
Xenotransplantation holds great promise as a solution to address the critical shortage of organs, but it raises concerns regarding the potential transmission of porcine viruses to recipients, leading to infections and even zoonotic diseases. Data used in
Yenong Zhou, Shuyu Zhou, Qian Wang, Bing Zhang   +3 more
doaj   +1 more source

Clinical Islet Xenotransplantation: Development of Isolation Protocol, Anti-Rejection Strategies, and Clinical Outcomes

Cells
Allogeneic islet transplantation has become a standard therapy for unstable type 1 diabetes. However, considering the large number of type 1 diabetic patients, the shortage of donors is a serious issue.
Shinichi Matsumoto, Kyohei Matsumoto
doaj   +1 more source

Moral approval of xenotransplantation in Egypt: associations with religion, attitudes towards animals and demographic factors

BMC Medical Ethics
Xenotransplantation has great potential as an alternative to alleviate the shortage of organs for donation. However, given that the animal most suited for xenotransplantation is the pig, there are concerns that people in Muslim countries may be more ...
Gabriel Andrade, Eid AboHamza, Yasmeen Elsantil, AlaaEldin Ayoub, Dalia Bedewy   +4 more
doaj   +1 more source

The Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation

Journal of Immunology Research, 2017
Pig-to-human xenotransplantation offers a potential bridge to the growing disparity between patients with end-stage organ failure and graft availability.
Kannan P. Samy, James R. Butler, Ping Li, David K. C. Cooper, Burcin Ekser   +4 more
doaj   +1 more source

Clinical xenotransplantation

Japanese Journal of Clinical Immunology, 2007
The growing numerical gap between the number of patients and available human donor organs have led to a revival interest in xenotransplantation. This review will mainly focus on the clinical affairs of xenotransplantation and the project of producing the gene modified pigs.
openaire   +2 more sources

Donor pigs for clinical islet xenotransplantation: Review and future directions

Cell Transplantation
Allogeneic islet transplantation becomes a viable option for patients with unstable type 1 diabetes. However, considering the huge number of patients with type 1 diabetes, human donor shortage is a serious issue.
Shinichi Matsumoto, Sadaki Asari, Yoshihide Nanno, Hiroyuki Nakamura, Taisuke Okawa, Takumi Fukumoto   +5 more
doaj   +1 more source

Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage

Journal of Translational Medicine
The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising option due to the greater availability of donor organs.
Yinglin Yuan, Yuanyuan Cui, Dayue Zhao, Yuan Yuan, Yanshuang Zhao, Danni Li, Xiaomei Jiang, Gaoping Zhao   +7 more
doaj   +1 more source

Infection in xenotransplantation

BMJ, 2000
Advances in transplantation immunology have enhanced the possibility of xenotransplantation as a therapeutic option for end-stage organ failure. The potential spread of animal-derived pathogens to the recipient and to the general population, termed "xenosis," is a potential complication of interspecies transplantation.
openaire   +4 more sources

A Remarkable Journey of Porcine to Human Xenotransplantation

Indian Journal of Transplantation
Xenotransplantation of pig hearts offers a potential solution to the scarcity of available human organs for transplantation. This abstract explores the challenges and risks associated with xenotransplantation, as well as the ongoing research and ...
Dhruva Sharma, Krishnan Ganapathy Subramaniam   +1 more
doaj   +1 more source

Profound thrombocytopenia associated with administration of multiple anti‐inflammatory agents in baboons

Immunity, Inflammation and Disease, 2022
Mohamed H. Bikhet, Christophe Hansen‐Estruch, Mariyam Javed, Dalis E. Collins, Jeremy B. Foote, David Ayares, Hidetaka Hara, David K. C. Cooper   +7 more
doaj   +1 more source