Results 81 to 90 of about 29,864 (273)

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart

European Journal of Heart Failure, EarlyView.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout   +22 more
wiley   +1 more source

Minimizing Ischemia Reperfusion Injury in Xenotransplantation

Frontiers in Immunology, 2021
The recent dramatic advances in preventing “initial xenograft dysfunction” in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac ...
Parth M. Patel, M. Connolly, Taylor M. Coe, A. Calhoun, F. Pollok, J. Markmann, L. Burdorf, A. Azimzadeh, J. Madsen, R. Pierson   +9 more
semanticscholar   +1 more source

Cold non‐ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig‐to‐baboon xenotransplantation

Xenotransplantation, 2020
Successful preclinical transplantations of porcine hearts into baboon recipients are required before commencing clinical trials. Despite years of research, over half of the orthotopic cardiac xenografts were lost during the first 48 hours after ...
M. Längin, B. Reichart, S. Steen, T. Sjöberg, A. Paskevicius, Qiuming Liao, G. Qin, M. Mokelke, T. Mayr, J. Radan, Lara Issl, I. Buttgereit, Jiawei Ying, Ann Kathrin Fresch, A. Panelli, Stefanie Egerer, A. Bähr, B. Kessler, Anastasia Milusev, R. Sfriso, R. Rieben, D. Ayares, P. J. Murray, R. Ellgass, C. Walz, N. Klymiuk, E. Wolf, J. Abicht, P. Brenner   +28 more
semanticscholar   +1 more source

Xenotransplantation

, 2011
The above statement was made by Guido Persijn, former Medical Director of the Eurotransplant Foundation, an international organisation that coordinates organ donation and transplantation. Xenotransplantation is the transplantation of organs, tissues or cells from one species of animal to another.
Tramper, Johannes, Zhu, Yang
openaire   +1 more source

Mesoporous Semi‐Permeable Flexible Polyurethane Membranes: Advancing Bioartificial Pancreas Design for Type 1 Diabetes Treatment

Macromolecular Rapid Communications, EarlyView.
Elastomeric mesoporous membranes are developed for the elaboration of a bioartificial pancreas for type 1 diabetes treatment. Using green‐electrospinning followed by thermal and washing post‐treatments, the membranes achieve ≈20 nm pore sizes, biocompatibility, and mechanical strength and flexibility.
Bryan Gross, Emeline Lobry, Séverine Sigrist, Elisa Maillard, Jordan Magisson, Charles‐Thibault Burcez, Manuel Pires, Anne Hébraud, Guy Schlatter   +8 more
wiley   +1 more source

Future Systems of Xenotransplantation: Melding Historical and Bioethical Methodology

Cell Transplantation, 2023
The future of xenotransplantation is promising. However, the scientific process behind xenotransplantation, shown through the methodology of history and bioethics, involves stakeholders beyond the laboratory. We present three short vignettes, the history
Adam Negri, Lauren Wilson
doaj   +1 more source

The case for xenotransplantation [PDF]

Clinical Transplantation, 2015
AbstractThe availability of organs and cells from deceased humans for transplantation is not meeting the demand. Xenotransplantation, specifically the transplantation of organs and cells from genetically engineered pigs, could resolve this problem. Diabetic monkeys have remained normoglycemic and insulin‐independent after pig islet transplantation for &
openaire   +2 more sources

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

Neuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng, Min Bai, Changsheng Ma, Bo Han, Mengyuan Duan, Liying Zhang, Jinfen Guo, Changku Shi, Ke Li, Maotao He   +9 more
wiley   +1 more source

Cystathionine gamma‐lyase‐mediated hypoxia inducible factor 1‐alpha expression drives clear cell ovarian cancer progression

The Journal of Pathology, EarlyView.
Abstract Clear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%–11% of ovarian cancers in North America. Late‐stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, a challenge that has seen limited progress in recent decades.
Amal M EL‐Naggar, Yuqin Li, Busra Turgu, Yuchen Ding, Longyijie Wei, Shary Yuting Chen, Genny Trigo‐Gonzalez, Forouh Kalantari, Rodrigo Vallejos, Branden Lynch, Janine Senz, Amy Lum, J Maxwell Douglas, Clara Salamanca, Shelby Thornton, Yimei Qin, Kiran Parmar, Sandra E Spencer, Samuel Leung, Michelle MM Woo, Paul J Yong, Hai‐Feng Zhang, Christopher S Hughes, Gian Luca Negri, Yemin Wang, Gregg B Morin, Poul H Sorensen, David G Huntsman   +27 more
wiley   +1 more source

Dysfunction of Complementarity Determining Region 1 Encoded by T Cell Receptor Beta Variable Gene Is Potentially Associated with African Swine Fever Virus Infection in Pigs

Microorganisms
The beta T-cell receptor (TRB) expressed by beta T cells is essential for foreign antigen recognition. The TRB locus contains a TRBV family that encodes three complementarity determining regions (CDRs).
Jiayu Li, Huiyan Xing, Kai Liu, Ninglin Fan, Kaixiang Xu, Heng Zhao, Deling Jiao, Taiyun Wei, Wenjie Cheng, Jianxiong Guo, Xiong Zhang, Feiyan Zhu, Zhigao Bu, Dongming Zhao, Wen Wang, Hong-Jiang Wei   +15 more
doaj   +1 more source