Results 191 to 200 of about 16,717 (221)

Xist and X chromosome inactivation

Molecular and Cellular Endocrinology, 1998
X inactivation acts in female mammals to equalise X-linked gene dosage between XX females and XY males. X inactivation is controlled by a single X-linked cis-acting locus called the X inactivation centre (Xic). In 1991 the Xist gene was identified as a candidate for the Xic. Xist is expressed in all adult female tissues, but only from the allele on the
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X chromosome inactivation and the Xist gene

Cellular and Molecular Life Sciences (CMLS), 1998
Recent years have seen rapid progress towards understanding the molecular mechanisms involved in X chromosome inactivation (X inactivation). This progress has largely revolved around the discovery of the X inactive specific transcript (Xist) gene, which is known now to represent the master switch locus regulating X inactivation.
N, Brockdorff, S M, Duthie
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The Ambivalent Role of lncRNA Xist in Carcinogenesis

Stem Cell Reviews and Reports, 2019
Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice.
Yung-Kang, Chen, Yun, Yen
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Counting on Xist

Nature Genetics, 1998
Laura Carrel, Huntington F. Willard
openaire   +1 more source

Xist

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
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Xist seeds X inactivation

Nature Cell Biology, 2021
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Combination of human and mouse XIST domains generates a minimal functional XIST

X-chromosome inactivation (XCI) is an essential process in eutherian mammals to compensate dosage between females and males. XCI is triggered by XIST, a long non-coding RNA that acts as a scaffold for the recruitment of the needed heterochromatic changes to keep one X chromosome inactivated.
openaire   +1 more source

Xist nucleates local protein gradients to propagate silencing across the X chromosome

Cell, 2021
Yolanda Markaki, Iris Dror, Kathrin Plath   +2 more
exaly  

Xist Locus

2013
S.M. Gartler, M.A. Goldman
openaire   +1 more source

Long non-coding RNA XIST contributes to osteoarthritis progression via miR-149-5p/DNMT3A axis

Biomedicine and Pharmacotherapy, 2020
Jia Zheng, Yunke Liu
exaly