Results 71 to 80 of about 35,510 (301)
Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia [PDF]
, 2015 Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation.
Ballarino, Monica +2 more
core +2 more sources
AnXist-dependent protein assembly mediatesXistlocalization and gene silencing [PDF]
, 2020 SummaryNuclear compartments play diverse roles in regulating gene expression, yet the molecular forces and components driving compartment formation are not well understood. Studying how the lncRNAXistestablishes the inactive-X-chromosome (Xi)-compartment, we found that theXistRNA-binding-proteins PTBP1, MATR3, TDP43, and CELF1 form a condensate to ...
Pandya-Jones, Amy +16 more
openaire +1 more source
Nature Communications, 2022 X chromosome inactivation (XCI) is a dosage compensation phenomenon that occurs in females. Initiation of XCI depends on Xist RNA, which triggers silencing of one of the two X chromosomes, except for XCI escape genes that continue to be biallelically ...
Tianqi Yang, Jianhong Ou, E. Yildirim
semanticscholar +1 more source
Cellular Physiology and Biochemistry, 2017 Background/Aims: Long non-coding RNAs (lncRNAs) are key players in the development and progression of human cancers. The lncRNA XIST (X-inactive specific transcript) has been shown to be upregulated in human non-small cell lung cancer (NSCLC); however ...
Haoyou Wang +8 more
doaj +1 more source
Differentiation-dependent Requirement of Tsix long non-coding RNA in Imprinted X-chromosome Inactivation [PDF]
, 2014 Imprinted X-inactivation is a paradigm of mammalian transgenerational epigenetic regulation resulting in silencing of genes on the paternally-inherited X-chromosome.
Buttigieg, Emily +8 more
core +1 more source
XIST lost induces ovarian cancer stem cells to acquire taxol resistance via a KMT2C-dependent way
Cancer Cell International, 2020 Background/aims The expression levels of long non-coding RNA XIST are significantly associated with paclitaxel (Pac) sensitivity in ovarian cancer, but the mechanism of action remains unclear.
Ruili Huang, Lijuan Zhu, Yali Zhang
doaj +1 more source
Molecular Medicine, 2021 Background Long non-coding RNA (lncRNA) XIST has been implicated in the progression of a variety of tumor diseases. The purpose of this study was to explore the molecular role of lncRNA XIST in human hepatitis B virus (HBV)-related hepatocellular ...
Jiancheng Wang +10 more
doaj +1 more source
Cell Death Discovery, 2022 Burn injuries are a serious threat to quality of life. The aim of this study was to investigate the mechanism of burn wound healing. The lncRNA XIST has been associated with burn wound healing, but the mechanism is not clear.
Liya Pi, B. Fang, Xianxi Meng, Lili Qian
semanticscholar +1 more source
Xist expression from an Xist YAC transgene carried on the mouse Y chromosome [PDF]
Human Molecular Genetics, 1996 We have constructed mouse transgenic lines carrying a YAC clone encompassing the Xist gene in order to investigate the factors influencing Xist expression and the initiation of X-inactivation. Two transgenic lines were derived, one carrying four copies integrated at an autosomal site and a second line carrying four copies integrated at a single site on
S, Matsuura +3 more
openaire +2 more sources
Epigenetics, 2019 XIST, in association with the shorter ncRNA RepA, are essential for the initiation of X chromosome inactivation (XCI) in mice. The molecular mechanisms controlling XIST and RepA expression are well characterized in that specie.
Anelise Dos Santos Mendonça +6 more
doaj +1 more source