Results 81 to 90 of about 35,510 (301)

Trisomy silencing by XIST: translational prospects and challenges

Human Genetics
XIST RNA is heavily studied for its role in fundamental epigenetics and X-chromosome inactivation; however, the translational potential of this singular RNA has been much less explored.
Khusali Gupta, Jan T. Czerminski, Jeanne B. Lawrence   +2 more
semanticscholar   +1 more source

Bayesian Decision Theory and Stochastic Independence [PDF]

, 2020
As stochastic independence is essential to the mathematical development of probability theory, it seems that any foundational work on probability should be able to account for this property. Bayesian decision theory appears to be wanting in this respect.
Mongin, Philippe
core  

Bayesian Decision Theory and Stochastic Independence [PDF]

, 2017
Stochastic independence has a complex status in probability theory. It is not part of the definition of a probability measure, but it is nonetheless an essential property for the mathematical development of this theory.
Mongin, Philippe
core   +2 more sources

LncRNA XIST is involved in rheumatoid arthritis fibroblast-like synoviocytes by sponging miR-126-3p via the NF-κB pathway

Autoimmunity, 2021
The role and mechanism of lncRNA XIST (XIST) in the development of rheumatoid arthritis (RA) was explored in this study. RT-qPCRs were performed to detect the expression of XIST and miR-126-3p in synovial tissues and cells.
Wei Liu, Jing Song, Xingyu Feng, Haolong Yang, Wei Zhong   +4 more
doaj   +1 more source

Escape from X inactivation is directly modulated by levels of Xist non-coding RNA

bioRxiv
In placental females, one copy of the two X chromosomes is largely silenced during a narrow developmental time window, in a process mediated by the non-coding RNA Xist 1.
Antonia Hauth, Jasper Panten, Emma Kneuss, Christel Picard, N. Servant, Isabell Rall, Yuvia A. Pérez-Rico, Lena Clerquin, N. Servaas, L. Villacorta, Ferris Jung, Christy Luong, Howard Y. Chang, Judith B. Zaugg, O. Stegle, D. T. Odom, Agnese Loda, Edith Heard   +17 more
semanticscholar   +1 more source

The how and why of lncRNA function: An innate immune perspective. [PDF]

, 2020
Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts.
Carpenter, Susan, Covarrubias, Sergio, Robinson, Elektra K   +2 more
core  

Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes [PDF]

, 2015
Fluorescence in situ hybridization (FISH) is a powerful single-cell technique for studying nuclear structure and organization. Here we report two advances in FISH-based imaging.
Avendano, M., Bantignies, F., Beliveau, B., Boettiger, A., Colognori, D., Erceg, J., Fonseka, C., Hannan, M., Hoang, H., Joyce, E., Jungmann, R., Kim-Kiselak, C., Lee, J., McCole, R., Shih, W., Wu, C., Yin, P., Zhuang, X.   +17 more
core   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Mesenchymal stem cells overexpressing XIST induce macrophage M2 polarization and improve neural stem cell homeostatic microenvironment, alleviating spinal cord injury

Journal of Tissue Engineering
Spinal cord injury (SCI) is a significant cause of disability worldwide, with limited treatment options. This study investigated the potential of bone marrow-derived mesenchymal stem cells (BMSCs) modified with XIST lentiviral vector to modulate ...
Dan Zhu, Tie Peng, Zhenwang Zhang, Shuang Guo, Ying Su, Kangwei Zhang, Jiawei Wang, Chao Liu   +7 more
semanticscholar   +1 more source

Progress toward understanding chromosome silencing by Xist RNA

Genes & Development, 2020
In this review, Brockdorff et al. discuss progress toward determining the role of newly defined factors in establishing features of Xi chromatin and in gene silencing by Xist RNA, including a summary of the current understanding of their relative ...
N. Brockdorff, Joseph S. Bowness, Guifeng Wei   +2 more
semanticscholar   +1 more source