Results 121 to 130 of about 9,747 (200)
Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. [PDF]
, 2015 Thermal exposure is a serious and growing challenge facing fish species worldwide. Chinook salmon (Oncorhynchus tshawytscha) living in the southern portion of their native range are particularly likely to encounter warmer water due to a confluence of ...
Baerwald, Melinda R +6 more
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XPO1/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting
BiomoleculesExportin 1 is responsible for the export of hundreds of proteins, several RNA species and ribosomal components from the nucleus to the cytoplasm. Several transported proteins are important for regulation of cell proliferation and survival both in normal and malignant cells.
Øystein Bruserud +3 more
openaire +4 more sources
Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model. [PDF]
, 2019 Human non‑small cell lung cancer (NSCLC) is associated with an extremely poor prognosis especially for the 40% of patients who develop brain metastasis, and few treatment strategies exist.
Hsu, Ping-Chih +9 more
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Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma
EBioMedicine, 2015 Infection with HIV ultimately leads to advanced immunodeficiency resulting in an increased incidence of cancer. For example primary effusion lymphoma (PEL) is an aggressive non-Hodgkin lymphoma with very poor prognosis that typically affects HIV infected
Eline Boons +13 more
doaj +1 more source
The Application of Clinical GeneticsGabriela Ręka, Katarzyna Wojciechowska, Monika Lejman Independent Laboratory of Genetic Diagnostics of the Second Chair of Pediatrics, Medical University of Lublin, Lublin, PolandCorrespondence: Gabriela Ręka, Independent Laboratory of ...
Ręka G, Wojciechowska K, Lejman M
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Hold on to your friends: dedicated chaperones of ribosomal proteins [PDF]
, 2017 Eukaryotic ribosomes are assembled from their components, the ribosomal RNAs and ribosomal proteins, in a tremendously complex, multi-step process, which primarily takes place in the nuclear compartment.
Kressler, Dieter +3 more
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The effect of aberrant expression and genetic polymorphisms of Rad21 on cervical cancer biology
Cancer Medicine, 2018 The therapeutic challenge of advanced, recurrent, and refractory cervical cancer (CC) needs to develop new molecularly targeted drugs. Rad21 is an important regulatory gene that maintains the correct dissociation of sister chromatids during cell mitosis.
Li Xia +5 more
doaj +1 more source
Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung Cancer
Advanced ScienceImmunotherapy has gained approval for use in small cell lung cancer (SCLC), yet only a subset of patients (10–20%) experience meaningful benefits, underscoring the urgent need for more effective therapeutic approaches.
Tingting Qin +14 more
doaj +1 more source
XPO1抑制剂KPT-8602对U937细胞增殖和凋亡的影响
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 目的】探讨核输出蛋白（XPO1）选择性抑制剂KPT-8602对人组织细胞淋巴瘤细胞系U937细胞增殖、周期、凋亡的影响及其可能的机制研究。【方法】以U937细胞为研究对象，给予不同浓度的KPT-8602处理细胞后，CCK-8法检测细胞活力；流式细胞术检测细胞周期及凋亡；Westernblot法检测XPO1、p-AKT、AKT、CleavedCaspase-3、p21的表达情况；荧光显微镜观察XPO1的亚细胞定位。【结果】CCK-8结果显示KPT-8602可抑制U937细胞的活力，在一定范围内具有剂量 ...
肖晓慧 +7 more
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