Results 131 to 140 of about 9,747 (200)

XPO1 Gene Mutation [PDF]

, 2020
openaire   +1 more source

XPO1 wt Allele [PDF]

, 2020
openaire   +1 more source

NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation

Leukemia
Abstract Nucleophosmin ( NPM1 ) is a nucleolar protein and one of the most frequently mutated genes in acute myeloid leukemia (AML). In addition to the commonly detected frameshift mutations in exon12 (NPM1c), previous studies have identified NPM1
Yuko Shimosato, Keita Yamamoto, Yuhan Jia, Wenyu Zhang, Norio Shiba, Yasuhide Hayashi, Shuichi Ito, Toshio Kitamura, Susumu Goyama   +8 more
openaire   +2 more sources

Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin

Communications Biology
Wilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients with favorable histology WT (FHWT). Half of these patients will succumb to their disease.
Karuna Mittal, Garrett W. Cooper, Benjamin P. Lee, Yongdong Su, Katie T. Skinner, Jenny Shim, Hunter C. Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D. Kynnap, Amanda L. Christie, Xiaoping Yang, Glenn S. Cowley, Brittaney A. Leeper, Christopher L. Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M. Clinton, Manoj Bhasin, Brian D. Crompton, Yuen-Yi Tseng, Jesse S. Boehm, Keith L. Ligon, David E. Root, Andrew J. Murphy, David M. Weinstock, Prafulla C. Gokhale, Jennifer M. Spangle, Miguel N. Rivera, Elizabeth A. Mullen, Kimberly Stegmaier, Kelly C. Goldsmith, William C. Hahn, Andrew L. Hong   +37 more
doaj   +1 more source

XPO1 Inhibitor SL-801 [PDF]

, 2020
openaire   +1 more source

Efficacy of an XPO1 inhibitor in combination with irinotecan in a preclinical colorectal cancer model. [PDF]

Front Oncol
Lentz RW, Dominguez ATA, Balmaceda NB, Arcaroli JJ, Bagby SM, Binns CA, Smoots SG, Jackson MM, Macbeth M, Holmstoen T, Banerjee T, Whitty PA, Yi SS, Lieu CH, Messersmith WA, Pitts TM.   +15 more
europepmc   +1 more source

A Unified Model: Chromatin-Bound Multicomponent Condensates. [PDF]

Cancer Res
Lau BK, Haarer EL, Ahn JH, Wang GG.
europepmc   +1 more source

Oral selinexor–dexamethasone for triple-class refractory multiple myeloma [PDF]

, 2019
al., et, Vij, Ravi
core   +1 more source

Kronik Lenfositik Lösemide NOTCH1 ve XPO1 genlerindeki Varyasyonların araştırılması

, 2019
66
openaire   +4 more sources

Allosteric degraders induce CRL5 ASB8 mediated degradation of XPO1.

bioRxiv : the preprint server for biology
The nuclear export receptor Exportin 1 (XPO1/CRM1) is often overexpressed in cancer cells resulting in aberrant localization of many cancer-related protein cargoes. The XPO1 inhibitor and cancer drug selinexor (KPT-330), and its analog KPT-185, block XPO1-cargo binding thereby restoring cargo localization.
Hudman-Wing, Casey Elizabeth, Fung, Ho Yee Joyce, Cagatay, Tolga, Kwanten, Bert, Niesman, Ashley B., Gharghabi, Mehdi, Permentier, Brecht, Shakya, Binita, Shacham, Sharon, Landesman, Yosef, Lapalombella, Rosa, Daelemans, Dirk, Chook, Yuh Min   +12 more
openaire   +2 more sources