Results 131 to 140 of about 5,881 (166)

NUP214 in Acute Myeloid Leukemia. [PDF]

Cells
Bruserud Ø, Reikvam H.
europepmc   +1 more source

Refining the role of selinexor in multiple myeloma: strategic use in a shifting treatment landscape. [PDF]

ESMO Open
Gay F, Buda G, Petrucci MT, Bolli N, Cea M, Derudas D, Mangiacavalli S, Montefusco V, Antonioli E, Barilà G, Basso M, Bertazzoni P, Bertuglia G, Bianco R, Carlisi M, Giudice MLD, Della Pepa R, Fazio F, Franceschini L, Furlan A, Gozzetti A, Liberatore C, Mancuso K, Martino EA, Mele G, Monaco F, Morè S, Paris L, Pavan L, Pezzatti S, Rago A, Ribolla R, Roncato R, Rossini B, Sgherza N, Vassallo F, Vincelli DI, Za T, Musto P, Zamagni E.   +39 more
europepmc   +1 more source

Circ-XPO1 upregulates XPO1 expression by sponging multiple miRNAs to facilitate osteosarcoma cell progression

Experimental and Molecular Pathology, 2020
Circular RNAs (circRNAs) act as a key role in mediating carcinogenesis. Nevertheless, the functions and mechanisms of circRNAs in osteosarcoma (OS) are still not fully understood. In the present study, we aim to investigate the functions of circ-XPO1 in OS and its potential mechanism underlying OS progression.
Lei Shen, Yang Jiang, Yongtao Li
exaly   +3 more sources

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Targeting XPO1-Dependent Nuclear Export in Cancer

Biochemistry (Moscow), 2022
Nucleocytoplasmic transport of macromolecules is tightly regulated in eukaryotic cells. XPO1 is a transport factor responsible for the nuclear export of several hundred protein and RNA substrates. Elevated levels of XPO1 and recurrent mutations have been reported in multiple cancers and linked to advanced disease stage and poor survival.
Alexey V Sorokin, Sorokin Alexey, Kim Ekaterina   +2 more
exaly   +3 more sources

XPO1 Expression Is a Poor-Prognosis Marker in Pancreatic Adenocarcinoma [PDF]

Journal of Clinical Medicine, 2019
Pancreatic adenocarcinoma (PAC) is one of the most aggressive human cancers and new systemic therapies are urgently needed. Exportin-1 (XPO1), which is a member of the importin-β superfamily of karyopherins, is the major exporter of many tumor suppressor proteins that are involved in the progression of PAC.
Daniel Birnbaum, François Bertucci, Emilie Mamessier   +2 more
exaly   +4 more sources

Prognostic and therapeutic significance of XPO1 in T-cell lymphoma

Experimental Cell Research, 2022
T-cell lymphoma (TCL) is a highly heterogeneous group of invasive non-Hodgkin lymphoma with adverse prognosis and limited treatment options. The relationship between TCL and Exportin-1 (XPO1), a major nuclear export receptor, has not been established yet. We here investigated the prognostic role and therapeutic implication of XPO1 in TCL.
Danian Nie, Yiqing Li
exaly   +3 more sources

Redirecting traffic using the XPO1 police

Blood, 2013
In this issue of Blood, Walker et al investigate the preclinical potential of KPT-330, an exportin-1 (XPO1, also known as chromosome maintenance protein 1 [CRM1]) inhibitor, against both accelerated phase (AP) and blast crisis chronic myeloid leukemia (CML-BC) and against Philadelphia chromosome-positive (Ph1) acute lymphoblastic leukemia (ALL), all of
Sheela A, Abraham, Tessa L, Holyoake
openaire   +2 more sources

Prognostic value and therapeutic targeting of XPO1 in chronic lymphocytic leukemia

Clinical and Experimental Medicine, 2023
Chronic lymphocytic leukemia (CLL) is a subtype of B-cell malignancy with high heterogeneity. XPO1 is highly expressed in many hematological malignancies, which predicts poor prognosis. In the study, we aimed to explore the prognostic role of XPO1 and the therapeutic effect of Selinexor, a selective inhibitor of nuclear export, which targets XPO1.
Huayuan Zhu, Jinhua Liang, Miao Yi
exaly   +3 more sources

Targeting XPO1 for fighting relapsed/refractory diseases: The research progress of XPO1 inhibitors

Bioorganic Chemistry
XPO1 is an influential member of the nuclear transporter protein family. The proteins and RNA transported by XPO1 are related to the occurrence and development of many diseases, including refractory tumor diseases and various viral infectious diseases. XPO1 is upregulated in many malignant tumors and is associated with poor prognosis.
Ye-Qin, Li, Zhou, Fang, Wen, Zhang, Guo-Wu, Rao, Quan, Zheng   +4 more
exaly   +3 more sources