Results 131 to 140 of about 7,047 (156)

The Evolving Landscape of Systemic Therapy for Liposarcoma. [PDF]

Cancers (Basel)
Kim HK, Sarkari A, Chow WA.
europepmc   +1 more source

Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency. [PDF]

Blood Cancer Discov
Barajas JM, Phillips AH, Wang J, Thomas ME, Contreras L, Umeda M, Hiltenbrand R, Caldwell E, Walsh MP, Song G, Ezzell L, Churion K, Westover T, Xiong E, Rolle C, Moore J, Lott J, Radko-Juettner S, Kumar A, Qi W, Xu B, Papachristou EK, D'Santos CS, Ma J, Freeman BB, Janke LJ, Kriwacki RW, Klco JM.   +27 more
europepmc   +1 more source

autoFISH: a modular toolbox for sequential single-molecule RNA FISH experiments. [PDF]

Commun Biol
Weber C, Defard T, Sturmach C, Lelek M, Laporte H, Mallick A, Gariboldi MI, Londoño-Vallejo JA, Walter T, Fouillade C, Bourg J, Mueller F.   +11 more
europepmc   +1 more source

Therapeutic Approaches Interfering with Nuclear Localization Signals: An Emerging Strategy for CNS-Related Diseases. [PDF]

Curr Neuropharmacol
Anyanwu M, Giannangeli M, Gianoncelli A, Ribaudo G.   +3 more
europepmc   +1 more source

Combination effect of Exportin 1 inhibitor (KPT-335) with doxorubicin or vincristine in canine lymphoma cell lines. [PDF]

J Vet Med Sci
Primarizky H, Kambayashi S, Baba K, Tani K, Okuda M.   +4 more
europepmc   +1 more source

Dynamic Cellular Regulation of Proteasome Translocation and Phase Transition. [PDF]

Biology (Basel)
Butcher C, Li J.
europepmc   +1 more source

Protein biomarkers for response to XPO1 inhibition in haematologic malignancies

Journal of Cellular and Molecular Medicine, 2023
XPO1 (Exportin‐1) is the nuclear export protein responsible for the normal shuttling of several proteins and RNA species between the nucleocytoplasmic compartment of eukaryotic cells.
Skye Montoya, Justin Taylor, Sana Chaudhry   +2 more
exaly   +2 more sources

Pathogenic XPO1 variants cause a dominant neurodevelopmental disorder

Genetics in Medicine
Purpose: XPO1 functions in key cellular processes, including nucleo-cytoplasmic export and mitosis. The gene is deleted in a subset of patients with the 2p15p16.1 microdeletion syndrome, however no monogenic XPO1-related disorder has been described to ...
Richard H van Jaarsveld, John Pappas, Jill A Rosenfeld   +2 more
exaly   +5 more sources

XPO1 Expression Is a Poor-Prognosis Marker in Pancreatic Adenocarcinoma

Journal of Clinical Medicine, 2019
International audiencePancreatic adenocarcinoma (PAC) is one of the most aggressive human cancers and new systemic therapies are urgently needed. Exportin-1 (XPO1), which is a member of the importin-β superfamily of karyopherins, is the major exporter of
Daniel Birnbaum, François Bertucci, Emilie Mamessier   +2 more
exaly   +2 more sources