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The nuclear export protein XPO1 — from biology to targeted therapy
Nature Reviews Clinical Oncology, 2020Exportin 1 (XPO1), also known as chromosome region maintenance protein 1, plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of cargoes, including proteins and several classes of RNAs, from the nucleus to the cytoplasm.
Ramzi Mohammad +2 more
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The STK38–XPO1 axis, a new actor in physiology and cancer
Cellular and Molecular Life Sciences, 2020The Hippo signal transduction pathway is an essential regulator of organ size during developmental growth by controlling multiple cellular processes such as cell proliferation, cell death, differentiation, and stemness. Dysfunctional Hippo signaling pathway leads to dramatic tissue overgrowth.
Alexandre PJ. Martin +3 more
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Exportin(g) precision oncology beyond genomics with XPO1 inhibition
Med, 2022We urgently need to identify new druggable targets for pediatric cancers. Coutinho et al.1 identified and validated XPO1 aberrant activity in patients with Wilms tumor (WT) and malignant rhabdoid tumor (MRT) using public databases and report an early proof-of-concept bench-to-bedside translation of XPO1 inhibition in pediatric WT and MRT.
Mohamed A, Gouda, Vivek, Subbiah
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Pathogenic XPO1 variants cause a dominant neurodevelopmental disorder
Genetics in MedicineXPO1 functions in key cellular processes, including nucleo-cytoplasmic export and mitosis. The gene is deleted in a subset of patients with the 2p15p16.1 microdeletion syndrome; however, no monogenic XPO1-related disorder has been described to date.We collected clinical data of individuals with de novo XPO1 variants through online matchmaking.
Richard H Van Jaarsveld +2 more
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Preclinical evaluation of XPO1 inhibition in Wilms tumors.
Journal of Clinical Oncology, 20203580 Background: XPO1 is a nuclear export protein that selectively transports tumor and growth regulatory proteins out of the nucleus, thereby effectively inhibiting their function. We previously utilized the Virtual Inference of Protein-activity by Enriched Regulon analysis (VIPER) algorithm to discover that malignant rhabdoid tumors were dependent ...
Michael Vincent Ortiz +10 more
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AKTing on XPO1 inhibition in AML
Nature Cancer, 2022Stefanie Göllner, Carsten Müller-Tidow
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Targeting the undruggable MYC in cancer: the rationale of using XPO1 inhibitors
Molecular Biology ReportsMYC is an important transcription factor involved in physiological processes such as cell growth, proliferation and differentiation. However, aberrant MYC expression has oncogenic-driving potential and is observed in the majority of human cancers. XPO1 is a member of the exportin family of proteins which regulate protein and RNA export from the nucleus
Leonidas, Benetatos +2 more
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Protein biomarkers for response to XPO1 inhibition in haematologic malignancies
Journal of Cellular and Molecular Medicine, 2023Justin Taylor
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Investigation into the immunomodulatory activity of XPO1 inhibitors [PDF]
Nuclear export is an important process for regulating transcription and translation by spatial distribution of transcription factors, RNA and signalling components. Exportin-1 (XPO1) is a nuclear export protein that transports key tumour suppressor proteins, oncogenic mRNA and ribosomal constituents into the cytoplasm and its function is often ...
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