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Experimental and Molecular Pathology, 2020 Circular RNAs (circRNAs) act as a key role in mediating carcinogenesis. Nevertheless, the functions and mechanisms of circRNAs in osteosarcoma (OS) are still not fully understood. In the present study, we aim to investigate the functions of circ-XPO1 in OS and its potential mechanism underlying OS progression.
Yang Jiang, Lei Shen, Yongtao Li
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Targeting XPO1-Dependent Nuclear Export in Cancer
Biochemistry (Moscow), 2022Nucleocytoplasmic transport of macromolecules is tightly regulated in eukaryotic cells. XPO1 is a transport factor responsible for the nuclear export of several hundred protein and RNA substrates. Elevated levels of XPO1 and recurrent mutations have been reported in multiple cancers and linked to advanced disease stage and poor survival.
Ekaterina, Kim +2 more
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XPO1 Expression Is a Poor-Prognosis Marker in Pancreatic Adenocarcinoma [PDF]
Journal of Clinical Medicine, 2019 Pancreatic adenocarcinoma (PAC) is one of the most aggressive human cancers and new systemic therapies are urgently needed. Exportin-1 (XPO1), which is a member of the importin-β superfamily of karyopherins, is the major exporter of many tumor suppressor proteins that are involved in the progression of PAC.
Pascal Finetti +2 more
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Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer [PDF]
International Journal of Molecular Sciences, 2019 Gastric cancer remains an unmet clinical problem in urgent need of newer and effective treatments. Here we show that the nuclear export protein, Exportin 1 (XPO1, chromosome region maintenance 1 or CRM1), is a promising molecular target in gastric cancer.
Rachel E Sexton +2 more
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Exportin(g) precision oncology beyond genomics with XPO1 inhibition
Med, 2022We urgently need to identify new druggable targets for pediatric cancers. Coutinho et al.1 identified and validated XPO1 aberrant activity in patients with Wilms tumor (WT) and malignant rhabdoid tumor (MRT) using public databases and report an early proof-of-concept bench-to-bedside translation of XPO1 inhibition in pediatric WT and MRT.
Mohamed A, Gouda, Vivek, Subbiah
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The nuclear export protein XPO1 — from biology to targeted therapy
Nature Reviews Clinical Oncology, 2020Exportin 1 (XPO1), also known as chromosome region maintenance protein 1, plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of cargoes, including proteins and several classes of RNAs, from the nucleus to the cytoplasm.
Asfar S Azmi +2 more
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Redirecting traffic using the XPO1 police
Blood, 2013In this issue of Blood, Walker et al investigate the preclinical potential of KPT-330, an exportin-1 (XPO1, also known as chromosome maintenance protein 1 [CRM1]) inhibitor, against both accelerated phase (AP) and blast crisis chronic myeloid leukemia (CML-BC) and against Philadelphia chromosome-positive (Ph1) acute lymphoblastic leukemia (ALL), all of
Sheela A, Abraham, Tessa L, Holyoake
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Prognostic and therapeutic significance of XPO1 in T-cell lymphoma
Experimental Cell Research, 2022T-cell lymphoma (TCL) is a highly heterogeneous group of invasive non-Hodgkin lymphoma with adverse prognosis and limited treatment options. The relationship between TCL and Exportin-1 (XPO1), a major nuclear export receptor, has not been established yet. We here investigated the prognostic role and therapeutic implication of XPO1 in TCL.
Danian Nie +11 more
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Targeting XPO1 for fighting relapsed/refractory diseases: The research progress of XPO1 inhibitors
Bioorganic ChemistryXPO1 is an influential member of the nuclear transporter protein family. The proteins and RNA transported by XPO1 are related to the occurrence and development of many diseases, including refractory tumor diseases and various viral infectious diseases. XPO1 is upregulated in many malignant tumors and is associated with poor prognosis.
Ye-Qin, Li +4 more
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Preclinical evaluation of XPO1 inhibition in Wilms tumors.
Journal of Clinical Oncology, 20203580 Background: XPO1 is a nuclear export protein that selectively transports tumor and growth regulatory proteins out of the nucleus, thereby effectively inhibiting their function. We previously utilized the Virtual Inference of Protein-activity by Enriched Regulon analysis (VIPER) algorithm to discover that malignant rhabdoid tumors were dependent ...
Michael Vincent Ortiz +10 more
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