Results 181 to 190 of about 9,747 (200)
Some of the next articles are maybe not open access.
Developmentally regulated activity of CRM1/XPO1 during early Xenopus embryogenesis
Journal of Cell Science, 2000ABSTRACT In this work, we have investigated the role of CRM1/XPO1, a protein involved in specific export of proteins and RNA from the nucleus, in early Xenopus embryogenesis. The cloning of the Xenopus laevis CRM1, XCRM1, revealed remarkable conservation of the protein during evolution (96.7% amino acid identity between Xenopus and human)
M, Callanan +6 more
openaire +2 more sources
The STK38–XPO1 axis, a new actor in physiology and cancer
Cellular and Molecular Life Sciences, 2020The Hippo signal transduction pathway is an essential regulator of organ size during developmental growth by controlling multiple cellular processes such as cell proliferation, cell death, differentiation, and stemness. Dysfunctional Hippo signaling pathway leads to dramatic tissue overgrowth.
Alexandre PJ. Martin +3 more
openaire +2 more sources
Electrophile Determines Cellular Phenotypes among XPO1-Targeting Small Molecules
Journal of Medicinal ChemistryCovalent drug discovery has experienced a renaissance, with numerous electrophilic small molecules recently gaining FDA approval. Many structurally diverse electrophilic small molecules target exportin-1 (XPO1/CRM1) at cysteine 528, including the selective inhibitor of nuclear export (SINE) selinexor, which was FDA-approved as an anticancer agent in ...
Yi Fan Chen +8 more
openaire +2 more sources
Understanding XPO1 Target Networks Using Systems Biology and Mathematical Modeling
Current Pharmaceutical Design, 2014The nuclear transport protein Exportin 1 (XPO1), also called chromosome region maintenance 1 (CRM1), is over-expressed 2- 4 fold in cancer. XPO1 is one of seven nuclear exporter proteins, and is solely responsible for the transport of the major tumor suppressor proteins (TSPs) from the nucleus to the cytoplasm.
Irfana, Muqbil +4 more
openaire +2 more sources
AKTing on XPO1 inhibition in AML
Nature Cancer, 2022Stefanie Göllner, Carsten Müller-Tidow
openaire +2 more sources
Cancer Research, 2015
Abstract Human Exportin-1 (XPO1) is the key nuclear-cytoplasmic transport protein that exports a variety of different cargo proteins out of the cell's nucleus. Inhibition of XPO1-mediated protein export results in nuclear retention of cargo proteins including tumour suppressor proteins and is a novel therapeutic strategy for cancer ...
Jasper E. Neggers +9 more
openaire +1 more source
Abstract Human Exportin-1 (XPO1) is the key nuclear-cytoplasmic transport protein that exports a variety of different cargo proteins out of the cell's nucleus. Inhibition of XPO1-mediated protein export results in nuclear retention of cargo proteins including tumour suppressor proteins and is a novel therapeutic strategy for cancer ...
Jasper E. Neggers +9 more
openaire +1 more source
XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer
Clinical Cancer Research, 2016Abstract Purpose: Combination of radiation with radiosensitizing chemotherapeutic agents improves outcomes for locally advanced rectal cancer. Current treatment includes 5-fluorouracil–based chemoradiation prior to surgical resection; however pathologic complete response varies from 15% to 20%, prompting the need to identify new ...
Isabel, Ferreiro-Neira +9 more
openaire +2 more sources
Expression of exportin 1 (XPO1/CRM1) in pancreatic adenocarcinoma.
Journal of Clinical Oncology, 2017327 Background: Exportin 1 (XPO1/CRM1) is a nuclear export chaperone that mediates the nuclear export of several proteins that are essential to growth regulation and tumor suppression. It was found to be overexpressed in several types of human malignancies and overexpression was found to be associated with poor prognosis.
David M Saulino +3 more
openaire +1 more source
Cancer Chemotherapy and Pharmacology
The role of selinexor, a targeted inhibitor of exportin 1 (XPO1), in the treatment of cholangiocarcinoma is not yet fully understood. This study conducted comprehensive in vitro and in vivo investigations to elucidate the effects of selinexor on cholangiocarcinoma, with a focus on its mechanistic relationship with the cellular localization of ...
Deng, Xiang +11 more
openaire +2 more sources
The role of selinexor, a targeted inhibitor of exportin 1 (XPO1), in the treatment of cholangiocarcinoma is not yet fully understood. This study conducted comprehensive in vitro and in vivo investigations to elucidate the effects of selinexor on cholangiocarcinoma, with a focus on its mechanistic relationship with the cellular localization of ...
Deng, Xiang +11 more
openaire +2 more sources