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Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy
Cancer Research, 2023Abstract Despite the remarkable clinical responses achieved with immune checkpoint blockade therapy, the response rate is relatively low and only a subset of patients can benefit from the treatment.
Xue-Bin Ran +19 more
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2023
The yeast Saccharomyces cerevisiae and most eukaryotes carry two 5’→3’ exoribonuclease paralogues that are very similar. In yeast, they are called Xrn1, which shuttles between the nucleus and cytoplasm and executes major cytoplasmic mRNA decay, and Rat1, which carries a strong nuclear localization ...
Jose Perez-Ortin +8 more
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The yeast Saccharomyces cerevisiae and most eukaryotes carry two 5’→3’ exoribonuclease paralogues that are very similar. In yeast, they are called Xrn1, which shuttles between the nucleus and cytoplasm and executes major cytoplasmic mRNA decay, and Rat1, which carries a strong nuclear localization ...
Jose Perez-Ortin +8 more
openaire +1 more source
mRNA decay: x (XRN1) marks the spot.
Molecular cell, 2003Degradation of mRNA is a vital aspect of gene expression. In yeast, Dcp1p, Dcp2p, Lsm1-7p, and Xrn1p are required for mRNA decay and are localized within discrete cytoplasmic foci; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay.
Roy M, Long, Mark T, McNally
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2001
Publisher Summary The detection, purification, and partial characterization of 5′-exoribonuclease 1 (Xrn1) from Saccharomyces cerevisiae as a 160-kDa RNase was reported in 1980 and 1985. The enzyme is a processive exonuclease hydrolyzing RNA from the 5′ end with the production of 5′-mononucleofides.
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Publisher Summary The detection, purification, and partial characterization of 5′-exoribonuclease 1 (Xrn1) from Saccharomyces cerevisiae as a 160-kDa RNase was reported in 1980 and 1985. The enzyme is a processive exonuclease hydrolyzing RNA from the 5′ end with the production of 5′-mononucleofides.
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Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer
2023Abstract Viral mimicry describes the immune response induced by endogenous stimuli such as dsRNA formed by endogenous retroelements. Activation of viral mimicry has the potential to kill cancer cells or augment anti-tumor immune response.
Amir Hosseini +6 more
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Neuroscience Letters, 2018
mRNA turnover controls gene expression under various conditions in aging and neurodegenerative diseases. Polyglutamine (polyQ) diseases and intranuclear inclusion body disease (INIBD) are neurodegenerative diseases characterized by the formation of nuclear inclusions.
Fumiaki, Mori +8 more
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mRNA turnover controls gene expression under various conditions in aging and neurodegenerative diseases. Polyglutamine (polyQ) diseases and intranuclear inclusion body disease (INIBD) are neurodegenerative diseases characterized by the formation of nuclear inclusions.
Fumiaki, Mori +8 more
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Transcriptomic discovery of Xrn1-interacting genes and pathways.
Xrn1 lies at the crux of a critical set of signaling pathways that regulate penetrance in IBD and control emergence and pathogenesis of inflammatory bowel disease like Crohn's Disease in humans. We used HEK293T cells genetically engineered to lack expression of Xrn1 (XRN1 -/- or XRN1 KO cells) coupled with next-generation sequencing methods (RNA ...openaire +1 more source
Xrn1-resistant RNA structures are well-conserved within the genus flavivirus
RNA Biology, 2021Ivar W Dilweg +2 more
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