Results 171 to 180 of about 7,632 (199)
The dynamic interactions between virus infections and nonsense-mediated decay. [PDF]
Hum Mol Genetvan der Klugt T, van Gent M.
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Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease. [PDF]
Sci AdvJang Y +17 more
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The 5′ → 3′ exoribonuclease XRN1/Pacman and its functions in cellular processes and development [PDF]
Wiley Interdisciplinary Reviews RNA, 2012 XRN1 is a 5' → 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Christopher Iain Jones
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Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy
Cancer Research, 2023Abstract Despite the remarkable clinical responses achieved with immune checkpoint blockade therapy, the response rate is relatively low and only a subset of patients can benefit from the treatment.
Xue-Bin Ran +19 more
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Structure of the 80S ribosome–Xrn1 nuclease complex
Nature Structural and Molecular Biology, 2019Messenger RNA (mRNA) homeostasis represents an essential part of gene expression, in which the generation of mRNA by RNA polymerase is counter-balanced by its degradation by nucleases. The conserved 5'-to-3' exoribonuclease Xrn1 has a crucial role in eukaryotic mRNA homeostasis by degrading decapped or cleaved mRNAs post-translationally and, more ...
Petr Tesina +2 more
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Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay [PDF]
Molecular Cell, 2011 Messenger RNA decay plays a central role in the regulation and surveillance of eukaryotic gene expression. The conserved multidomain exoribonuclease Xrn1 targets cytoplasmic RNA substrates marked by a 5' monophosphate for processive 5'-to-3' degradation by an unknown mechanism. Here, we report the crystal structure of an Xrn1-substrate complex.
Martin Jinek, Jennifer A Doudna
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Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1 [PDF]
Nature Structural and Molecular Biology, 2011 The 5'→3' exoribonucleases (XRNs) have important functions in transcription, RNA metabolism and RNA interference. The structure of Rat1 (also known as Xrn2) showed that the two highly conserved regions of XRNs form a single, large domain that defines the active site of the enzyme.
Jeong Ho Chang, Liang Tong
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mRNA decay: x (XRN1) marks the spot.
Molecular cell, 2003Degradation of mRNA is a vital aspect of gene expression. In yeast, Dcp1p, Dcp2p, Lsm1-7p, and Xrn1p are required for mRNA decay and are localized within discrete cytoplasmic foci; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay.
Roy M, Long, Mark T, McNally
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Abstract B073: Characterization of selective, allosteric inhibitors of human XRN1
Molecular Cancer Therapeutics, 2023Abstract Background: 5′→3′ exoribonuclease 1 (XRN1) plays an important role in innate immunity by preventing double stranded RNA (dsRNA) accumulation. In addition, XRN1 has emerged as a potential target for drug discovery efforts as tumors with high interferon signaling are sensitive to XRN1 loss using genetic tools.
Gordon J Lockbaum +10 more
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