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2023
The yeast Saccharomyces cerevisiae and most eukaryotes carry two 5’→3’ exoribonuclease paralogues that are very similar. In yeast, they are called Xrn1, which shuttles between the nucleus and cytoplasm and executes major cytoplasmic mRNA decay, and Rat1, which carries a strong nuclear localization sequence (NLS) and localizes in the nucleus. Xrn1 is 40%
Jose Perez-Ortin +8 more
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The yeast Saccharomyces cerevisiae and most eukaryotes carry two 5’→3’ exoribonuclease paralogues that are very similar. In yeast, they are called Xrn1, which shuttles between the nucleus and cytoplasm and executes major cytoplasmic mRNA decay, and Rat1, which carries a strong nuclear localization sequence (NLS) and localizes in the nucleus. Xrn1 is 40%
Jose Perez-Ortin +8 more
openaire +1 more source
2001
Publisher Summary The detection, purification, and partial characterization of 5′-exoribonuclease 1 (Xrn1) from Saccharomyces cerevisiae as a 160-kDa RNase was reported in 1980 and 1985. The enzyme is a processive exonuclease hydrolyzing RNA from the 5′ end with the production of 5′-mononucleofides.
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Publisher Summary The detection, purification, and partial characterization of 5′-exoribonuclease 1 (Xrn1) from Saccharomyces cerevisiae as a 160-kDa RNase was reported in 1980 and 1985. The enzyme is a processive exonuclease hydrolyzing RNA from the 5′ end with the production of 5′-mononucleofides.
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XRN1: A Major 5′ to 3′ Exoribonuclease in Eukaryotic Cells
2012The degradation of RNA is a critical aspect of gene regulation. Correspondingly, ribonucleases exist within the cell to degrade RNA in specific cellular contexts. An important and conserved ribonuclease is called XRN1. This enzyme, an exoribonuclease, degrades RNA in a processive 5' to 3' direction.
Sarah, Geisler, Jeff, Coller
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Neuroscience Letters, 2018
mRNA turnover controls gene expression under various conditions in aging and neurodegenerative diseases. Polyglutamine (polyQ) diseases and intranuclear inclusion body disease (INIBD) are neurodegenerative diseases characterized by the formation of nuclear inclusions.
Fumiaki, Mori +8 more
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mRNA turnover controls gene expression under various conditions in aging and neurodegenerative diseases. Polyglutamine (polyQ) diseases and intranuclear inclusion body disease (INIBD) are neurodegenerative diseases characterized by the formation of nuclear inclusions.
Fumiaki, Mori +8 more
openaire +2 more sources
Detection and quantification of RNA decay intermediates using XRN1-resistant reporter transcripts
Nature Protocols, 2019RNA degradation ensures appropriate levels of mRNA transcripts within cells and eliminates aberrant RNAs. Detailed studies of RNA degradation dynamics have been heretofore infeasible because of the inherent instability of degradation intermediates due to the high processivity of the enzymes involved. To visualize decay intermediates and to characterize
Franka Voigt +6 more
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Xrn1 controls Parp9/14 activation.
Activation of the enzymes Parp9 and Parp14 is a common transcriptional feature of pathways important for IBD, identified by gene or casual variant of interest, including NOD2, TRIM22, and XIAP. Aberrant Parp9/14 pathway signaling is found in NOD2 mutant cells and in patient tissues of humans with IBD (Crohn's Disease).openaire +1 more source
Xrn1-resistant RNA structures are well-conserved within the genus flavivirus
RNA Biology, 2021Ivar W Dilweg, Tim J Dalebout
exaly