Results 181 to 190 of about 110,075 (237)

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

The FEBS Journal, EarlyView.
Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester, Owen Leitzel, Samantha Golf, Chelsea M. Phillips, Michael J. Zeitz, Rahul Pandit, Elizabeth Wash, Jenna V. Donohue, Elizabeth A. Istre, James W. Smyth, Samy Lamouille, Stefanie Robel   +11 more
wiley   +1 more source

Recent advances in the identification and quantification of xylazine and medetomidine in biological specimens. [PDF]

Bioanalysis
Crews BO.
europepmc   +1 more source

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

International Endodontic Journal, EarlyView.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang, Jiawei Liu, Xintao Yang, Mohamad Koohi‐Moghadam, Shuting Gao, Yuanyuan Han, Dineshi Sewvandi Thalakiriyawa, James Kit Hon Tsoi, Yanqi Yang, Waruna Lakmal Dissanayaka   +9 more
wiley   +1 more source

Prevalence of Illicit Drug Detection in 5 US Cities Among Out-of-Treatment People Who Inject Drugs.

JAMA Netw Open
El-Bassel N, Shoptaw S, Skalland T, Hanscom B, Clarke W, Marzinke MA, Fogel JM, Richardson P, Choudhury RP, Denis C, Goodman-Meza D, Kuo I, Lake JE, Morrison EAB, Richards AM, Harris-Wisecarver J, Cummings M, Chandler R, Andrew P, HPTN 094 Study Team.   +19 more
europepmc   +1 more source

Characterizing patterns of opioid and stimulant use by route and associations with non-fatal overdose and xylazine use in people who have injected drugs from Baltimore, MD, 2023-2024. [PDF]

Drug Alcohol Depend Rep
Rudolph JE, Martinez-Ocasio LM, Feder KA, Tomko C, Cepeda JA, Kirk GD, Mehta SH, German D, Genberg BL.   +8 more
europepmc   +1 more source

High‐Fat Diet Reprograms the Periapical Immune Landscape in a Mouse Model of Apical Periodontitis: A Spatial Transcriptomics Study

International Endodontic Journal, EarlyView.
ABSTRACT Introduction Apical periodontitis (AP) is an inflammatory disease of the periapical tissues driven by host responses to endodontic infection, and systemic metabolic disturbances, such as high‐fat diet (HFD)–induced dysmetabolism, may exacerbate tissue destruction. This study aimed to determine how chronic HFD exposure alters periapical myeloid
Maryam Ghaffari, Aiman Ali, Clement Hartadi, Annie Shrestha   +3 more
wiley   +1 more source

Self-Reported History of Precipitated Withdrawal: A Cross-Sectional Study of People Who Use Unregulated Opioids. [PDF]

J Addict Med
Figgatt MC, Serafinski RL, Ujeneza M, Turbidez J, McKenzie M, Park JN, Grossman ER, Rich J, Green TC.   +8 more
europepmc   +1 more source

Early Presentation of Acute Digital Ischemia After Intra-Arterial Injection Drug Use. [PDF]

J Hand Surg Glob Online
Echeverria N, Kurucan E, Gubara K, Solarz M.   +3 more
europepmc   +1 more source

Early axonal injury in fentanyl intoxication. [PDF]

Acta Neuropathol Commun
Gomez-Isaza L, Pletnikova O, Luongo M, Morris M, Ning X, Yun K, Phipps R, Blanchard TG, Dean S, Li L, Troncoso JC.   +10 more
europepmc   +1 more source