Results 191 to 200 of about 119,267 (282)

Does Kappa Agonism Improve Reversal of 'Tranq-Dope' Overdose? Evidence from a Rodent Model. [PDF]

Pharmaceuticals (Basel)
Voronkov M, Cernea M, Stefanut C, Nikonov G, Milevich G, Abernethy J.   +5 more
europepmc   +1 more source

CD68 and F4/80 Markers Demonstrate Inflammatory Synergism Between Apical Periodontitis and Liver Fibrosis in Wistar Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate CD68 and F4/80 glycoproteins in the worsening of apical periodontitis (AP) and liver fibrosis (LF) in Wistar rats. Methodology Thirty‐two Wistar rats were distributed in the following groups (n = 8): C—control; AP—apical periodontitis; LF—liver fibrosis; APLF—AP and LF.
L. V. Barroti, C. Cantiga‐Silva, M. P. Justo, P. H. C. Oliveira, F. D. Faria, J. Goto, E. Ervolino, G. Sivieri‐Araújo, T. N. Pinheiro, L. T. A. Cintra   +9 more
wiley   +1 more source

The evolving epidemiology of opioid use disorder: polysubstance use, drug supply transformation, and policy implications. [PDF]

Front Public Health
Mandapati NK, Tovar DC, Bindlish R, Hernandez YL, Alves MJ, Baum MK, Aggarwal S.   +6 more
europepmc   +1 more source

Chronic Excessive Exercise Aggravates Apical Periodontitis in Mice

International Endodontic Journal, EarlyView.
ABSTRACT Aim To investigate the effects of overtraining on the development of apical periodontitis (AP) in mice. Methodology Sixty 6‐week‐old male C57BL/6 mice were allocated to six groups: sedentary without AP (SED); sedentary with AP (SED AP); aerobic training without AP (AERO); aerobic training with AP (AERO AP); overtraining without AP (OVER); and ...
Andréia Bosco Boaventura, Rosmeli Daysi Coasaca‐Rivera, Bárbara Roma Mendes, Sandra Lia do Amaral, Adelino Sanchez Ramos da Silva, Paulo Sergio Cerri, Gisele Faria   +6 more
wiley   +1 more source

Commentary on German et al.: Qualitative inquiry reduces lags in scientific discovery-to-practice by recognizing the living expertise of people who use drugs. [PDF]

Addiction
Reed MK.
europepmc   +1 more source

STAG Priming Preserves Paneth Cells and Limits Parasite‐Triggered Ileitis

Immunology &Cell Biology, EarlyView.
Preservation of Paneth cells is associated with resistance to ileitis caused by Toxoplasma gondii. ABSTRACT Toxoplasma gondii triggered ileitis is a commonly used model for diseases affecting the small intestine, such as Crohn's Disease. Inflammation is primarily dependent on Th1‐mediated killing of Paneth cells, which consequently promotes intestinal ...
Ester Cristina Borges Araujo, Luciana Alves Sousa, Marisol Pallete Briceno, Loyane Bertagnolli Coutinho, Alexsandra Alves Bezerra Martins, Anne Fenton, Sumathi Sankaran‐Walters, Paulo Czarnewski, Neide Maria Silva   +8 more
wiley   +1 more source

Immunomodulatory Peptide LW‐9 Enhances Doxorubicin Efficacy by Downregulating PD‐L1 and Promoting Intratumoral T‐Cell Responses in Murine Breast Cancer

Immunology, EarlyView.
LW‐9, a peptide derived from Phoneutria nigriventer venom, enhances antitumor immunity in a murine breast cancer model by remodelling the tumour microenvironment. Treatment reduces PD‐L1 expression while increasing CD3+ and GITR+ T‐cell infiltration, resulting in delayed tumour progression, particularly when combined with doxorubicin.
Ingrid Mayara Cavalcante Trevisan, Cibele Pereira Mariano, Sabrina Carvalho Brunelli, Gabriel da Silva Cordeiro, Jessika Takaki, Valquiria Aparecida Matheus, Liana Verinaud, Catarina Rapôso   +7 more
wiley   +1 more source

Sedative choice alters <i>Klebsiella pneumoniae</i> lung pathogenesis and dissemination. [PDF]

Infect Immun
Mains DR, Rotman ER, Aman DK, Ludvik DA, Desikan A, Kocher AA, Tran ANH, Mandel MJ, Freitag NE.   +8 more
europepmc   +1 more source

Wiskott–Aldrich Syndrome Protein Is Required for Glucocorticoid‐Dependent Eosinopoiesis and Eosinophil‐Rich Inflammation in Murine Models

Immunology, EarlyView.
WASP links GC‐dependent bone marrow eosinopoiesis to eosinophil‐rich allergic lung inflammation. GC‐responsive WASP+ stromal niche drives eosinopoiesis, generating eosinophilic lung inflammation and airway hyperresponsiveness. In WASP‐deficient allergic asthma, GC production and airway hyperresponsiveness are preserved, but GC‐driven bone marrow ...
Bruno Marques Vieira, Lucas Everton Simões, Pedro Xavier‐Elsas, Maria Ignez Capella Gaspar‐Elsas   +3 more
wiley   +1 more source

Evidence that xylazine disrupts skin homeostasis by acting on epithelial cells through the kappa opioid receptor. [PDF]

Dis Model Mech
Robertson TF, Horn A, Smith FM, Huttenlocher A.   +3 more
europepmc   +1 more source