medRxiv, 2021 Background: Recent sharp exacerbations of the US overdose crisis have been linked to systemic polysubstance use and potent synthetic compounds in numerous drug classes. Xylazine is a veterinary tranquilizer, long noted in the opioid supply of Puerto Rico,
Joseph R. Friedman +6 more
semanticscholar +1 more source
Reducing the harms of xylazine: clinical approaches, research deficits, and public health context
Harm Reduction Journal, 2023 Objectives Xylazine has emerged as a consistent part of the unregulated drug supply in recent months. We discuss major domains of xylazine’s harm, current knowledge deficits, clinical and harm reduction strategies for minimizing harm, and xylazine’s ...
Claire M. Zagorski +9 more
semanticscholar +1 more source
Xylazine in the Opioid Epidemic: A Systematic Review of Case Reports and Clinical Implications
Cureus, 2023 Introduction and objectives: The opioid overdose epidemic is exacerbated by the emergence of Xylazine as an illicit drug adulterant. Xylazine, a veterinary sedative, can potentiate opioid effects while also causing toxic and potentially fatal side ...
S. Ayub +7 more
semanticscholar +1 more source
Comparison of two ketamine/xylazine anesthesic protocols in pigs (Sus crofa domestica) [PDF]
, 2018 The pig (Sus scrofa domestica) is an animal used as an experimental model in surgical procedures. This makes the use of anaesthesia necessary. The present study constitutes a comparison between two different ketamine/xylazine concentration protocols. One
Gargiulo, Pascual Angel +3 more
core +1 more source
Guaiphenesin-ketamine-xylazine infusion to maintain anesthesia in mules undergoing field castration. [PDF]
, 2017 Background: In order to determine whether a combination of guaiphenesin, ketamine and xylazine can induce safe and satisfactory anaesthesia in mules undergoing field castration, eight healthy adult intact male mules were employed.
Augusto, Carluccio +5 more
core +1 more source
Neurotoxicity of xylazine in chicks [PDF]
Iraqi Journal of Veterinary Sciences, 2023 Despite the widespread use of xylazine in veterinary medicine, studies on its neurotoxicity are limited. So, our current study aims to reveal its neurotoxicity in chicks by determining the (LD50) of xylazine in Dixon's procedure.
Muna H. ALzubaidy +2 more
doaj +1 more source
Sedative and antinociceptive effects of different combinations of detomidine and methadone in standing horses [PDF]
, 2017 Objective To evaluate intravenous (IV) detomidine with methadone in horses to identify a combination which provides sedation and antinociception without adverse effects. Study design Randomized, placebo-controlled, blinded, crossover.
Crosignani, N +6 more
core +2 more sources
Evaluating the sedative and analgesic effects of xylazine and it’s interaction with chloropromazine in chicks [PDF]
Iraqi Journal of Veterinary Sciences, 2019 The aim of this study was to evaluate the sedative effect of xylazine alone or as a combination with chloropromazine, and to check the possibility to induce analgesia by the use of sedative (sub analgesic) doses of this combination in chicks.
M. Hasan
doaj +1 more source
Interpreting Neuroendocrine Hormones, Corticosterone, and Blood Glucose to Assess the Wellbeing of Anesthetized Rats during Euthanasia [PDF]
, 2018 Current recommendations for assessing animal wellbeing during euthanasia suggest that measuring neuroendocrine hormones-such as ACTH, noradrenaline, and adrenaline-is preferable to measuring corticosterone and blood glucose because of the sensitivity of ...
Hickman, Debra L.
core +1 more source
The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]
, 2018 Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos +15 more
core +1 more source