Results 51 to 60 of about 157,061 (320)

Behavioral and cardiopulmonary effects of dexmedetomidine alone and in combination with butorphanol, methadone, morphine or tramadol in conscious sheep [PDF]

, 2016
Objective: To compare cardiopulmonary and sedative effects following administration of dexmedetomidine alone or with butorphanol, methadone, morphine or tramadol in healthy sheep. Study design: Randomized crossover study. Animals: Six Santa Inês
Auckburally, Adam, Borges, Luisa P.B., Carvalho, Leonardo L., Cerejo, Sofia A., Mattos-Junior, Ewaldo, Nishimura, Lilian T.   +5 more
core   +1 more source

National Institute on Drug Abuse Clinical Trials Network Meeting Report: Managing Patients Exposed to Xylazine-Adulterated Opioids in Emergency, Hospital and Addiction Care Settings.

Annals of Emergency Medicine
Used as a veterinary sedative and not approved for human use, xylazine has been increasingly linked with opioid overdose deaths in the United States.
Jeanmarie Perrone, R. Haroz, Joseph D’Orazio, Giacomo Gianotti, Jennifer Love, M. Salzman, M. Lowenstein, Ashish P. Thakrar, Stephanie Klipp, Lisa Rae, Megan K. Reed, Edward Sisco, R. Wightman, Lewis S. Nelson   +13 more
semanticscholar   +1 more source

From In‐Silico Optimized Microfabrication to Experimental Validation: Engineering a Tridimensional Epi‐Intraneural Interface

Advanced Functional Materials, EarlyView.
An epi‐intraneural interface is developed through in silico optimization and a novel tridimensional microfabrication pipeline. The device integrates penetrating and epineural contacts on a flexible substrate. Mechanical, electrochemical, and in vivo testing in rat and pig reveal robust implantation, low‐threshold activation, and site‐dependent ...
Federico Ciotti, Andrea Cimolato, Noemi Gozzi, Pietro Palopoli, Luca Brugnoli, Natalija Katic Secerovic, Rebecca Gallivan, Alexander Shokurov, Carlo Menon, Johannes Weichart, Ignacio Delgado‐Martinez, Weiguo Song, Stavros Zanos, Xavier Navarro, Stanisa Raspopovic   +14 more
wiley   +1 more source

Knowledge, Preference, and Adverse Effects of Xylazine Among Adults in Substance Use Treatment

JAMA Network Open
This cross-sectional study evaluates aspects of xylazine adulteration of opioids among individuals entering substance use disorder treatment.
Martin Hochheimer, J. Strickland, Jill A. Rabinowitz, Jennifer D Ellis, Kelly E Dunn, Andrew S. Huhn   +5 more
semanticscholar   +1 more source

An Ionic Gelation Powder for Ultrafast Hemostasis and Accelerated Wound Healing

Advanced Functional Materials, EarlyView.
An ultrafast ionic gelation‐activated hemostatic powder (AGCL) forms a hydrogel within ≈1 s upon contact with blood‐derived calcium ions. The AGCL powder enables rapid hemorrhage control, strong tissue adhesion, and enhanced healing. The powder's pre‐crosslinked polymer network ensures high blood uptake and stability, offering effective treatment for ...
Youngju Son, Kyusoon Pak, Taehoon Lee, Monica Celine Prayogo, Jinyoung Choi, Sukkyung Kang, Minjoo Kang, Byungkook Oh, Sang Yu Sun, Sanha Kim, Sung Gap Im, Sangyong Jon, Steve Park   +12 more
wiley   +1 more source

The role of external broadcasting in a closed political system [PDF]

, 2011
This article investigates the role and impact of external broadcasting (radio and television) on a closed political system, through the example of the two post-war German states: the West German Federal Republic of Germany (FRG) and the East German ...
Andreas Scheu, Browne DR, Castells M., Corbin J., DeFleur ML, Der Spiegel, Hafez K., Hahn O., Hesse KR, Hopkins M., Hyman HH, Infratest, Infratest, Infratest, Infratest, Jansen M., Lindlof T., McQuail D., Merritt AJ, Merritt AJ, Meyen M., Michael Meyen, Parta RE, Perse EM   +23 more
core   +2 more sources

Broad evidence of xylazine in the UK illicit drug market beyond heroin supplies: Triangulating from toxicology, drug-testing and law enforcement.

Addiction
BACKGROUND AND AIMS Xylazine is a non-opioid sedative which has spread rapidly throughout the US illicit drug supply. This study aimed to describe the spread of xylazine throughout the UK illicit drug supply.
C. Copeland, Kathleen Rice, Kirsten L. Rock, Simon Hudson, Peter Streete, Alexander J Lawson, Lewis Couchman, Adam Holland, Stephen Morley   +8 more
semanticscholar   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Involvement of ATP-Sensitive K+ Channels in the Peripheral Antinociceptive Effect Induced by the α2-Adrenoceptor Agonist Xylazine

Journal of Pharmacological Sciences, 2009
Xylazine is an α2-adrenergic agonist extensively used in veterinary medicine and animal experimentation for producing antinociception, sedation, and muscle relaxation.
Thiago Roberto Lima Romero, Igor Dimitri Gama Duarte   +1 more
doaj   +1 more source

Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. [PDF]

, 2017
BackgroundGastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation.ObjectiveTo determine whether pre-anesthetic orally administered omeprazole ...
Belafsky, PC, Della Maggiore, A, Fulton, A, Garcia, RS, Marks, SL, Osborn, JM, Pierce, T, Pypendop, BH, Walker, VJ   +8 more
core   +3 more sources