Results 221 to 230 of about 58,968 (247)
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Science Signaling, 2020
CDK7 promotes cell proliferation and tissue growth by protecting the transcriptional coactivator Yap from degradation.
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CDK7 promotes cell proliferation and tissue growth by protecting the transcriptional coactivator Yap from degradation.
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Science Signaling, 2016
YAP helps to define where cells undergoing mitosis separate.
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YAP helps to define where cells undergoing mitosis separate.
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Nature Reviews Cancer, 2018
Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
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Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
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YAP condensates are highly organized hubs for YAP/TEAD transcription
2022SummaryYAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecular condensates in response to hyperosmotic stress, concentrating transcription-related factors to activate ...
Siyuan Hao +7 more
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Nature Reviews Cancer, 2010
A complex interdependent regulatory network exists between YAP, ASPP1 and LATS in the control of apoptosis.
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A complex interdependent regulatory network exists between YAP, ASPP1 and LATS in the control of apoptosis.
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Science Signaling, 2014
Statins limit breast cancer cell migration by inhibiting the transcriptional coactivator YAP.
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Statins limit breast cancer cell migration by inhibiting the transcriptional coactivator YAP.
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Role of YAP/TAZ in mechanotransduction
Nature, 2011Cells perceive their microenvironment not only through soluble signals but also through physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined adhesiveness. By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple aspects of cell behaviour, including growth ...
DUPONT, SIRIO +11 more
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Science Signaling, 2011
Stress fibers promote nuclear accumulation of Yap, thus promoting proliferation.
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Stress fibers promote nuclear accumulation of Yap, thus promoting proliferation.
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YAP and TAZ Drive Melanoma through Overlapping and YAP Specific Pathways
2020Melanoma is an aggressive tumor with a high degree of metastasis and limited therapeutic options. Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) are transcriptional coregulators implicated in driving tumor progression and metastasis in a wide variety of cancers, including melanoma.
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A YAP-derived peptide blocks YAP-TEAD signaling and suppresses cell proliferation
Cellular SignallingYes-associated protein (YAP), a pivotal transcriptional co-activator in cell growth regulation, exerts its function through interactions with transcriptional factors like TEAD. Ectopic activation of YAP causes excessive cell proliferation, leading to multiple human diseases, including cancers.
Qiuyun, Yuan +4 more
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