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Nature Chemical Biology, 2021
YAP is a major downstream effector of the Hippo intracellular signaling pathway, with key roles in organ development, regeneration, and cancer biology. A small molecule that targets Annexin (ANX) acts through YAP to promote rapid epidermal tissue expansion.
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YAP is a major downstream effector of the Hippo intracellular signaling pathway, with key roles in organ development, regeneration, and cancer biology. A small molecule that targets Annexin (ANX) acts through YAP to promote rapid epidermal tissue expansion.
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Science Signaling, 2011
The transcriptional regulators YAP and TAZ relay mechanical cues from the environment to the nucleus.
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The transcriptional regulators YAP and TAZ relay mechanical cues from the environment to the nucleus.
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Science Signaling, 2013
The methyltransferase Set7 promotes cytoplasmic retention of the transcriptional coactivator Yap.
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The methyltransferase Set7 promotes cytoplasmic retention of the transcriptional coactivator Yap.
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Science Signaling, 2020
CDK7 promotes cell proliferation and tissue growth by protecting the transcriptional coactivator Yap from degradation.
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CDK7 promotes cell proliferation and tissue growth by protecting the transcriptional coactivator Yap from degradation.
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Science Signaling, 2016
YAP helps to define where cells undergoing mitosis separate.
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YAP helps to define where cells undergoing mitosis separate.
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Nature Reviews Cancer, 2018
Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
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Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
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YAP condensates are highly organized hubs for YAP/TEAD transcription
2022SummaryYAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecular condensates in response to hyperosmotic stress, concentrating transcription-related factors to activate ...
Siyuan Hao +7 more
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Nature Reviews Cancer, 2010
A complex interdependent regulatory network exists between YAP, ASPP1 and LATS in the control of apoptosis.
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A complex interdependent regulatory network exists between YAP, ASPP1 and LATS in the control of apoptosis.
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