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Nature Chemical Biology, 2021
YAP is a major downstream effector of the Hippo intracellular signaling pathway, with key roles in organ development, regeneration, and cancer biology. A small molecule that targets Annexin (ANX) acts through YAP to promote rapid epidermal tissue expansion.
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YAP is a major downstream effector of the Hippo intracellular signaling pathway, with key roles in organ development, regeneration, and cancer biology. A small molecule that targets Annexin (ANX) acts through YAP to promote rapid epidermal tissue expansion.
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Roles of YAP/TAZ in ferroptosis
Trends in Cell Biology, 2022Ferroptosis is a unique iron-dependent form of regulated cell death. Recently, researchers found that ferroptosis was sensitive to cell density, regulated by Hippo signaling. This article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in ferroptosis and the ...
Suchitra Magesh, Danfeng Cai
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Role of YAP/TAZ in mechanotransduction
Nature, 2011Cells perceive their microenvironment not only through soluble signals but also through physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined adhesiveness. By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple aspects of cell behaviour, including growth ...
DUPONT, SIRIO +11 more
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Science Signaling, 2016
YAP helps to define where cells undergoing mitosis separate.
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YAP helps to define where cells undergoing mitosis separate.
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YAP and TAZ Are Not Identical Twins
Trends in Biochemical Sciences, 2021Yes-associated protein (YAP) and TAZ (WW domain containing transcription regulator 1, or WWTR1) are paralog transcriptional regulators, able to integrate mechanical, metabolic, and signaling inputs to regulate cell growth and differentiation during development and neoplastic progression.
Francesca, Reggiani +3 more
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Seismic observations at the Yap Islands and the northern Yap Trench
Tectonophysics, 1997Abstract We conducted two seismic surveys in the Yap region to investigate tectonic activity in this area. One was conducted in the northern Yap Trench for ten days using ocean bottom seismometers, the other was conducted on the Yap Islands for eight months using a small array.
Toshinori Sato +5 more
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Nature Reviews Cancer, 2018
Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
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Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
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Nature Reviews Cancer, 2010
A complex interdependent regulatory network exists between YAP, ASPP1 and LATS in the control of apoptosis.
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A complex interdependent regulatory network exists between YAP, ASPP1 and LATS in the control of apoptosis.
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Science Signaling, 2011
Stress fibers promote nuclear accumulation of Yap, thus promoting proliferation.
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Stress fibers promote nuclear accumulation of Yap, thus promoting proliferation.
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