Results 81 to 90 of about 7,882 (190)

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells [PDF]

, 2014
BACKGROUND: Sox2, a transcription factor and an embryonic stem cell marker, has been implicated in the pathogenesis of breast cancer (BC). YB-1 is another transcription factor that has been shown to promote stemness in BC cells. METHODS: Western blotting,
Bassam S Abdulkarim, Fang Wu, Karen Jung, Peng Wang, Raymond Lai, Xiaoxia Ye   +5 more
core   +2 more sources

SiCmiR Atlas: Single‐Cell miRNA Landscape Reveals Hub‐miRNA and Network Signatures in Human Cancers

Advanced Science, Volume 13, Issue 16, 18 March 2026.
SiCmiR predicts mature miRNA activity at single‐cell resolution using only 977 landmark genes, enabling scalable reconstruction of miRNA landscapes across diverse tissues and disease contexts. The SiCmiR Atlas integrates 9.36 million cells with analytical tools for hub‐miRNA discovery, biomarker prioritization, and regulatory network interrogation ...
Xiao‐Xuan Cai, Jing‐Shan Liao, Jia‐Jun Ma, Yu‐Xuan Pang, Yi‐Gang Chen, Yang‐Chi‐Dung Lin, Yi‐Dan Chen, Xin Cao, Yi‐Cheng Zhang, Tao‐Sheng Xu, Tzong‐Yi Lee, Hsi‐Yuan Huang, Hsien‐Da Huang   +12 more
wiley   +1 more source

Mitochondrial YBX1 promotes cancer cell metastasis by inhibiting pyruvate uptake

Life Metabolism, 2023
Abstract Pyruvate is an essential fuel for maintaining the tricarboxylic acid (TCA) cycle in the mitochondria. However, the precise mole­cular mechanism of pyruvate uptake by mitochondrial pyruvate carrier (MPC) is largely unknown.
Huan Chen, Ting Ling, Di Chen, Wenjuan Liu, Huan Qi, Tian Xia, Xiaolong Liu, Wen Wang, Xin Guo, Wuxiyar Otkur, Fangjun Wang, Zhaochao Xu, Jean-Claude Martinou, Hai-long Piao   +13 more
openaire   +1 more source

Validation-based insertional mutagenesis (VBIM) technology identifies adenomatous polypossis coli (APC) like protein (ALP) as a novel negative regulator of NF-κB [PDF]

, 2015
Colorectal cancer (CRC) is the third leading cause of cancer related deaths in the United States. The nuclear factor κB (NF-κB) is an important family of transcription factors whose aberrant activation has been found in many types of cancer, including
Mundade, Rasika S.
core   +1 more source

YBX1 promotes tumor growth by elevating glycolysis in human bladder cancer

Oncotarget, 2017
Aerobic glycolysis, also known as Warburg effect, is a key hallmark of cancers. The Y-box-binding protein 1 (YBX1) is a well-known oncoprotein implicated in multiple malignant phenotypes of cancers. Meanwhile, little is known about the oncogenic functions and mechanisms of YBX1 in bladder cancer.
Xu, Liuyu, Li, Hongyun, Wu, Longchao, Huang, Shiming   +3 more
openaire   +3 more sources

The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level [PDF]

Nature Communications, 2018
AbstractThe integrity of stratified epithelia depends on the ability of progenitor cells to maintain a balance between proliferation and differentiation. While much is known about the transcriptional pathways underlying progenitor cells’ behavior in the epidermis, the role of posttranscriptional regulation by mRNA binding proteins—a rate-limiting step ...
Kwon, Eunjeong, Todorova, Kristina, Wang, Jun, Neel, Victor, Lee, Sam, Mandinova, Anna, Horos, Rastislav, Lee, Kevin K., Negri, Gian Luca, Sorensen, Poul H., Hentze, Matthias W.   +10 more
openaire   +4 more sources

An essential role for maternal control of Nodal signaling

eLife, 2013
Growth factor signaling is essential for pattern formation, growth, differentiation, and maintenance of stem cell pluripotency. Nodal-related signaling factors are required for axis formation and germ layer specification from sea urchins to mammals ...
Pooja Kumari, Patrick C Gilligan, Shimin Lim, Long Duc Tran, Sylke Winkler, Robin Philp, Karuna Sampath   +6 more
doaj   +1 more source

PLK1 inhibition promotes apoptosis and DNA damage in glioma stem cells by regulating the nuclear translocation of YBX1

Cell Death Discovery, 2023
Glioma stem cells (GSCs) are the important cause of tumorigenesis, recurrence, and chemo(radio)resistance in glioma. Targeting GSCs helps improve the outcomes of glioma treatment.
Xuetao Li, Guangliang Chen, Bin Liu, Zhennan Tao, Yue Wu, Kai Zhang, Zibin Feng, Yulun Huang, Hao Wang   +8 more
doaj   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, Volume 13, Issue 14, 9 March 2026.
CGRP interacts with HMEC‐1 by binding to surface receptors, influencing the downstream FAK/AKT/VEGF signaling pathway, and promoting the secretion of ANGPTL4 from vascular endothelial cells into the bone microenvironment. This, in turn, regulates the differentiation of BMSCs into osteoblasts, thus promoting bone formation. ABSTRACT Bone angiogenesis is
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source