Results 61 to 70 of about 257,444 (202)
Applications of Yeast Surface Display for Protein Engineering [PDF]
, 2015 The method of displaying recombinant proteins on the surface of Saccharomyces cerevisiae via genetic fusion to an abundant cell wall protein, a technology known as yeast surface display, or simply, yeast display, has become a valuable protein engineering tool for a broad spectrum of biotechnology and biomedical applications.
Gerald M, Cherf, Jennifer R, Cochran
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, 2008 WormBase (www.wormbase.org) is the major publicly available database of information about Caenorhabditis elegans, an important system for basic biological and biomedical research. Derived from the initial ACeDB database of C. elegans genetic and sequence
A. Petcherski +51 more
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Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display [PDF]
Protein Engineering, Design and Selection, 2011 Reliable and robust systems for engineering functional major histocompatibility complex class II (MHCII) proteins have proved elusive. Availability of such systems would enable the engineering of peptide-MHCII (pMHCII) complexes for therapeutic and diagnostic applications.
Fei, Wen +3 more
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Frontiers in Immunology, 2019 Shedding of membrane-bound cell surface proteins, where the extracellular domain is released and found in the circulation is a common phenomenon. A prominent example is CEACAM5 (CEA, CD66e), where the shed domain plays a pivotal role in tumor progression
Jan P. Bogen +6 more
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Antibodies, 2019 To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern approach is to screen B cells by generating natively paired single chain variable fragment (scFv)
Angélica V. Medina-Cucurella +14 more
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Accounting for the Role of Long Walks on Networks via a New Matrix Function [PDF]
, 2016 We introduce a new matrix function for studying graphs and real-world networks based on a double-factorial penalization of walks between nodes in a graph. This new matrix function is based on the matrix error function.
Estrada, Ernesto, Silver, Grant
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Empirical study on clique-degree distribution of networks [PDF]
, 2007 The community structure and motif-modular-network hierarchy are of great importance for understanding the relationship between structures and functions. In this paper, we investigate the distribution of clique-degree, which is an extension of degree and ...
Bing-Hong Wang +9 more
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Yeast surface display for protein engineering and characterization
Current Opinion in Structural Biology, 2007 Yeast surface display is being employed to engineer desirable properties into proteins for a broad variety of applications. Labeling with soluble ligands enables rapid and quantitative analysis of yeast-displayed libraries by flow cytometry, while cell-surface selections allow screening of libraries with insoluble or even as-yet-uncharacterized binding
Gai, S Annie, Wittrup, K Dane
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Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library
BMC Biotechnology, 2012 Background Glypican-3 (GPC3) is a heparan-sulfate proteoglycan frequently expressed on the cell membrane of malignant hepatocytes in hepatocellular carcinoma.
Li Yonghai +3 more
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Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423
, 2018 Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit
Börsch, Michael +2 more
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