Cells expressing murine RAD52 splice variants favor sister chromatid repair [PDF]
, 2006 The RAD52 gene is essential for homologous recombination in the yeast Saccharomyces cerevisiae. RAD52 is the archetype in an epistasis group of genes essential for DNA damage repair.
Freeman, TC +5 more
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Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination [PDF]
Nucleic Acids Research, 1996 Hdf1 is the yeast homologue of the mammalian 70 kDa subunit of Ku-protein, which has DNA end-binding activity and is involved in DNA double-strand break repair and V(D)J recombination. To examine whether Hdf1 is involved in illegitimate recombination, we have measured the rate of deletion mutation caused by illegitimate recombination on a plasmid in an
Y, Tsukamoto, J, Kato, H, Ikeda
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Efficient gene targeting and foreign DNA removal by homologous recombination in the picoeukaryote Ostreococcus [PDF]
, 2014 With fewer than 8000 genes and a minimalist cellular organization, the green picoalga Ostreococcus tauri is one of the simplest photosynthetic eukaryotes. Ostreococcus tauri contains many plant-specific genes but exhibits a very low gene redundancy.
Bouget, Francois-Yves +8 more
core +1 more source
G3: Genes, Genomes, Genetics, 2018 Proper DNA damage repair is one of the most vital and fundamental functions of every cell. Several different repair mechanisms exist to deal with various types of DNA damage, in various stages of the cell cycle and under different conditions.
Alex Bronstein +4 more
doaj +1 more source
Isolation and characterization of "Arabidopsis" mutants with altered homologous recombination levels : a new function for an INO80 SWI/SNF ATPase [PDF]
, 2006 Homologous recombination (HR) in eukaryotic organisms serves a dual role in providing genetic flexibility by creating novel sequence assortments upon meiosis and in maintaining genome integrity through DNA repair in somatic tissues.
Fritsch, Olivier
core +1 more source
Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]
, 2015 In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Dal Peraro, Matteo +29 more
core +2 more sources
Transgenic mice expressing a human apolipoprotein[a] allele
Journal of Lipid Research, 1999 The most important determinant of plasma levels of Lp[a] are sequence differences at the highly polymorphic apolipoprotein[a] (apo[a]) locus. To define the sequences that mediate the regulation of apo[a] expression, we cloned a 370 kb DNA fragment that ...
Francesco Acquati +10 more
doaj +1 more source
Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation [PDF]
, 2005 In Trypanosoma brucei, DNA recombination is crucial in antigenic variation, a strategy for evading the mammalian host immune system found in a wide variety of pathogens.
Proudfoot, C +3 more
core +1 more source
Plant DNA Recombinases: A Long Way to Go
Journal of Nucleic Acids, 2010 DNA homologous recombination is fundamental process by which two homologous DNA molecules exchange the genetic information for the generation of genetic diversity and maintain the genomic integrity.
Rajani Kant Chittela +1 more
doaj +1 more source
The Fission Yeast BLM Homolog Rqh1 Promotes Meiotic Recombination [PDF]
Genetics, 2008 Abstract RecQ helicases are found in organisms as diverse as bacteria, fungi, and mammals. These proteins promote genome stability, and mutations affecting human RecQ proteins underlie premature aging and cancer predisposition syndromes, including Bloom syndrome, caused by mutations affecting the BLM protein.
Gareth A, Cromie +2 more
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