Results 261 to 270 of about 356,347 (342)
Additive manufacturing enables complex structures, but polymer printing often suffers from poor interlayer fusion and defects induced by heat or binders. A two‐step, room‐temperature strategy based on immersion phase separation (IPS‐E3DP) achieves precise liquid‐state fusion with high structural fidelity, enhanced mechanical performance, broad material
Kaidong Song+11 more
wiley +1 more source
Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization
Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay+3 more
wiley +1 more source
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan+5 more
wiley +1 more source
Comparison of MALDI-TOF MS instruments and databases for the identification of uncommon yeasts, <i>Aspergillus</i> spp. and rare filamentous fungi. [PDF]
Dutkiewicz M+11 more
europepmc +1 more source
Biomolecular Interaction Prediction: The Era of AI
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley +1 more source
Transforming non-conventional yeasts into key players in biotechnology: advances in synthetic biology applications. [PDF]
Moon SY, An NY, Lee JY.
europepmc +1 more source