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Yersinia pestis and Plague: Some Knowns and Unknowns

Zoonoses, 2023
Since its first identification in 1894 during the third pandemic in Hong Kong, there has been significant progress in understanding the lifestyle of Yersinia pestis , the pathogen that is responsible for plague.
Ruifu Yang, Steve Atkinson, Ziqi Chen, Yujun Cui, Zongmin Du, Yanping Han, Florent Sebbane, Philip Slavin, Yajun Song, Yanfeng Yan, Yarong Wu, Lei Xu, Chutian Zhang, Yun Zhang, B. Joseph Hinnebusch, Nils Chr. Stenseth, Vladimir L. Motin   +16 more
doaj   +2 more sources

Acquisition of yersinia murine toxin enabled Yersinia pestis to expand the range of mammalian hosts that sustain flea-borne plague.

PLoS Pathogens, 2021
Yersinia murine toxin (Ymt) is a phospholipase D encoded on a plasmid acquired by Yersinia pestis after its recent divergence from a Yersinia pseudotuberculosis progenitor. Despite its name, Ymt is not required for virulence but acts to enhance bacterial
David M Bland, Adélaïde Miarinjara, Christopher F Bosio, Jeanette Calarco, B Joseph Hinnebusch   +4 more
doaj   +2 more sources

The EnteroBase user's guide, with case studies on Salmonella transmissions, Yersinia pestis phylogeny and Escherichia core genomic diversity [PDF]

Genome Research, 2019
EnteroBase is an integrated software environment which supports the identification of global population structures within several bacterial genera that include pathogens.
Achtman, Mark, Alikhan, Nabil-Fareed, Fan, Yulei, HASH(0x5574f40a5930), Mohamed, Khaled, Tyne, William, Zhou, Zhemin   +6 more
core   +2 more sources

Yersinia pestis Interacts With SIGNR1 (CD209b) for Promoting Host Dissemination and Infection

Frontiers in Immunology, 2019
Yersinia pestis, a Gram-negative bacterium and the etiologic agent of plague, has evolved from Yersinia pseudotuberculosis, a cause of a mild enteric disease. However, the molecular and biological mechanisms of how Y. pseudotuberculosis evolved to such a
Kun Yang, Kun Yang, Yingxia He, Chae Gyu Park, Young Sun Kang, Pei Zhang, Yanping Han, Yujun Cui, Silvia Bulgheresi, Andrey P. Anisimov, Svetlana V. Dentovskaya, Xiaoling Ying, Lingyu Jiang, Honghui Ding, Olivia Adhiambo Njiri, Olivia Adhiambo Njiri, Shusheng Zhang, Guoxing Zheng, Lianxu Xia, Biao Kan, Xin Wang, Huaiqi Jing, Meiying Yan, Wei Li, Yuanzhi Wang, Xiding Xiamu, Gang Chen, Ding Ma, Sara Schesser Bartra, Gregory V. Plano, John D. Klena, Ruifu Yang, Mikael Skurnik, Tie Chen, Tie Chen   +34 more
doaj   +2 more sources

Inhibition of Neutrophil Primary Granule Release during Yersinia pestis Pulmonary Infection

mBio, 2019
Inhalation of Yersinia pestis causes primary pneumonic plague, the most severe manifestation of plague that is characterized by a dramatic neutrophil influx to the lungs.
Kara R. Eichelberger, Grant S. Jones, William E. Goldman   +2 more
doaj   +2 more sources

Ancient Yersinia pestis genomes from across Western Europe reveal early diversification during the First Pandemic (541–750)

Proceedings of the National Academy of Sciences of the United States of America, 2019
The first historically documented pandemic caused by Yersinia pestis began as the Justinianic Plague in 541 within the Roman Empire and continued as the so-called First Pandemic until 750.
Bates, J., Bos, K., Castex, D., Cessford, C., Durand, R., Haas-Gebhard, B., Haberstroh, J., Harbeck, M., Herbig, A., Inskip, S., Keller, M., Kivisild, T., Krause, J., Kröpelin, A., Lacomba, A., McCormick, M., Neumann, G., Nägele, K., Peters, J., Päffgen, B., Raynaud, C., Robb, J., Scheib, C., Spyrou, M., Stadler, P., Trautmann, B.   +25 more
core   +2 more sources

Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague

Nature Communications, 2018
Yersinia pestis has caused infections (plague) in humans since the Early Bronze Age (5000 years ago). Here, Spyrou et al. reconstruct Y. pestis genomes from Late Bronze Age individuals, and find genomic evidence compatible with flea-mediated transmission
Maria A. Spyrou, Rezeda I. Tukhbatova, Chuan-Chao Wang, Aida Andrades Valtueña, Aditya K. Lankapalli, Vitaly V. Kondrashin, Victor A. Tsybin, Aleksandr Khokhlov, Denise Kühnert, Alexander Herbig, Kirsten I. Bos, Johannes Krause   +11 more
doaj   +2 more sources

Review of genotyping methods for Yersinia pestis in Madagascar. [PDF]

PLoS Neglected Tropical Diseases
BackgroundPlague, a zoonotic disease caused by Yersinia pestis, was responsible for 3 historical human pandemics that killed millions of people. It remains endemic in rodent populations in Africa, Asia, North America, and South America but human plague ...
Lovasoa Nomena Randriantseheno, Voahangy Andrianaivoarimanana, Javier Pizarro-Cerdá, David M Wagner, Minoarisoa Rajerison   +4 more
doaj   +2 more sources

Interaction of the Yersinia pestis type III regulatory proteins LcrG and LcrV occurs at a hydrophobic interface. [PDF]

, 2002
BACKGROUND: Secretion of anti-host proteins by Yersinia pestis via a type III mechanism is not constitutive. The process is tightly regulated and secretion occurs only after an appropriate signal is received.
Jyl S. Matson, Matthew L. Nilles
openalex   +7 more sources

Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus [PDF]

bioRxiv, 2016
© Bos et al. The 14th-18th century pandemic of Yersinia pestis caused devastating disease outbreaks in Europe for almost 400 years. The reasons for plague's persistence and abrupt disappearance in Europe are poorly understood, but could have been due to ...
Bos, KI, Dutour, O, Forrest, SA, Fourment, M, Golding, GB, Herbig, A, Holmes, EC, Keim, P, Klunk, J, Krause, J, Kuch, M, Poinar, D, Poinar, HN, Sahl, J, Schuenemann, VJ, Waglechner, N, Wagner, DM   +16 more
core   +2 more sources