Results 101 to 110 of about 1,592,983 (303)

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells

Journal of Experimental & Clinical Cancer Research, 2019
Background Metformin has been reported to function as the anti-tumor inhibiting the growth of different types of cancers, including bladder cancer.
Yanju Wu, Qianqian Zheng, Yan Li, Guang Wang, Shuting Gao, Xiaodong Zhang, Xu Yan, Xinwen Zhang, Jisheng Xie, Yuanyuan Wang, Xun Sun, Xin Meng, Bo Yin, Biao Wang   +13 more
doaj   +1 more source

Novel components of the Toxoplasma inner membrane complex revealed by BioID. [PDF]

, 2015
UNLABELLED:The inner membrane complex (IMC) of Toxoplasma gondii is a peripheral membrane system that is composed of flattened alveolar sacs that underlie the plasma membrane, coupled to a supporting cytoskeletal network. The IMC plays important roles in
Bell, Hannah N, Bentolila, Laurent A, Bradley, Peter J, Chen, Allan L, Huang, Amy S, Kim, Elliot W, Moon, Andy S, Rashoff, Andrew Q, Toh, Justin Y, Van, Christina, Vashisht, Ajay A, Wohlschlegel, James A   +11 more
core   +3 more sources

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

Expression and clinical significance of FGL1 and YAP1 in colorectal cancer

Zhongguo linchuang yanjiu
Objective To investigate the expression characteristics and the reationship with clinical prognostic of fibrinogen-like protein 1（FGL1）and Yes-associated protein 1（YAP1）in colorectal cancer.
LIU Yuanming*，CUI Guangjie，CHEN Jiaqi，LU Yang，GAO Chao
doaj   +1 more source

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

Frontiers in Immunology, 2020
Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate immune responses in cancer. This study investigated the mechanisms by which lactate suppresses macrophage pro-inflammatory responses. Macrophages [Raw 264.7
Kun Yang, Kun Yang, Jingjing Xu, Min Fan, Min Fan, Fei Tu, Fei Tu, Xiaohui Wang, Tuanzhu Ha, Tuanzhu Ha, David L. Williams, David L. Williams, Chuanfu Li, Chuanfu Li   +13 more
doaj   +1 more source

Boolean analysis identifies CD38 as a biomarker of aggressive localized prostate cancer. [PDF]

, 2018
The introduction of serum Prostate Specific Antigen (PSA) testing nearly 30 years ago has been associated with a significant shift towards localized disease and decreased deaths due to prostate cancer.
Auman, Heidi, Brooks, James D, Carroll, Peter R, Fazli, Ladan, Feng, Ziding, Gleave, Martin E, Hurtado-Coll, Antonio, Leach, Robin J, Lin, Daniel W, McKenney, Jesse K, Nelson, Peter S, Sahoo, Debashis, Simko, Jeff, Thompson, Ian M, Troyer, Dean A, True, Lawrence D, Wei, Wei   +16 more
core   +2 more sources

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt, Eya Khadhraoui, Sebastian J. Müller, Katja Neumann, Hendrik Mattern, Sven G. Meuth, Valentina Perosa, Andreas Charidimou, Stefanie Schreiber   +8 more
wiley   +1 more source

Bioinformatic Analyses of Unique (Orphan) Core Genes of the Genus Acidithiobacillus: Functional Inferences and Use As Molecular Probes for Genomic and Metagenomic/Transcriptomic Interrogation [PDF]

, 2016
Indexación: Web of Science.Using phylogenomic and gene compositional analyses, five highly conserved gene families have been detected in the core genome of the phylogenetically coherent genus Acidithiobacillus of the class Acidithiobacillia.
Gonzalez, C, Holmes, DS, Lazcano, M, Valdes, J   +3 more
core   +1 more source

Differential expression of Yes-associated protein and phosphorylated Yes-associated protein is correlated with expression of Ki-67 and phospho-ERK in colorectal adenocarcinoma.

Histology and histopathology, 2013
Yes-associated protein (YAP) is a transcriptional co-activator and functions as a nuclear downstream effector of the Hippo pathway. Differential expression of YAP and phosphorylated Yes-associated protein (pYAP), which are involved in the expression of Ki-67 and phosphorylated extracellular signal-regulated kinase (pERK) in colorectal adenocarcinoma ...
Kim, Dong-Hoon, Kim, Seok-Hyung, Lee, Ok-Jun, Huang, Song-Mei, Kwon, Ju-Lee, Kim, Jin Man, Kim, Ji-Yeon, Seong, In Ock, Song, Kyu Sang, Kim, Kyung Hee   +9 more
openaire   +3 more sources