In Vitro Neurochemical Assessment of Methylphenidate and Its "Legal High" Analogs 3,4-CTMP and Ethylphenidate in Rat Nucleus Accumbens and Bed Nucleus of the Stria Terminalis [PDF]
, 2018 3,4-dichloromethylphenidate (3,4-CTMP) and ethylphenidate are new psychoactive substances and analogs of the attention deficit medication methylphenidate. Both drugs have been reported on online user fora to induce effects similar to cocaine.
Baumann +44 more
core +3 more sources
Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review
Food Frontiers, Volume 7, Issue 2, March 2026.ABSTRACT Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders.
Bruno Anderson F. Silva +9 more
wiley +1 more source
Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules
Magnetic Resonance in Chemistry, Volume 64, Issue 3, Page 286-311, March 2026.Plasma neutrophil elastase(ELANE) was markedly elevated in patients with alcohol use disorder, indicating a dysregulated protease‐antiprotease inflammatory balance characterised by decreased SERPINA3. ELANE showed excellent diagnostic specificity(AUC = 0.8683), supporting its potential utility as a neuroinflammatory biomarker for AUD.
Nilamoni Nath +3 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.ABSTRACT Anxiety is a multidimensional behavioral disorder widely studied in neuroscience due to the involvement of specific neural circuits. Although benzodiazepines are commonly used, their side effects drive the search for new therapeutic alternatives.
Nádia Aguiar Portela Pinheiro +11 more
wiley +1 more source
Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex [PDF]
, 2018 Background Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone “set the
Baker, David A. +10 more
core +1 more source
Plant-Environment Interactions, Volume 7, Issue 1, February 2026.ABSTRACT This study investigates the foliar secondary metabolite profiles of four Mitragyna species naturally occurring in Thailand: M. diversifolia, M. hirsuta, M. rotundifolia, and M. speciosa (kratom). Using untargeted gas chromatography–mass spectrometry (GC–MS), 409 secondary volatile metabolites were annotated across the four species.
Tushar Andriyas +5 more
wiley +1 more source
Acute effectiveness of a “fat-loss” product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise [PDF]
, 2015 Background: Achieving fat-loss outcomes by ingesting multi-ingredient mixtures may be further enhanced during exercise. This study tested the acute thermogenic effectiveness of a commercially available multi-ingredient product (Shred-Matrix®), containing
Alkhatib, Ahmad +3 more
core +6 more sources
Enhancement of psychosocial treatment with D-cycloserine: models, moderators, and future directions [PDF]
, 2016 Advances in the understanding of the neurobiology of fear extinction have resulted in the development of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure treatment.
de Kleine, Rianne A. +8 more
core +1 more source
Binding of [125I]Iodocyanopindolol by Rat Harderian Gland Crude Membranes: Kinetic Characteristics and Day-Night Variations [PDF]
, 1996 The Harderian glands are innervated by sympathetic fibers originating in the superior cervical ganglia. The aim of this study is to characterize the /3-adrenergic receptors in the rat Harderian gland.
Calvo Gutiérrez, Juan Ramón +4 more
core +1 more source
Mechanism of Selective Inhibition of Yohimbine and Its Derivatives in Adrenoceptor α2 Subtypes
Journal of Chemistry, 2013 Some natural alkaloids from medicinal plants, such as yohimbine and its derivatives, have been reported with adrenoceptor (AR) α2 subtypes inhibiting activity.
Liu Hai-Bo +4 more
doaj +1 more source