Results 61 to 70 of about 6,560 (173)
Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 257-266, May 2026.ABSTRACT The objectives of this study were to evaluate ATIP pharmacokinetics (PK) in healthy Beagle dogs after IM and IN dosing (Phase I), and to compare the rate of reversal of IM versus IN routes for xylazine (XYL) sedation (Phase II). This study was comprised of two sequential, randomized, crossover experiments. The initial PK study dosed ATIP by IN
Vanessa E. Cowan +7 more
wiley +1 more source
USE OF HERBAL MEDICINES IN PSYCHIATRY
Zdravniški Vestnik, 2001 Background. »Lost illusions« about conventionalmedicine, together with the orientation towards the »natural«way of life, lead into ever increasing use of alternative or complementaryways of treatment.
Blanka Kores Plesničar +1 more
doaj
ChemistryEurope, Volume 4, Issue 4, April 2026.We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas +7 more
wiley +1 more source
Rebreeding of Female Mountain Lions After Litter Mortality
Ecology and Evolution, Volume 16, Issue 4, April 2026.We documented rapid rebreeding by female mountain lions (Puma concolor) following litter loss, including the shortest known rebreeding interval to date. These observations highlight the importance of infanticide and intraguild competition in shaping female fitness and population dynamics.
Mark A. Peyton +3 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, Volume 50, Issue 4, April 2026.Alcohol‐associated cues renewed conditioned alcohol seeking when rats returned to the original conditioning context after extinction. Male and female rats showed comparable cue‐elicited approach and sipper contact, suggesting shared contextual memory retrieval mechanisms underlying relapse‐like behavior.
Taylor A. Simmons +6 more
wiley +1 more source
Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine
Equine Veterinary Education, Volume 38, Issue 4, Page 220-228, April 2026.Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell +4 more
wiley +1 more source
Postprandial Hypotension—Methods for the Evaluation and Management
Geriatrics &Gerontology International, Volume 26, Issue 4, April 2026.Postprandial hypotension (PPH) is highly prevalent in older patients; however, its diagnosis remains challenging due to the absence of a consensus guideline for diagnostic criteria. Lifestyle modification is the first‐line management, taking into account the pathophysiology underlying PPH and the coexisting conditions of orthostatic hypotension and ...
Joji Ishikawa +3 more
wiley +1 more source
Biological Psychiatry Global Open ScienceBackground: Intranasal administration of the neuropeptide oxytocin has been explored as a potential therapeutic agent for substance use disorder including opioid use disorder (OUD).
Brian J. Gully +7 more
doaj +1 more source
Mechanism of Selective Inhibition of Yohimbine and Its Derivatives in Adrenoceptor α2 Subtypes
Journal of Chemistry, 2013 Some natural alkaloids from medicinal plants, such as yohimbine and its derivatives, have been reported with adrenoceptor (AR) α2 subtypes inhibiting activity.
Liu Hai-Bo +4 more
doaj +1 more source
Molecules, 2013 A new indole alkaloid, 12-hydroxy-N-acetyl-21(N)-dehydroplumeran-18-oic acid (13), and 11 known indole alkaloids: 3,4,5,6-tetradehydro-β-yohimbine (3), 19(E)-hunteracine (4), b-yohimbine (5), yohimbine (6), 19,20-dehydro-17-a-yohimbine (7), uleine (10 ...
Adrian Martin Pohlit +7 more
doaj +1 more source