Results 51 to 60 of about 6,857 (173)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 35, 24 June 2026.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Emerging Treatments for Erectile Dysfunction

Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Erectile dysfunction (ED) is a prevalent condition that can significantly affect men's sexual health and quality of life, and for which there are many well‐studied effective treatments. In spite of this, many individuals still seek out alternative therapies.
Resa Magill, Jeff Morrison, Juan Andino, Jasper Bash   +3 more
wiley   +1 more source

USE OF HERBAL MEDICINES IN PSYCHIATRY

Zdravniški Vestnik, 2001
Background. »Lost illusions« about conventionalmedicine, together with the orientation towards the »natural«way of life, lead into ever increasing use of alternative or complementaryways of treatment.
Blanka Kores Plesničar, Barbara Razinger Mihovec   +1 more
doaj  

The Pupil‐Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics

Psychophysiology, Volume 63, Issue 6, June 2026.
ABSTRACT Spontaneous pupil fluctuations (SPFs) during rest provide a non‐invasive, low‐cost index of central arousal dynamics, independent of cognitive task demands. These features position SPFs as promising markers for baseline neurophysiological activity in both basic and translational research. This review synthesizes current evidence on the resting‐
T. Liu, S. A. Kotz, A. Criscuolo, M. Schwartze   +3 more
wiley   +1 more source

Genetic Identification of Potential Drug Targets for Dental Caries: A Mendelian Randomization Study

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Dental caries (DC), a chronic and multifactorial disease, affects billions of people globally, posing a significant public health challenge. Despite its prevalence, the molecular mechanisms underlying DC and effective pharmacological targets remain elusive.
Junlei Bi, Anqi Liu, Na Zhang, Yuxin Chen, Changqing Liu, Yongna Zhu, Hebao Wen, Caiyun Ma   +7 more
wiley   +1 more source

Comparative Pharmacokinetics of Intranasal or Intramuscular Atipamezole in Unsedated Dogs and Efficacy for Reversal of Xylazine Sedation

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 257-266, May 2026.
ABSTRACT The objectives of this study were to evaluate ATIP pharmacokinetics (PK) in healthy Beagle dogs after IM and IN dosing (Phase I), and to compare the rate of reversal of IM versus IN routes for xylazine (XYL) sedation (Phase II). This study was comprised of two sequential, randomized, crossover experiments. The initial PK study dosed ATIP by IN
Vanessa E. Cowan, Vanessa R. Mitcham, Deborah L. Michel, Chloe Lyons, Juliet Kennedy, Yoana C. Reyes Morales, Jennifer M. Loewen, Alan L. Chicoine   +7 more
wiley   +1 more source

Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids

ChemistryEurope, Volume 4, Issue 4, April 2026.
We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas, Eli S. Levit, Alexis A. Bragg, Taylor A. Gerrein, Khalil A. Abboud, Pingrong Wei, Lukasz M. Dobrzycki, Robert W. Huigens III   +7 more
wiley   +1 more source

Oxytocin Reduces Noradrenergic-Induced Opioid-Like Withdrawal Symptoms in Individuals on Opioid Agonist Therapy

Biological Psychiatry Global Open Science
Background: Intranasal administration of the neuropeptide oxytocin has been explored as a potential therapeutic agent for substance use disorder including opioid use disorder (OUD).
Brian J. Gully, Zoe E. Brown, Rivkah Hornbacher, Joshua C. Brown, Sudie E. Back, Elinore F. McCance-Katz, Robert M. Swift, Carolina L. Haass-Koffler   +7 more
doaj   +1 more source

Conversion of Yohimbine into beta-Yohimbine and 3-epi-beta-Yohimbine. [PDF]

Acta Chemica Scandinavica, 1957
W. O. Godtfredsen, S. Vangedal, M. Moutschen-Dahmen, B. Noer, L. Reio   +4 more
openaire   +1 more source

The Effect of Dorsal Hippocampal α2-Adrenegic Receptors on WIN55,212-2 State-Dependent Memory of Passive Avoidance

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2010
Background and Objectives: Cannabinoids are a class of psychoactive compounds that produce a wide array of effects in a large number of species. In the present study, the effects of bilateral intra-CA1 injections of an α2-adrenergic receptor agents,
M Piri, A Moshfegh, Sh Oryan, MR Zarrindast   +3 more
doaj