Results 51 to 60 of about 6,560 (173)
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity. [PDF]
PLoS ONE, 2015 The search for drugs with anorectic activity, acting within the adrenergic system has attracted the interest of researchers. Partial α2-adrenoceptor agonists might offer the potential for effective and safe treatment of obesity.
Magdalena Dudek +9 more
doaj +1 more source
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, Volume 13, Issue 35, 24 June 2026.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Emerging Treatments for Erectile Dysfunction
Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.ABSTRACT Erectile dysfunction (ED) is a prevalent condition that can significantly affect men's sexual health and quality of life, and for which there are many well‐studied effective treatments. In spite of this, many individuals still seek out alternative therapies.
Resa Magill +3 more
wiley +1 more source
Colloquium Agrariae, 2008 The amitraz is an acaricide and tickicide with adrenergic α2 action. The treatment of this intoxication consists on the use of α2 adrenergic antagonists, as yohimbine.
João Paulo Silva Smerdel +2 more
doaj +1 more source
Psychophysiology, Volume 63, Issue 6, June 2026.ABSTRACT Spontaneous pupil fluctuations (SPFs) during rest provide a non‐invasive, low‐cost index of central arousal dynamics, independent of cognitive task demands. These features position SPFs as promising markers for baseline neurophysiological activity in both basic and translational research. This review synthesizes current evidence on the resting‐
T. Liu +3 more
wiley +1 more source
BMC Research Notes, 2021 Objective The naked mole rat (NMR) (Heterocephalus glaber) is increasingly considered an important biomedical research model for various conditions like hypoxic brain injury, cancer and nociception.
R. M. Mwobobia +2 more
doaj +1 more source
Genetic Identification of Potential Drug Targets for Dental Caries: A Mendelian Randomization Study
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Dental caries (DC), a chronic and multifactorial disease, affects billions of people globally, posing a significant public health challenge. Despite its prevalence, the molecular mechanisms underlying DC and effective pharmacological targets remain elusive.
Junlei Bi +7 more
wiley +1 more source
CXII.—Yohimbine (quebrachine) [PDF]
J. Chem. Soc., Trans., 1915 n ...
Barger, George, Field, Ellen
openaire +2 more sources
Yohimbine bioavailability in humans [PDF]
European Journal of Clinical Pharmacology, 1990 Pharmacokinetic profiles were determined in seven healthy young male subjects following single oral and intravenous doses of 10 mg of yohimbine hydrochloride. The drug was rapidly eliminated (t1/2 beta 0.58 h orally and t1/2 beta 0.68 h intravenously).
Guthrie, Sally K. +2 more
openaire +3 more sources