Results 51 to 60 of about 14,193 (213)

α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment [PDF]

open access: yes, 2010
Slow-onset adaptive changes that arise from sustained antidepressant treatment, such as enhanced adult hippocampal neurogenesis and increased trophic factor expression, play a key role in the behavioral effects of antidepressants.
Bartlett, Perry   +12 more
core   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Mechanistic assessment of the analgesic, anti-inflammatory and antipyretic actions of Dalbergia saxatilis in animal models

open access: yesPharmaceutical Biology, 2017
Context: Aqueous root extract of Dalbergia saxatilis, Hook, f., (Leguminosae) (DS) is reported useful for toothache, pains, and fever, but not scientifically proven.
Omoniyi K. Yemitan   +1 more
doaj   +1 more source

an experimental approach with a trauma film paradigm [PDF]

open access: yes, 2016
Background Intrusive memories of traumatic events are a core feature of post- traumatic stress disorder but little is known about the neurobiological formation of intrusions.
Hellmann-Regen, J.   +5 more
core   +1 more source

Home range and core area characteristics of urban and rural coyotes and red foxes in southern Wisconsin

open access: yesWildlife Biology, EarlyView.
Second‐order habitat selection is influenced by a variety of factors, including individual‐ and species‐specific traits and resource requirements, as well as landscape characteristics. By comparing home range characteristics across individuals, species, and landscapes, we can draw conclusions regarding whether and how different factors influence home ...
Morgan J. Farmer   +4 more
wiley   +1 more source

Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain

open access: yesActa Veterinaria, 2018
Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist.
Katarina Savić Vujović   +7 more
doaj   +1 more source

Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol

open access: yesProteomes, 2018
Early life stress is associated with risk for developing alcohol use disorders (AUDs) in adulthood. Though the neurobiological mechanisms underlying this vulnerability are not well understood, evidence suggests that aberrant glucocorticoid and ...
Megan L. Bertholomey   +7 more
doaj   +1 more source

The role of BK potassium channels in analgesia produced by alpha-2 adrenergic receptors [PDF]

open access: yes, 2016
BACKGROUND AND OBJECTIVE: Millions of people suffer from pain worldwide, and annually, great economic costs are imposed on societies for pain relief. Analgesics such as alpha-2 adrenergic receptor agonists, which have low risk of complications, can be ...
Attarzadeh-Yazd, G.   +2 more
core   +1 more source

Noradrenergic stimulation enhances human action monitoring [PDF]

open access: yes, 2015
Noradrenergic neurotransmission has been associated with the modulation of higher cognitive functions mediated by the prefrontal cortex. In the present study, the impact of noradrenergic stimulation on the human action-monitoring system, as indexed by ...
Barbanoj, Manel J.   +4 more
core   +2 more sources

Anticoagulant Rodenticides Contribute to a Decline in an Urban Carnivore

open access: yesAnimal Conservation, EarlyView.
Anticoagulant rodenticides (ARs) have been shown to negatively affect carnivores globally and are closely tied to human activity and development. We examined drivers of annual survival in bobcats persisting on a residentially developed barrier island over 16 years.
Meghan P. Keating   +7 more
wiley   +1 more source

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