Results 31 to 40 of about 6,560 (173)

Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice

Frontiers in Aging Neuroscience, 2022
Background: Inflammation promotes the progression of Alzheimer’s disease (AD). In this study, we explored the effect of dexmedetomidine on inflammation and cognitive function in a mouse model of AD.Methods: 5xFAD mice were intragastrically administered ...
Su-mei Luo, Long-yan Li, Long-yan Li, Li-zhe Guo, Lu Wang, Yan-feng Wang, Na Chen, E. Wang, E. Wang   +8 more
doaj   +1 more source

Determination of content of indole alkaloids in cell biomass of Rauwolfia serpentina Benth. ex Kurz tissue culture

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021
Cardiovascular diseases are the most common human diseases, hence, the production of cardiological (in particular, anti-arrhythmic) medications from the natural sources is an ever-actual task. Rauwolfia serpentina Benth.
O. A. Bieda, I. I. Konvaliuk, L. P. Mozhylevska, S. S. Lukashov, V. A. Kunakh, S. M. Yarmoluk   +5 more
doaj   +1 more source

Development of an improved anesthesia protocol to increase CF1 mice survival in a portal vein infection with Echinococcus granulosus sensu lato protoscoleces

Heliyon, 2021
In order to optimize the survival rate of animals, the purpose of this study was to evaluate an injectable anesthesia protocol for the development of a murine model of hepatic cystic echinococcosis in female CF-1 mice.
Nathalia P. Scioscia, Patricia E. Pensel, Guillermo M. Denegri, María Celina Elissondo   +3 more
doaj   +1 more source

Impact of tobacco smoke constituents on nicotine-seeking behavior in adolescent and adult male rats

Frontiers in Psychiatry, 2023
IntroductionGiven the rapid increase in teen vaping over recent years it is critical to understand mechanisms underlying addiction and relapse to tobacco use at this age.
Candice A. Gellner, Diana Carreño, James D. Belluzzi, Frances M. Leslie   +3 more
doaj   +1 more source

Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic Receptor [PDF]

Iranian Journal of Veterinary Surgery, 2020
Objective- Medicinal plants and their active constituents are frequently used components for treating hyperglycemia. In the present study, the effect of curcumin was investigated on acute hyperglycemia and hyperinsulinemia induced by ketamine-xylazine in
Esmaeal Tamaddonfard, Amir Erfanparast, Sina Tamaddonfard, Nabat Nagshbandi, Somayyeh Naderi   +4 more
doaj   +1 more source

EFFECTS OF YOHIMBINE ON PLASMA LEVELS OF LEPTIN IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS [PDF]

Acta Medica Iranica, 2006
Leptin affects paraventricular nucleus of hypothalamus and reduces appetite while activation of α2-adrenoceptors at this site has opposite action.
M. Mohammadi Naghadeh, F. Homayouni Moghadam, H. Ibrahimi   +2 more
doaj   +2 more sources

Modeling [11C]yohimbine PET human brain kinetics with test-retest reliability, competition sensitivity studies and search for a suitable reference region

NeuroImage, 2021
Previous work introduced the [11C]yohimbine as a suitable ligand of central α2-adrenoreceptors (α2-ARs) for PET imaging. However, reproducibility of [11C]yohimbine PET measurements in healthy humans estimated with a simplified modeling method with ...
Chloé Laurencin, Sophie Lancelot, Florent Gobert, Jérôme Redouté, Inés Mérida, Thibault Iecker, François Liger, Zacharie Irace, Elise Greusard, Ludovic Lamberet, Didier Le Bars, Nicolas Costes, Bénédicte Ballanger   +12 more
doaj   +1 more source

Locus coeruleus lesions and PCOS: role of the central and peripheral sympathetic nervous system in the ovarian function of rat [PDF]

Iranian Journal of Reproductive Medicine, 2012
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction”. “Autonomic and central nervous systems play important roles in the regulation of ovarian physiology”.
Farideh Zafari Zangeneh, Alireza Abdollahi, Fatemeh Aminee, Mohammad Mahdi Naghizadeh   +3 more
doaj  

Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol

Proteomes, 2018
Early life stress is associated with risk for developing alcohol use disorders (AUDs) in adulthood. Though the neurobiological mechanisms underlying this vulnerability are not well understood, evidence suggests that aberrant glucocorticoid and ...
Megan L. Bertholomey, Kathryn Stone, TuKiet T. Lam, Seojin Bang, Wei Wu, Angus C. Nairn, Jane R. Taylor, Mary M. Torregrossa   +7 more
doaj   +1 more source

Efeitos hemogasométricos da xilazina e da romifidina em cabras tratadas por ioimbina Haemogasometric effects of xylazine and romifidine in goats treated with yohimbine

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2005
Estudaram-se as alterações produzidas por doses equipotentes de xilazina e romifidina e os efeitos da administração subseqüente de ioimbina em oito cabras mestiças.
J.A.B. Bastos, F.O. Paes Leme, G.E.S. Alves   +2 more
doaj   +1 more source