Results 11 to 20 of about 6,560 (173)

A literature perspective on the pharmacological applications of yohimbine

Annals of Medicine, 2022
Introduction: Phytochemicals have garnered much attention because they are useful in managing several human diseases. Yohimbine is one such phytochemical with significant pharmacological potential and could be exploited for research by medicinal chemists.
Nasimudeen R Jabir, Chelapram K Firoz, Torki A Zughaibi   +2 more
exaly   +3 more sources

Unveiling bioactive compounds in kola nut seeds: GC-MS identification and computational analysis for anticancer potential [PDF]

Frontiers in Nutrition
IntroductionCancer continues to pose a critical global health challenge, with conventional therapies often limited by efficacy and adverse side effects.
Azzah Alshehri, Azzah Alshehri, Azzah Alshehri, Saleh Bahaffi, Mohd Rehan, Mohd Rehan, Mohd Suhail, Mohd Suhail, Ahmed I. Al-Asmari, Ahmed I. Al-Asmari, Diaa T. A. Youssef, Diaa T. A. Youssef, Alaa Khedr, Alaa Khedr, Torki Zughaibi, Torki Zughaibi   +15 more
doaj   +2 more sources

Berberine ameliorates acute hyperglycemia and hypoinsulinemia induced by ketamine/xylazine in rats: role of alpha2 adrenergic receptors, oxidative stress and inflammatory suppressing mechanisms [PDF]

BMC Veterinary Research
Background Xylazine is a common veterinary drug used for sedation, anesthesia, muscle relaxation and analgesia. Berberine (C20H18NO4 +) is an alkaloid compound found in different plant species with a wide range of biological and pharmacological ...
Rusul Abdulhameed Kadhim, Amir Erfanparast, Esmaeal Tamaddonfard, Davoud Amirkashani, Mehdi Imani   +4 more
doaj   +2 more sources

Comparative efficacy of yohimbine and tolazoline for antagonism of ketamine-xylazine induced sedation in captive wild felids [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021
This study was conducted to investigate the comparative efficacy of yohimbine and tolazoline for antagonism of ketamine-xylazine induced sedation in captive wild felids in Pakistan.
Ameer Hamza RABBANI, Yasir Razzaq KHAN, Omer NASEER, Kashif HUSSEIN, Ahmad ALI, Abdul WAHEED, Muhammad SHAHID, Hareem AFZAL   +7 more
doaj   +3 more sources

Inhibition of α2-adrenoceptor is renoprotective in 5/6 nephrectomy-induced chronic kidney injury rats

Journal of Pharmacological Sciences, 2021
In the present study, we investigated the renoprotective effects of long-term treatment with yohimbine, an α2-adrenoceptor inhibitor, in a 5/6 nephrectomy-induced chronic kidney disease (CKD) rat model.
Kohei Hayashi, Takaomi Shimokawa, Masayo Yamagata, Kozo Yoneda   +3 more
doaj   +1 more source

Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis

Urology Research and Practice, 2021
In recent years, several studies have reported promising results of Yohimbine as a natural supplement for erectile dysfunction (ED). However, several studies suggested that the aphrodisiac effects of the extract were only a placebo or due to the increase
Dwi Nanda Satriyo Arif Wibowo, Doddy Moesbadianto Soebadi, Mohammad Ayodhia Soebadi   +2 more
doaj   +1 more source

Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches. [PDF]

Chem Biodivers
ABSTRACT Cinnamaldehyde (CA), a major component of Cinnamomum spp. essential oils, has recognized bioactivity, including possible analgesic effects. However, its acute antinociceptive mechanisms remain unclear. This study assessed the influence of CA (15, 30, and 60 mg/kg, p.o.) on locomotor and exploratory behaviors via rotarod and open field tests in
Rêgo RIA, Pires HFO, Dias AL, Remigio MCRB, de Andrade HHN, da Silva PR, de Sousa NF, Scotti L, Scotti MT, Salvadori MGSS, de Castro RD.   +10 more
europepmc   +2 more sources

Successful reversal of a rare case of amitraz poisoning with yohimbine—a case report

Ain Shams Journal of Anesthesiology, 2022
Background Amitraz is an insecticidal agent and its poisoning cases are rare. We report the successful treatment of amitraz poisoning using yohimbine as an antidote. There is only a single other case report in literature of usage of yohimbine as antidote
Ankur Gupta, Achint Narang, Nikhil Shandilya, Aman Sharma, Rahul Kathuria, Aakriti Gupta   +5 more
doaj   +1 more source

Yohimbine Alleviates Oxidative Stress and Suppresses Aerobic Cysteine Metabolism Elevated in the Rat Liver of High-Fat Diet-Fed Rats

Molecules, 2023
Yohimbine is a small indole alkaloid derived from the bark of the yohimbe tree with documented biological activity, including anti-inflammatory, erectile dysfunction relieving, and fat-burning properties.
Małgorzata Iciek, Magdalena Górny, Magdalena Kotańska, Anna Bilska-Wilkosz, Marta Kaczor-Kamińska, Jacek Zagajewski   +5 more
doaj   +1 more source

Yohimbine-Induced Reactivity of Heart Rate Variability in Unmedicated Depressed Patients With and Without Adverse Childhood Experience

Frontiers in Psychiatry, 2021
Stressful life events play a role in the pathogenesis of major depressive disorder (MDD) and many patients with MDD were exposed to developmental stress due to adverse childhood experiences (ACE).
Christian Eric Deuter, Christian Otte, Katja Wingenfeld, Linn Kristina Kuehl, Linn Kristina Kuehl   +4 more
doaj   +1 more source