Results 41 to 50 of about 14,193 (213)

The impact of yohimbine-induced arousal on facets of behavioural impulsivity [PDF]

, 2012
Rationale State-dependent changes in physiological arousal may influence impulsive behaviours. Objectives To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α2-adrenergic receptor antagonist, which ...
Herman, Aleksandra M, Critchley, Hugo D, Duka, Theodora   +2 more
core   +1 more source

Impact of tobacco smoke constituents on nicotine-seeking behavior in adolescent and adult male rats

Frontiers in Psychiatry, 2023
IntroductionGiven the rapid increase in teen vaping over recent years it is critical to understand mechanisms underlying addiction and relapse to tobacco use at this age.
Candice A. Gellner, Diana Carreño, James D. Belluzzi, Frances M. Leslie   +3 more
doaj   +1 more source

Modeling [11C]yohimbine PET human brain kinetics with test-retest reliability, competition sensitivity studies and search for a suitable reference region

NeuroImage, 2021
Previous work introduced the [11C]yohimbine as a suitable ligand of central α2-adrenoreceptors (α2-ARs) for PET imaging. However, reproducibility of [11C]yohimbine PET measurements in healthy humans estimated with a simplified modeling method with ...
Chloé Laurencin, Sophie Lancelot, Florent Gobert, Jérôme Redouté, Inés Mérida, Thibault Iecker, François Liger, Zacharie Irace, Elise Greusard, Ludovic Lamberet, Didier Le Bars, Nicolas Costes, Bénédicte Ballanger   +12 more
doaj   +1 more source

Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]

, 2015
Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P., Kantak, Kathleen M., Somkuwar, Sucharita S.   +2 more
core   +1 more source

Yohimbine-induced amygdala activation in pathological gamblers: a pilot study. [PDF]

PLoS ONE, 2012
There is evidence that drug addiction is associated with increased physiological and psychological responses to stress. In this pilot functional magnetic resonance imaging (fMRI) study we assessed whether a prototype behavioral addiction, pathological ...
Igor Elman, Lino Becerra, Evelyne Tschibelu, Rinah Yamamoto, Edward George, David Borsook   +5 more
doaj   +1 more source

α_1L-adrenoceptors mediate contraction of human erectile tissue [PDF]

, 2018
α1-adrenoceptor antagonists can impact upon sexual function and have potential in the treatment of erectile dysfunction. Human erectile tissue contains predominantly α1A-adrenoceptors, and here we examined whether contractions of this tissue are mediated
Campbell, Alistair, Chapple, Christopher R., Chess-Williams, Russ, Davis, Beverley J., Naylor, Alisdair L., Sellers, Donna J., Sillar, David   +6 more
core   +1 more source

Locus coeruleus lesions and PCOS: role of the central and peripheral sympathetic nervous system in the ovarian function of rat [PDF]

Iranian Journal of Reproductive Medicine, 2012
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction”. “Autonomic and central nervous systems play important roles in the regulation of ovarian physiology”.
Farideh Zafari Zangeneh, Alireza Abdollahi, Fatemeh Aminee, Mohammad Mahdi Naghizadeh   +3 more
doaj  

ESTUDO DA REVERSÃO DA INTOXICAÇÃO EXPERIMENTAL POR AMITRAZ POR VIA TÓPICA EM GATOS COM O USO DE IOIMBINA

Colloquium Agrariae, 2008
The amitraz is an acaricide and tickicide with adrenergic α2 action. The treatment of this intoxication consists on the use of α2 adrenergic antagonists, as yohimbine.
João Paulo Silva Smerdel, Vinicius David Zamberlan, Silvia Franco Andrade   +2 more
doaj   +1 more source

Neurobiological Mechanisms That Contribute to Stress-related Cocaine Use [PDF]

, 2014
The ability of stressful life events to trigger drug use is particularly problematic for the management of cocaine addiction due to the unpredictable and often uncontrollable nature of stress.
Ahmed, Ahmed, Ambroggi, Amphoux, Asanuma, Back, Badrinarayan, Barik, Beckerman, Beckstead, Behan, Berridge, Blacktop, Brady, Briand, Brischoux, Broadbear, Brown, Brown, Bruijnzeel, Buffalari, Butts, Campioni, Capriles, Chen, Cintra, Coffey, Conrad, Cottler, Day, de Jong, de Kloet, De La Garza, De Vries, Deroche-Gamonet, Dobi, Dong, Duan, Dumont, Duncan, Egli, Engel, Erb, Erb, Erb, Erb, Erb, Erb, Feltenstein, Forray, Fox, Fox, Galici, Gasser, Gasser, Geisler, Georges, Ghitza, Goeders, Gonzalez-Islas, Gorboulev, Graf, Graf, Gründemann, Hahn, Harfstrand, Iversen, Jayme R. McReynolds, Jennings, Jobes, John R. Mantsch, Jordan M. Blacktop, Kalivas, Kash, Kippin, Koob, Koob, Korotkova, Kreibich, Kudo, Lee, Leri, Lewis, Lodge, Lê, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, McEwen, McFarland, Nobis, Oleson, Oliver Vranjkovic, Orio, Ostrander, Paul J. Gasser, Preston, Rainbow, Redila, Refojo, Ribeiro Do Couto, Riegel, Robert C. Twining, Rodaros, Roitman, Rounsaville, Saal, Sanchez, Sartor, Schulkin, Seamans, Shaham, Shaham, Shaham, Shalev, Shelton, Shields, Shin, Silberman, Sinha, Sinha, Sinha, Smith, Specio, Steffensen, Tagliaferro, Tasker, Ungless, Ungless, Ungless, Van Pett, Vialou, Vranjkovic, Wanat, Wang, Wang, Wang, Wang, Ward, Wee, Wee, Wei, Wellman, Wise, Yamaguchi, Zahm, Zoli   +149 more
core   +2 more sources

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source