Results 41 to 50 of about 6,560 (173)

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Home range and core area characteristics of urban and rural coyotes and red foxes in southern Wisconsin

Wildlife Biology, EarlyView.
Second‐order habitat selection is influenced by a variety of factors, including individual‐ and species‐specific traits and resource requirements, as well as landscape characteristics. By comparing home range characteristics across individuals, species, and landscapes, we can draw conclusions regarding whether and how different factors influence home ...
Morgan J. Farmer, Timothy R. Van Deelen, Daniel J. Storm, Marcus A. Mueller, David Drake   +4 more
wiley   +1 more source

Yohimbine-induced amygdala activation in pathological gamblers: a pilot study. [PDF]

PLoS ONE, 2012
There is evidence that drug addiction is associated with increased physiological and psychological responses to stress. In this pilot functional magnetic resonance imaging (fMRI) study we assessed whether a prototype behavioral addiction, pathological ...
Igor Elman, Lino Becerra, Evelyne Tschibelu, Rinah Yamamoto, Edward George, David Borsook   +5 more
doaj   +1 more source

Anticoagulant Rodenticides Contribute to a Decline in an Urban Carnivore

Animal Conservation, EarlyView.
Anticoagulant rodenticides (ARs) have been shown to negatively affect carnivores globally and are closely tied to human activity and development. We examined drivers of annual survival in bobcats persisting on a residentially developed barrier island over 16 years.
Meghan P. Keating, Catherine M. Bodinof Jachowski, Duane R. Diefenbach, James D. Jordan, Nicole M. Nemeth, Thomas R. Rainwater, Gregory K. Yarrow, David S. Jachowski   +7 more
wiley   +1 more source

Dexmedetomidine Rapidly Relieves Stress‐Induced Hyperalgesia via Presynaptic α2‐Adrenergic Inhibition at Orbitofrontal–Insular Glutamatergic Synapses

MedComm, Volume 7, Issue 7, July 2026.
This study identified a maladaptive OFC–AIC glutamatergic circuit in stress‐induced hyperalgesia induction. This critical circuit provides an α2‐AR‐dependent braking target for dexmedetomidine to alleviate excessive glutamatergic transmission and hyperalgesia. ABSTRACT Dexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, is widely used for
Hui Rong, Yang‐Xun Zhang, Huijie Zhu, Yinyao Li, Yunfan Hou, Yun‐Yong Xie, Lu‐Yao Li, Bei‐Bei Zhang, Shu‐Tao Xie, Wei Zhang, Qi‐Peng Zhang, Xiao‐Yang Zhang, Jing‐Ning Zhu, Xiaoping Gu, Zhengliang Ma   +14 more
wiley   +1 more source

A Multispecies Systematic and Critical Review of Intranasal Administration in Veterinary Anaesthesia and Emergency Care: Promising Evidence and Overlooked Challenges

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
This review evaluates the clinical potential and limitations of intranasal (IN) drug administration in veterinary anaesthesia and emergency care. IN delivery can provide clinically relevant sedation, analgesia and drug reversal, but its success is not universally reliable and is strongly influenced by species‐specific anatomy, formulation ...
Majid Jafarbeglou
wiley   +1 more source

Comparison of Seda‐Block and Xylazine–Ketamine Anaesthesia for Metacarpal and Radioulnar Osteosynthesis in Calves

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
This abstract illustrates two bovine anaesthesia techniques: the brachial plexus block, which targets nerve roots at the shoulder and intravenous regional anaesthesia (IVRA), which uses a tourniquet and venous injection. Both methods provide effective distal forelimb analgesia for clinical and field surgical procedures in calves.
Mümin Gökhan Şenocak, Çağlar Özkalipçi, Taner Arslan, Yasemin Akçora, Tuğçe Kartal, Cüneyt Türkmen, Büşra Baykal, Sıtkıcan Okur, Ayşe Gölgeli Bedir, Ferda Turgut, Yakup Kocaman, Ömer Tarık Orhun, Uğur Ersöz, Elif Doğan, Latif Emrah Yanmaz   +14 more
wiley   +1 more source

Mechanistic assessment of the analgesic, anti-inflammatory and antipyretic actions of Dalbergia saxatilis in animal models

Pharmaceutical Biology, 2017
Context: Aqueous root extract of Dalbergia saxatilis, Hook, f., (Leguminosae) (DS) is reported useful for toothache, pains, and fever, but not scientifically proven.
Omoniyi K. Yemitan, Olufunmilayo O. Adeyemi   +1 more
doaj   +1 more source

The Orexin System Modulates Stress‐Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence

Addiction Biology, Volume 31, Issue 7, July 2026.
Chronic foot stress increases the vulnerability of adolescent mice to alcohol addiction‐related behaviours. Acute foot stress promotes the recovery of alcohol‐seeking behaviour in adolescent mice and increases orexin concentrations in the hippocampus, nucleus accumbens and prefrontal cortex.
Wenhao He, Aqian Hu, Tianshu Zhao, Li Deng, Huilin Wu, Xiaojun Xiang   +5 more
wiley   +1 more source

Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain

Acta Veterinaria, 2018
Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist.
Katarina Savić Vujović, Sonja Vučković, Radan Stojanović, Nevena Divac, Branislava Medić, Dragana Srebro, Marko Kadija, Milica Prostran   +7 more
doaj   +1 more source