Results 41 to 50 of about 6,857 (173)
Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.This review evaluates the clinical potential and limitations of intranasal (IN) drug administration in veterinary anaesthesia and emergency care. IN delivery can provide clinically relevant sedation, analgesia and drug reversal, but its success is not universally reliable and is strongly influenced by species‐specific anatomy, formulation ...
Majid Jafarbeglou
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.This abstract illustrates two bovine anaesthesia techniques: the brachial plexus block, which targets nerve roots at the shoulder and intravenous regional anaesthesia (IVRA), which uses a tourniquet and venous injection. Both methods provide effective distal forelimb analgesia for clinical and field surgical procedures in calves.
Mümin Gökhan Şenocak +14 more
wiley +1 more source
A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity. [PDF]
PLoS ONE, 2015 The search for drugs with anorectic activity, acting within the adrenergic system has attracted the interest of researchers. Partial α2-adrenoceptor agonists might offer the potential for effective and safe treatment of obesity.
Magdalena Dudek +9 more
doaj +1 more source
Alcohol, Clinical and Experimental Research, Volume 50, Issue 7, July 2026.Alcohol and stress during adolescence may lead to long‐lasting impairments in risky decision‐making. We show that adolescent ethanol or yohimbine exposure selectively reduces cautious risk assessment without changing anxiety‐like behaviors, reorganizing behavioral structure.
Beatriz Deo Sorigotto +2 more
wiley +1 more source
Addiction Biology, Volume 31, Issue 7, July 2026.Chronic foot stress increases the vulnerability of adolescent mice to alcohol addiction‐related behaviours. Acute foot stress promotes the recovery of alcohol‐seeking behaviour in adolescent mice and increases orexin concentrations in the hippocampus, nucleus accumbens and prefrontal cortex.
Wenhao He +5 more
wiley +1 more source
Colloquium Agrariae, 2008 The amitraz is an acaricide and tickicide with adrenergic α2 action. The treatment of this intoxication consists on the use of α2 adrenergic antagonists, as yohimbine.
João Paulo Silva Smerdel +2 more
doaj +1 more source
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
BMC Research Notes, 2021 Objective The naked mole rat (NMR) (Heterocephalus glaber) is increasingly considered an important biomedical research model for various conditions like hypoxic brain injury, cancer and nociception.
R. M. Mwobobia +2 more
doaj +1 more source
Journal of Neurochemistry, Volume 170, Issue 7, July 2026.Understanding the congruent effects of different types of antidepressant treatments on sensitive brain regions, such as the hippocampus and cortex, can highlight essential mechanisms of action. We used a systematic meta‐analysis of public transcriptional profiling datasets to identify genes and functional gene sets that are differentially expressed ...
Eva M. Geoghegan +11 more
wiley +1 more source
Yohimbine bioavailability in humans [PDF]
European Journal of Clinical Pharmacology, 1990 Pharmacokinetic profiles were determined in seven healthy young male subjects following single oral and intravenous doses of 10 mg of yohimbine hydrochloride. The drug was rapidly eliminated (t1/2 beta 0.58 h orally and t1/2 beta 0.68 h intravenously).
Guthrie, Sally K. +2 more
openaire +3 more sources