Palmitoylation of the Frizzled-5 receptor and its role in Wnt signalling and synapse assembly [PDF]
Synapses are critical microstructures required for many brain functions. Thus, the proper formation of synapses is an integral developmental process. Wnts are secreted proteins that promote synapse assembly through Frizzled (Fz) receptors. In particular,
Teo, Zhi Yao Samuel
core
S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling [PDF]
, 2018 Genetic investigations have demonstrated that a specific form of axonal branching - the bifurcation of afferents from dorsal root ganglia (DRG), cranial sensory ganglia (CSG) and mesencephalic trigeminal neurons (MTN) – is regulated by a cGMP-dependent ...
Alexandre Dumoulin +3 more
core +6 more sources
Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2). [PDF]
, 2014 The NAD-synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is a critical survival factor for axons and its constant supply from neuronal cell bodies into axons is required for axon survival in primary culture neurites and axon
Coleman, Michael P, Milde, Stefan
core +1 more source
The landscape of renal protein S-acylation in mice with lipid-induced nephrotoxicity [PDF]
Excess fat intake is associated with kidney toxicity and dysfunction. Because fatty acids can also be reversibly attached onto cysteine residues and modulate the function of several membrane-bound proteins, we studied the effect of high-fat diet (HFD) on
Gai, Zhibo +5 more
core +1 more source
Depalmitoylation regulates metabolism and mitochondrial function [PDF]
Tens of millions of Americans suffer from metabolic disorders, predisposing patients to cardiovascular disease, kidney disease, liver disease, infertility, and cancer.
Speck, Sarah Lilly
core +1 more source
SPATIAL TRANSCRIPTOMICS UNRAVELS PALMITOYLATION AND ZONATION- DEPENDENT GENE REGULATION OF AEG-1 IN MOUSE LIVER [PDF]
Obesity-induced metabolic dysfunction-associated steatohepatitis (MASH) leads to hepatocellular carcinoma (HCC). Astrocyte-elevated gene-1/Metadherin (AEG-1/MTDH) plays a key role in promoting MASH and HCC.
Saverino, Alissa
core +1 more source
Regulation of calcium signalling in murine corticotrophs [PDF]
, 2019 Anterior pituitary corticotrophs, the central components of the hypothalamic-pituitaryadrenal (HPA) axis, are important for controlling the neuroendocrine response to stress.
Deng, Mengdie
core
FUNCTIONAL ROLES FOR POST-TRANSLATIONAL MODIFICATIONS OF t-SNARES IN PLATELETS [PDF]
, 2016 Platelets affect vascular integrity by secreting a host of molecules that promote hemostasis and its sequela. Given its importance, it is critical to understand how platelet exocytosis is controlled.
Zhang, Jinchao
core +1 more source
Quantitative analysis of protein lipidation and acyl-CoAs reveals substrate preferences of the S -acylation machinery [PDF]
Protein palmitoylation or S-acylation has emerged as a key regulator of cellular processes. Increasing evidence shows that this modification is not restricted to palmitate but it can include additional fatty acids, raising the possibility that ...
Blanco-Canosa, Juan B. +7 more
core
ZDHHC20 Activates AKT Signaling Pathway to Promote Cell Proliferation in Hepatocellular Carcinoma [PDF]
Xiaoju Huang,1– 3 Mengmeng Wang,1– 3 Dan Zhang,1– 3 Junpeng Meng,4,5 Pian Liu1– 3 1Cancer Center Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Hubei Key Laboratory of ...
Huang X, Liu P, Meng J, Wang M, Zhang D
core +1 more source