Results 111 to 120 of about 481 (138)

ZDHHC-Mediated Protein S-Palmitoylation in Cancer: Epigenetic Interfaces, Structural Logic and Therapeutic Targeting

International Journal of Medical Sciences
Xinyi Chen, Duo Xu, Yongbiao Huang, Xianglin Yuan   +3 more
openaire   +1 more source

Systematic analysis of ZDHHC9 as a potential prognostic and immunotherapy biomarker in breast cancer. [PDF]

Front Immunol
Zhou D, Wu Z, Cui Y, Wang D, Song H, Chen J, Lin H.   +6 more
europepmc   +1 more source

M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation. [PDF]

Signal Transduct Target Ther
Zhang MY, Ji DN, Qi WY, Wang S, Dai CY, Xu FY, Dong Z, Xiong C, Zhang BW, Wang Y, Guo XF, Zhang B, Cheng WZ, Zhang XY, Jin SD, Guan XX, Hong H, Zhou T, Li SF, Zhang R, Sun LH, Xuan LN, Jiang Y, Yang BF, Xu CQ.   +24 more
europepmc   +1 more source

Enrichment of Cysteine S-palmitoylated Peptides Using Sodium Deoxycholate Acid Precipitation. [PDF]

Mol Cell Proteomics
Jensen PT, Palmisano G, Rhodes CJ, Larsen MR.   +3 more
europepmc   +1 more source

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Palmitoyl transferase zDHHCs: novel targets in Alzheimer’s disease

Alzheimer's and Dementia, 2023
AbstractBackgroundGrowing evidence points to altered metabolic signals as a risk factor for Alzheimer’s disease (AD). The high fatty acid levels and brain insulin resistance (BIR) found in AD brains may impinge on protein S‐palmitoylation, which is a post‐translational modification critically involved in the regulation of neuronal protein localization ...
Salvatore Fusco, Francesca Natale, Matteo Spinelli, Walter Gulisano, Marco Rinaudo, Daniela Puzzo, Claudio Grassi   +6 more
exaly   +2 more sources

Bump-hole ZDHHCs

Nature Chemical Biology
Bryan Dickinson
exaly   +2 more sources

Access and utilization of long chain fatty acyl-CoA by zDHHC protein acyltransferases

Current Opinion in Structural Biology, 2022
S-acylation is a reversible posttranslational modification, where a long-chain fatty acid is attached to a protein through a thioester linkage. Being the most abundant form of lipidation in humans, a family of twenty-three human zDHHC integral membrane enzymes catalyze this reaction. Previous structures of the apo and lipid bound zDHHCs shed light into
Robbins Puthenveetil, Natalia Gómez-Navarro, Anirban Banerjee   +2 more
openaire   +2 more sources

In Vitro Assays to Monitor the Enzymatic Activities of zDHHC Protein Acyltransferases

2019
A family of zDHHC protein acyltransferase (PAT) enzymes catalyze the S-palmitoylation of target proteins via a two-step mechanism. The first step involves transfer of palmitate from the palmitoyl-CoA donor to the active site cysteine of the zDHHC PAT enzyme, releasing reduced CoA (CoASH).
David A, Mitchell, Laura C, Pendleton, Robert J, Deschenes   +2 more
openaire   +2 more sources

Identification and subcellular localization of TcHIP, a putative Golgi zDHHC palmitoyl transferase of Trypanosoma cruzi

Experimental Parasitology, 2013
Protein palmitoylation is a post-translational modification that contributes to determining protein localization and function. Palmitoylation has been described in trypanosomatid protozoa, but no zDHHC palmitoyl transferase has been identified in Trypanosoma cruzi, the etiological agent of Chagas disease in Latin America.
Cassiano Martin, Batista, Ligia Cristina, Kalb, Claudia Maria do Nascimento, Moreira, Guilherme Tadashi Hono, Batista, Iriane, Eger, Maurilio José, Soares   +5 more
openaire   +2 more sources

Bioinformatics Analysis of ZDHHC-protein Acyltransferase for Predicting the Rupture of Aneurysmal Subarachnoid Hemorrhage

Current Neurovascular Research
Introduction: Intracranial aneurysms (IAs) can cause life-threatening subarachnoid hemorrhage upon rupture, yet their molecular mechanisms remain poorly understood. Proteins encoded by the ZDHHC genes mediate protein palmitoylation and are involved in brain injury processes, but their relationship with IA ...
Wanjing, Zhang, Lu, Liu, Yajun, Hou, Weiqi, Wang   +3 more
openaire   +2 more sources