Results 71 to 80 of about 490 (156)

Defective anterograde protein-trafficking contributes to endoplasmic reticulum-stress in a CLN1 disease model

Neurobiology of Disease
Lysosomal storage disorders (LSDs) represent 70 inherited metabolic diseases, in most of which neurodegeneration is a devastating manifestation. The CLN1 disease is a fatal neurodegenerative LSD, caused by inactivating mutations in the CLN1 gene encoding
Nisha Plavelil, Abhilash P. Appu, K.C. Gopal, Avisek Mondal, Neil Perkins, Anil B. Mukherjee   +5 more
doaj   +1 more source

Pharmacological Targeting of DHHC9‐Mediated STRN4 Palmitoylation to Suppress YAP‐Driven Cancer Metastasis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Protein S‐palmitoylation, a dynamic and reversible post‐translational modification involving the attachment of palmitate to cysteine residues, is a key regulator of protein functionality and cellular signalling. Dysregulation of this modification has emerged as a critical driver of cancer progression.
Yang Tian, Wei Li, Qing Zhai, Ying Yu, Jiaxin Yuan, Yan Ma, Jingjing Yang, Mingyue Li, Wenwen Chang, Wenjing Li, Keke Huang, Chongran Sun, Chen Zeng, Yingdi Sun, Jiabao Gu, Huilin Zhang, Dameng Li, Yanan Yu, Lu Hu, Peng Zhang, Bo Ma, Junnian Zheng, Pan Li, Feng Guo, Yang Sun   +24 more
wiley   +1 more source

Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain [PDF]

, 2019
Host interferon-induced transmembrane proteins (IFITMs) are broad-spectrum antiviral restriction factors. Of these, IFITM3 potently inhibits viruses that enter cells through acidic endosomes, many of which are zoonotic and emerging viruses with bats ...
Benfield, C T O, Holmes, E C, Kellam, P, MacKenzie, F, Marsh, M, Mazzon, M, Ritzefeld, M, Smith, S E, Tate, E, Teo, B H, Weston, S   +10 more
core   +3 more sources

Multi‐Omics Mendelian Randomization Identifies a DNA Methylation‐ZDHHC20‐Immune Axis Associated With Schizophrenia Risk

Brain and Behavior, Volume 15, Issue 8, August 2025.
ABSTRACT Background Schizophrenia is a severe psychiatric disorder with a complex etiology involving genetic and environmental factors. Despite its profound impact, the molecular mechanisms underlying schizophrenia remain elusive. Emerging evidence suggests that DNA methylation, palmitoylation, and immune cell activity play critical roles in its ...
Qinghua Guo, Chao Chen, Yong Wang, Libo Guo, Shaomei Shang   +4 more
wiley   +1 more source

S-acylation of the Wnt receptor Frizzled-5 by zDHHC5 controls its cellular localization and synaptogenic activity in the rodent hippocampus [PDF]

, 2023
Proper localization of receptors for synaptic organizing factors is crucial for synapse formation. Wnt proteins promote synapse assembly through Frizzled (Fz) receptors. In hippocampal neurons, the surface and synaptic localization of Fz5 is regulated by
Bossio, Alessandro, Jones, Megan E, Pascual-Vargas, Patricia, Salinas, Patricia C, Schuhmacher, Laura-Nadine, Stamatakou, Eleanna, Teo, Samuel   +6 more
core  

Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme [PDF]

, 2020
A robust body of evidence supports the concept that phosphodiesterase 10A (PDE10A) activity in the basal ganglia orchestrates the control of coordinated movement in human subjects.
Baillie, George S., Brandon, Nicholas J., Bürli, Roland W., Deeb, Tarek Z., Moss, Stephen J., Sheridan, Eamonn, Tejeda, Gonzalo S., Whiteley, Ellanor L.   +7 more
core   +1 more source

TLR9‐Driven S‐Palmitoylation in Dendritic Cells Reveals Immune and Metabolic Protein Targets

European Journal of Immunology, Volume 55, Issue 8, August 2025.
Click chemistry–based proteomics revealed dynamic remodeling of the S‐palmitoylated proteome in dendritic cells upon TLR9 activation. Transcriptomics identified TLR9‐driven regulation of ZDHHC genes, including Zdhhc9. Genetic approaches uncovered potential ZDHHC9‐dependent targets.
Juan N. Quiroz, Malte Sielaff, Daria Kondrateva, Fatima Boukhallouk, Gloria J. Godoy, Cecilia R. Molina, Brecht Moonen, Claudia C. Motran, Jeroen Bogie, Hugo D. Luján, Stefan Tenzer, Tim Sparwasser, Luciana Berod   +12 more
wiley   +1 more source

The X‐Linked Intellectual Disability Gene, ZDHHC9 , Is Important for Oligodendrocyte Subtype Determination and Myelination

Glia, Volume 73, Issue 7, Page 1452-1466, July 2025.
Main Points Zdhhc9 ablation grossly changes gene expression and myelin protein levels in CNS WM. Zdhhc9 is important for the establishment of mature oligodendrocyte subtypes. Zdhhc9 is important for axon myelination and the maintenance of myelin integrity.
Rocio B. White, Angela R. Wild, Timothy P. O'Leary, Andrew J. Thompson, Stephane Flibotte, Angie Peng, Jason C. Rogalski, Mila Mair, Neeki Derhami, Shernaz X. Bamji   +9 more
wiley   +1 more source

First Steps toward the Design of Peptides that Influence the Intracellular Palmitoylation Machinery

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Herein, DC peptides consisting of the cell‐penetrating peptide sC18* and a Asp–His–His–Cys (DHHC) motif derived from human ZDHHC palmitoyltransferase are highlighted. DC peptides demonstrate high cellular internalization into various cellular models, exert cytotoxic effects against cancerous cells, and alter the function and localization of known ...
Katharina Stillger, Eric Platz‐Baudin, Florian Friedland, Melina Ruppel, Coco‐Louisa Sticker, Anne Bodenhausen, Erik Noetzel, Ines Neundorf   +7 more
wiley   +1 more source

Toward the identification of ZDHHC enzymes required for palmitoylation of viral protein as potential drug targets

Expert Opinion on Drug Discovery, 2019
Introduction: S-acylation is the attachment of fatty acids not only to cysteines of cellular, but also of viral proteins. The modification is often crucial for the protein´s function and hence for virus replication. Transfer of fatty acids is mediated by one or several of the 23 members of the ZDHHC family of proteins.
Gadalla, Mohamed Rasheed, Veit, Michael
openaire   +2 more sources