Results 81 to 90 of about 490 (156)

Posttranslational Modification in Bone Homeostasis and Osteoporosis

MedComm, Volume 6, Issue 4, April 2025.
This review summarizes the updating researches concerning bone formation and bone resorption mediated by different types of posttranslational modification. We highlight dysregulated posttranslational modification in osteoblast and osteoclast differentiation. We then emphasize involvement of posttranslational modification in osteoporosis development, so
Yuzhe Lin, Shide Jiang, Yuming Yao, Hengzhen Li, Hongfu Jin, Guang Yang, Bingzhou Ji, Yusheng Li   +7 more
wiley   +1 more source

Novel chemical genetic tools for the proteomic profiling of S-acylation by ZDHHC enzymes

, 2023
Post-translational modifications (PTM) represent the largest source of proteome diversity, regulating the function and fate of almost every eukaryotic protein. One of these is S-acylation, which refers to the post-translational covalent attachment of long-chain fatty acids onto thiol groups in surface-exposed cysteine residues.
openaire   +3 more sources

Protein palmitoylation: biological functions, disease, and therapeutic targets

MedComm, Volume 6, Issue 3, March 2025.
This review focuses on the role of protein palmitoylation in neurological disorders, with an emphasis on biological function and therapeutic targets. ZDHHC protein mediated palmitoylation is strongly implicated in epilepsy, MDD, ID, and SCZ, and in addition, enzymes that mediate palmitoylation may be novel targets in the treatment of neurological ...
Yan‐Ran Qian, Yu‐Jia Zhao, Feng Zhang   +2 more
wiley   +1 more source

Palmitoylation by ZDHHC family members regulate B-cell lymphoma growth

International Journal of Biological Macromolecules
The ZDHHC palmitoyl transferase family consists of 24 members, of which several have been linked to the development of cancer. We previously showed that inhibition of ZDHHC11 decreased growth of several B-cell lymphoma subtypes. In this study, we evaluated the effect of protein palmitoylation on the proteome in general and investigated expression and ...
Liu, Yichen, Hu, Shiyun, Önder, Özlem, Sahasrabuddhe, Anagh, Rajabi, Ali, Seitz, Annika, de Jong, Debora, Koerts, Jasper, Visser, Lydia, Dzikiewicz-Krawczyk, Agnieszka, Lim, Megan S, Elenitoba-Johnson, Kojo S, van den Berg, Anke, Ziel-Swier, Lotteke J Y M, Kluiver, Joost   +14 more
openaire   +1 more source

Dietary Palmitic Acid Drives a Palmitoyltransferase ZDHHC15‐YAP Feedback Loop Promoting Tumor Metastasis

Advanced Science, Volume 12, Issue 6, February 10, 2025.
This study uncovers that dietary palmitic acid (PA) acts as a potent inducer of YAP signaling in metastasis in breast and ovarian cancers, which is achieved by increasing the expression of palmitoyltransferase ZDHHC15, which in turn palmitoylates KIBRA and forms a feedback loop with YAP.
Jianxin Wang, Dachuan Shen, Jian Jiang, Lulu Hu, Kun Fang, Chunrui Xie, Ning Shen, Yuzhao Zhou, Yifei Wang, Sha Du, Songshu Meng   +10 more
wiley   +1 more source

Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity [PDF]

, 2019
Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics.
Dhrubajyoti Chowdhury, Johannes W. Hell, Karam Kim, Lucas Matt   +3 more
core   +1 more source

S-Acylation controls functional coupling of BK channel pore-forming α-subunits and β1-subunits [PDF]

, 2019
The properties and physiological function of pore-forming α-subunits of large conductance calcium- and voltage-activated potassium (BK) channels are potently modified by their functional coupling with regulatory subunits in many tissues.
Bi, Danlei, Chen, Lie, Duncan, Peter, McClafferty, Heather, Shipston, Michael, Tian, Lijun   +5 more
core   +1 more source

Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis [PDF]

, 2023
Metastasis is one of the defining features of pancreatic ductal adenocarcinoma (PDAC) that contributes to poor prognosis. In this study, the palmitoyl transferase ZDHHC20 was identified in an in vivo shRNA screen as critical for metastatic outgrowth ...
Baggelaar, Marc, Downward, Julian, Herbert, Eleanor, Ocasio, Cory A., Priestnall , Simon L., Refermat, Alice Y., Sheridan, Clare, Sipthorp, James, Sudarshan, Bhuvana, Suárez-Bonnet, Alejandro, Tate, Edward W., Tomic, Goran   +11 more
core  

Structure, Function, and Inhibition of Protein Depalmitoylases [PDF]

, 2018
Proteins are often regulated through the addition of chemical modifications that modulate localization, activity, and interactions. Protein S-palmitoylation describes the attachment of long-chain fatty acids to cysteine residues in proteins to promote ...
Won, Sang Joon
core  

Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment [PDF]

Protein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage.
Lei Wu, Yijiao Chen, Yongsheng Li
core   +1 more source