Results 51 to 60 of about 27,793 (201)

Single‐centre analysis of severe Coombs‐positive autoimmune haemolytic anaemia in an HIV‐endemic population

HIV Medicine, EarlyView.
Abstract Introduction Human immunodeficiency virus (HIV) is a rare cause of autoimmune haemolytic anaemia (AIHA) which requires prompt diagnosis and treatment. We compared clinical and laboratory findings in AIHA patients with and without HIV. Methods We included adults with severe AIHA (haemoglobin ≤8 g/dL) diagnosed at a tertiary academic centre ...
Kathleen O. De John, Karryn Brown, Jenna Bailey, Estelle R. Verburgh, Jessica J. Opie   +4 more
wiley   +1 more source

Reversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration

Biological Research, 2009
The development and validation of a simple and accurate method based on HPLC with ultraviolet detection for the quantification of zidovudine in rat plasma and its application to a pharmacokinetic study following a single intranasal dose zidovudine is ...
RUBIANA M MAINARDES, MARIA PALMIRA D. GREMIÃO   +1 more
doaj  

Systemic and local antibiotics in the management of peri‐implantitis: A systematic review and network meta‐analysis

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is a biofilm‐induced inflammatory condition with challenging management due to the complexity of implant surface topographies and the polymicrobial and well‐structured profile of the biofilm colonizing these surfaces.
Jamil A. Shibli, Vittorio Moraschini, Khalila C. Cotrim, Valentim A. R. Barão, Wim Teughels, Thabet Asbi, Daniela F. Bueno, Anton Sculean, João Gabriel S. Souza   +8 more
wiley   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

The Effects of Compulsory Licensing: A Case Study of HIV Drugs

Health Economics, Volume 35, Issue 10, Page 1427-1434, October 2026.
ABSTRACT Compulsory licensing is a legal mechanism that allows governments the use of patented medicines without the owner's consent, subject to conditions and compensation, to meet public‐health needs. Despite its policy relevance and increasing use, empirical evidence on its market effects remains limited.
Nicolau Martin‐Bassols, Miquel Serra‐Burriel, Kerstin Noelle Vokinger   +2 more
wiley   +1 more source

Lamivudine/abacavir maintains virological superiority over zidovudine/lamivudine and zidovudine/abacavir beyond 5 years in children [PDF]

, 2007
: Objective: To describe the long-term efficacy over 5 years of regimens including combinations of abacavir, lamivudine and/or zidovudine in previously untreated children in the PENTA 5 trial. Design: PENTA 5 was a 48-week randomised controlled trial
COMPAGNUCCI A, LEVY J, FEITERNA SPERLING C, BUTLER K, WALKER AS, WINTERGERST U, GIBB DM, GIAQUINTO, CARLO, SAIDI Y, DE ROSSI, ANITA, HARPER L, CANDEIAS E, CASTELLI GATTINARA G, PILLAY D, DELLA NEGRA M, Paediatric European Network for the Treatment of AIDS, GREEN H   +16 more
core  

The pattern of mucocutaneous disorders in pediatric HIV patients in a tertiary care center

Indian Journal of Paediatric Dermatology, 2020
Background: Dermatological manifestations constitute one of the most common clinical features in HIV-infected children. An early recognition of such features is important for an early diagnosis and also to assess the prognosis of HIV infection. Objective:
Sanjith Saravanabhavan, Seethalakshmi Ganga Vellaisamy, Kannan Gopalan, Muthusamy Kandasamy   +3 more
doaj   +1 more source

Assessment of Knowledge and Attitudes Toward Potential Drug–Drug and Drug–Food Interactions and Associated Factors Among Health Care Professionals at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims The increased likelihood of potential drug–drug interactions (PDDIs) and food–drug interactions (FDIs) is primarily attributed to the increasing use of multiple medications and the practice of taking medicines with food. Healthcare professionals' (HCPs') knowledge and attitudes toward PDDIs and FDIs play a critical role in ...
Melese Legesse Mitku, Yeniewa Kerie Anagaw, Abera Dessie Dagnaw, Derso Teju Geremew, Yeshiwas Ayale Ferede, Tewodros Denekew Haile, Minichil Chanie Worku, Liknaw Workie Limenh, Azmeraw Bekele, Wondim Ayenew   +9 more
wiley   +1 more source