Results 51 to 60 of about 60,681 (284)

DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD DETERMINATION OF ZIDOVUDINE ENCAPSULATED IN PCL NANOPARTICLES

Drug Analytical Research, 2017
A reversed-phase high-performance liquid chromatographic (HPLC) method was developed and validated for the determination of encapsulation efficiency of zidovudine in nanoparticules. The method was carried out in isocratic mode using 0.040M sodium acetate:
Milena Cristina Ribeiro Souza Magalhães, Alisson Samuel Portes Caldeira, Hanna de Sousa Rocha Almeida, Sílvia Ligório Fialho, Armando da Silva Cunha Junior   +4 more
doaj   +1 more source

Comparing genotoxic signatures in cord blood cells from neonates exposed in utero to zidovudine or tenofovir

AIDS (London), 2015
Objectives:Zidovudine and tenofovir are the two main nucleos(t)ide analogs used to prevent mother-to-child transmission of HIV. In vitro, both drugs bind to and integrate into human DNA and inhibit telomerase.
A. Vivanti, T. Soheili, W. Cuccuini, Sonia Luce, L. Mandelbrot, Jérôme Lechenadec, A. Cordier, E. Azria, J. Soulier, M. Cavazzana, S. Blanche, I. André-Schmutz   +11 more
semanticscholar   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Idiopathic intracranial hypertension associated with anaemia, secondary to antiretroviral drug in a human immunodeficiency virus positive patient

Indian Journal of Ophthalmology, 2018
Papilledema in a patient with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome is an alarming finding. Any condition giving rise to raised intracranial tension (ICT) can cause papilledema, and in these patients, it could be ...
J Vijay Ananth, S Sudharshan, Ambika Selvakumar, Bella J Devaleenal, Kavitha Kalaivani, Jyotirmay Biswas   +5 more
doaj   +1 more source

Top-Down Synthesis of a Lamivudine-Zidovudine Nano Co-Crystal

Crystals, 2020
Lamivudine (3TC) and zidovudine (AZT) are antiretroviral agents used to manage HIV/AIDS infection. A wet media milling top-down approach was used to develop and produce nano co-crystals of 3TC and AZT.
Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker   +2 more
doaj   +1 more source

Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes

Pharmacology Research & Perspectives, 2022
UDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed because of
Kaoru Kobayashi, Tsuneo Deguchi, Satoshi Abe, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Atsushi Kurihara, Mitsuo Oshimura, Yasuhiro Kazuki   +9 more
doaj   +1 more source

Positive Outcomes of HAART at 24 Months in HIV-Infected Patients in Cambodia. [PDF]

, 2007
OBJECTIVES: African and Asian cohort studies have demonstrated the feasibility and efficacy of HAART in resource-poor settings. The long-term virological outcome and clinico-immunological criteria of success remain important questions.
Bartlett, Bartlett, Bourgeois, Calmy, Calmy, Carrieri, Carrieri, Coetzee, Colebunders, Colebunders, Dabis, Ferradini, Gill, Gonzalez de, Grabar, Ivers, Kumarasamy, Laurent, Laurent, Lawn, Lawn, Lawn, Le Moing, Ly, Madec, Marzolini, Orrell, Pasquier, Rouet, Rouzioux, Severe, Tassie, Van Heeswijk, Weidle, Wu, Zhou   +35 more
core   +2 more sources

Engaging the public in plant science: Communication facilitators and barriers of scaling up a citizen science campaign

People and Nature, EarlyView.
Abstract Volunteers have been involved in nature observations for decades through citizen science initiatives, providing large data sets as well as problem identification that allow a more complete understanding of many natural phenomena. Although communication is a core component in citizen science, the key factors that determine its effectiveness in ...
Kristiina Gibson, Monika Suškevičs, Baiba Prūse, Marta Barberis, Sara A. O. Cousins, Živa Fišer, Margaux Julien, Marianne Kivastik, Marcin Klisz, Attila Lengyel, Zuzana Münzbergová, Radosław Puchałka, Iris Reinula, Froukje Rienks, Julie Koch Sheard, Viktor Siverin, Bojana Stojanova, Sabrina Träger, Tsipe Aavik   +18 more
wiley   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

A risk-factor guided approach to reducing lactic acidosis and hyperlactatemia in patients on antiretroviral therapy. [PDF]

PLoS ONE, 2011
Stavudine continues to be used in antiretroviral treatment (ART) regimens in many resource-limited settings. The use of zidovudine instead of stavudine in higher-risk patients to reduce the likelihood of lactic acidosis and hyperlactatemia (LAHL) has not
Lynn T Matthews, Janet Giddy, Musie Ghebremichael, Jane Hampton, Anthony J Guarino, Aba Ewusi, Emma Carver, Karen Axten, Meghan C Geary, Rajesh T Gandhi, David R Bangsberg   +10 more
doaj   +1 more source