Results 51 to 60 of about 25,606 (215)

Systemic and local antibiotics in the management of peri‐implantitis: A systematic review and network meta‐analysis

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is a biofilm‐induced inflammatory condition with challenging management due to the complexity of implant surface topographies and the polymicrobial and well‐structured profile of the biofilm colonizing these surfaces.
Jamil A. Shibli, Vittorio Moraschini, Khalila C. Cotrim, Valentim A. R. Barão, Wim Teughels, Thabet Asbi, Daniela F. Bueno, Anton Sculean, João Gabriel S. Souza   +8 more
wiley   +1 more source

Reversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration

Biological Research, 2009
The development and validation of a simple and accurate method based on HPLC with ultraviolet detection for the quantification of zidovudine in rat plasma and its application to a pharmacokinetic study following a single intranasal dose zidovudine is ...
RUBIANA M MAINARDES, MARIA PALMIRA D. GREMIÃO   +1 more
doaj  

Impact and efficacy of systemic antibiotics for peri‐implant diseases treatment: A systematic review and meta‐analysis on clinical and microbiological outcomes

Periodontology 2000, EarlyView.
Abstract Aim To evaluate the adjunctive effects of systemic antibiotics (SA) on clinical and microbiological outcomes in the treatment of peri‐implant diseases. Materials and Methods A systematic review and meta‐analysis were conducted following PRISMA guidelines and registered on PROSPERO (CRD420251059056).
Gaetano Isola, Alessandro Polizzi, Angela Angjelova, Elena Jovanova, Giuseppe Pizzo, Anton Sculean   +5 more
wiley   +1 more source

Safety and efficacy of lamivudine-zidovudine combination therapy in zidovudine-experienced patients: A randomized controlled comparison with zidovudine monotherapy

, 1996
Objective. - To compare the safety and efficacy of 2 doses of lamivudine given in combination with zidovudine with continued zidovudine monotherapy. Design.
Loveday, Clive, Staszewski, Schlomo, Picazo, Juan J., McDade, Hugh, Harrigan, P. Richard, Dellamonica, Pierre, Johnson, Margaret A., Verity, Lucy, Skinhøj, Peter, Danner, Sven A., Hill, Andrew M.   +10 more
core   +1 more source

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co‐Infected With HIV

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background HIV co‐infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first‐line anti‐TB drugs and clinical outcomes in patients with and without HIV co‐infection. Methods In this prospective observational study, 61 adults with sputum‐positive pulmonary TB, either confirmed ...
Aung Pyae Phyo, Richard M. Hoglund, Makoto Saito, Sein Sein Thi, Lei Lei Swe, Palang Chotsiri, Htet Ko Ko Aung, Win Pa Pa Tun, Banyar Maung Maung, Chanapat Pateekham, Wanitda Watthanaworawit, Gornpan Gornsawun, Nicholas J. White, Francois Nosten, Joel Tarning   +14 more
wiley   +1 more source

Tenofovir or zidovudine in second-line antiretroviral therapy after stavudine failure in southern Africa [PDF]

, 2014
BACKGROUND There is debate over using tenofovir or zidovudine alongside lamivudine in second-line antiretroviral therapy (ART) following stavudine failure.
Orrell, Catherine, Egger, Matthias, Gerber, Florian, Zwahlen, Marcel, Hoffmann, Christopher J, Gsponer, Thomas, Chimbetete, Cleophas, Wandeler, Gilles, Chi, Benjamin H, Prozesky, Hans, Boulle, Andrew, Rohr, Julia, Fox, Matthew P, Africa, Iedea Southern   +13 more
core   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

The pattern of mucocutaneous disorders in pediatric HIV patients in a tertiary care center

Indian Journal of Paediatric Dermatology, 2020
Background: Dermatological manifestations constitute one of the most common clinical features in HIV-infected children. An early recognition of such features is important for an early diagnosis and also to assess the prognosis of HIV infection. Objective:
Sanjith Saravanabhavan, Seethalakshmi Ganga Vellaisamy, Kannan Gopalan, Muthusamy Kandasamy   +3 more
doaj   +1 more source

Can Multiple Sclerosis be Managed Over a Lifetime? A Rare 72‐Year Journey of Pediatric‐Onset to Secondary Progressive Multiple Sclerosis

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system characterized by cumulative neurological disability over time. Median survival from symptom onset in large cohort studies is approximately four decades, although substantially prolonged disease courses are uncommon.
Masoud Etemadifar, Ahmadreza Dehghani, Mahdi Rahimi, Amirhossein Ghandehari, Mehri Salari   +4 more
wiley   +1 more source