Results 81 to 90 of about 60,681 (284)

THE STUDY OF INFLUENCE OF PREPARATION «COMBIVIR» ON CARBOHYDRATE AND LIPID METABOLISM OF BLOOD SERUM

Современная наука и инновации, 2022
The purpose of this study was to evaluate the effect of the drug «Combivir» on indicators of carbohydrate metabolism and serum lipids in the systemic toxicity study conducted in conditions of chronic experiment.
Elena Olegovna Sergeeva, Lubov Anatolievna Sadjaya, Alexander Yurievich Terekhov   +2 more
doaj  

Association of Tenofovir Use With Risk of Incident Heart Failure in HIV-Infected Patients. [PDF]

, 2017
BackgroundThe antiretroviral medication, tenofovir disoproxil fumarate (TDF), is used by most human immunodeficiency virus-infected persons in the United States despite higher risks of chronic kidney disease.
Chen, Ruijun, Estrella, Michelle M, Grunfeld, Carl, Horberg, Michael A, Hsue, Priscilla Y, Jotwani, Vasantha, Scherzer, Rebecca, Shlipak, Michael G   +7 more
core   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

A rare case report of severe aplastic anaemia caused by long-term use of zidovudine

BMC Infectious Diseases
Background Zidovudine is an antiviral drug used to treat acquired immune deficiency syndrome (AIDS). Anaemia is a common adverse effect of zidovudine that usually occurs in the first 2 to 4 weeks of initial treatment. Here, we describe a patient with HIV
Jing Zhou, Qi Wang, Yu’e Yu, Lingling Chen, Jinchuan Shi, Congxiang Huang, Rangxiao Zhuang   +6 more
doaj   +1 more source

Clinical Study to Evaluate Drug Interactions of Cannabidiol with Citalopram and Morphine in Healthy Adults

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1095-1104, April 2026.
Cannabidiol (CBD) is one of the most abundant bioactive cannabinoids. Research has demonstrated CBD’s ability to inhibit metabolic enzymes like cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT), potentially leading to drug interactions. However, clinical knowledge gaps remain, particularly with regard to drugs that are more commonly taken by ...
Pablo Salcedo, Donna A. Volpe, Anik Chaturbedi, Aanchal Shah, Ashok Krishna, Paula L Hyland, Giri Vegesna, Cheng‐Hui Hsiao, Ryan De Palma, Melanie Fein, Rodney Rouse, Jeffry Florian   +11 more
wiley   +1 more source

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, Volume 46, Issue 4, Page 1076-1082, April 2026.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

Quantitative Economic Evaluations of HIV-Related Prevention and Treatment Services: A Review [PDF]

, 1994
Dr. Holtgrave and colleagues at the CDC set forth an extensive taxonomy of HIV prevention and treatment services and review reports of efforts to subject some of those services to formal economic evaluation.
Holtgrave, David R., Valdiserri, Ronald O., West, Gary A.   +2 more
core   +2 more sources

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

The combination of arsenic, interferon-alpha, and zidovudine restores an “immunocompetent-like” cytokine expression profile in patients with adult T-cell leukemia lymphoma

Retrovirology, 2013
BackgroundHTLV-I associated adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis due to chemo-resistance and immuno-compromised micro-environment. The combination of zidovudine and interferon-alpha (IFN) significantly improved survival in ATL.
G. Kchour, S. Rezaee, R. Farid, A. Ghantous, H. Rafatpanah, M. Tarhini, M. Kooshyar, Hiba El Hajj, Fadwa Berry, M. Mortada, Roudaina Nasser, A. Shirdel, Zeina Dassouki, M. Ezzedine, H. Rahimi, A. Ghavamzadeh, H. de Thé, O. Hermine, M. Mahmoudi, A. Bazarbachi   +19 more
semanticscholar   +1 more source

Functionalized Cyclic Beta‐Amino Acid Derivatives With Antiviral Potential

ChemMedChem, Volume 21, Issue 6, 27 March 2026.
Selected highly functionalized cyclic beta (β)‐amino acid derivatives have been synthesized according to modified and improved literature synthetic protocols and subjected to various antiviral studies. The model compounds were regio‐ and stereoisomers of azido‐functionalized β‐amino esters, orthogonally protected diamino esters, an oxirane‐fused cyclic
Melinda Nonn, Marta Denel‐Bobrowska, Balázs Volk, Agnieszka B. Olejniczak, Loránd Kiss   +4 more
wiley   +1 more source