Results 71 to 80 of about 78,106 (261)
Advanced Science, EarlyView.Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun +6 more
wiley +1 more source
An optimal control model for COVID‐19, zika, dengue, and chikungunya co‐dynamics with reinfection
Optimal control applications & methods, 2022 The co‐circulation of different emerging viral diseases is a big challenge from an epidemiological point of view. The similarity of symptoms, cases of virus co‐infection, and cross‐reaction can mislead in the diagnosis of the disease.
A. Omame, Mary Ele Isah, M. Abbas
semanticscholar +1 more source
High‐elevation endemic plants predicted to lose habitat from changing climate in Washington State
American Journal of Botany, EarlyView.Abstract Premise High‐elevation plants face unique challenges from potential climate change impacts that will likely require upslope migration into increasingly smaller suitable habitat. This situation is particularly acute for endemic species that by definition occupy small geographic ranges.
Nicholas L. Gjording +4 more
wiley +1 more source
On the first Serbian translation of de legibus and de republica
Zbornik Radova Pravnog Fakulteta u Splitu, 2006 The universal intellectual and statesman Marcus Tulius Cicero had an outstanding knowledge of the law and legal sciences. The subject is Cicero's reports in his documents De re publica and De legibus observed from dual standpoints as capital sources for ...
Žika Bujuklić
doaj
Synthesis of 4′-Substituted-2′-Deoxy-2′-α-Fluoro Nucleoside Analogs as Potential Antiviral Agents
Molecules, 2020 Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies.
Mahesh Kasthuri +8 more
doaj +1 more source
JAMA pediatrics, 2020 Importance The number of children who were born to mothers with Zika virus (ZIKV) infection during pregnancy but who did not have apparent disability at birth is large, warranting the study of the risk for neurodevelopmental impairment in this population
S. Mulkey +11 more
semanticscholar +1 more source
Humanized immune system animal models and their recent applications
Animal Models and Experimental Medicine, EarlyView.In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli +6 more
wiley +1 more source
Zika and Flavivirus Shell Disorder: Virulence and Fetal Morbidity
Biomolecules, 2019 Zika virus (ZIKV) was first discovered in 1947 in Africa. Since then, sporadic ZIKV infections of humans have been reported in Africa and Asia. For a long time, this virus was mostly unnoticed due to its mild symptoms and low fatality rates.
Gerard Kian-Meng Goh +3 more
doaj +1 more source
ProTides for Antiviral Activity Beyond Liver Cells
Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel +5 more
wiley +1 more source
Neural Regeneration ResearchRecent increases in infectious diseases affecting the central nervous system have raised concerns about their role in neuroinflammation and neurodegeneration.
Raíssa Leite-Aguiar +4 more
doaj +1 more source