Results 111 to 120 of about 29,804,163 (234)

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Ablation of Tight Junction ZO-1 in Epithelial Cells

, 2021
The goal of this study was to create, isolate, and analyze a cell line of epithelial cells lacking the tight junction protein, ZO-1. The central hypothesis was that ZO-1 plays notable roles in permeability and proliferation and ZO-1 interaction with the ...
Peng, Lindsey Noelle
core   +1 more source

ExEn organization and permeability is abnormal in EBs lacking ZO-1 and ZO-2.

, 2014
(A) Scanning electron micrographs. ExEn apical surface morphology of WT control and ZO gene-deleted EBs was analyzed by SEM. The apical surface of compacted ExEn cells can be seen covered with dense hair-like microvilli in WT (panel a) and ZO-2-/- (panel
Adrian Boey (573783), Dominic C. Y. Phua (573781), Safiah Mohamed Ali (573782), Walter Hunziker (573785), Natalia V. Gounko (573784), Jianliang Xu (198344)   +5 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

MicroRNA-103 regulates the progression in endometrial carcinoma through ZO-1

International Journal of Immunopathology and Pharmacology, 2019
Endometrial carcinoma (EC) is one of the most common gynecological cancers in many developing countries. Although tremendous advances have been made in the diagnosis and treatment of EC, there is still no adequate biomarker currently available for ...
Jing Du, Fengli Zhang, Ling Zhang, Yueyue Jia, Huixiao Chen   +4 more
doaj   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

On the relationship between the roughness length of a scalar quantity and the corresponding sublayer-Stanton number

Meteorologische Zeitschrift, 1995
Considering Sheppard's effective diffusivity approach for the molecular-turbulent sublayer, the relationship between the roughness length of a scalar quantity, zp and the corresponding sublayer-Stanton number, Bi, ist re-formulated.
Gerhard Kramm, Hans Müller, Ralph Dlugi
doaj   +1 more source

PKP1 regulates ameloblast differentiation and ZO-1 localization.

, 2016
A, PKP1, ZO-1, Desmoplakin, and E-cadherin expressions in CLDE cells transfected with control or Pkp1 siRNA, as detected by immunocytochemistry. Nuclei were counterstained with DAPI. B, Enlarged image of disturbed ZO-1 expression following Pkp1 knockdown.
Keigo Yoshizaki (580984), Keita Funada (2580655), Masaki Ishikawa (464116), Yoshihiko Yamada (274026), Chieko Arai (2580661), Satoshi Fukumoto (715970), Kanako Miyazaki (2580658), Aya Yamada (715967), Kan Saito (715965), Ichiro Takahashi (44637), Han Xue (803892), Naoto Haruyama (487384)   +11 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source