Results 121 to 130 of about 62,010 (192)

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Heart failure pleural fluid impairs endothelial barrier through miR 501-3p mediated ZO 1 remodeling. [PDF]

iScience
Wang CY, Tiong TY, Chen Y, Lin YH, Yadav VK, Changchien CY, Chian CF, Tsai CL.   +7 more
europepmc   +1 more source

Impact of QSW‐ZVS on Input EMI Filter Design in DC‐DC Converters

International Journal of Circuit Theory and Applications, EarlyView.
This paper analyzes the impact of quasi‐square wave zero voltage switching (QSW‐ZVS) on passive EMI filter design for DC‐DC buck converters. The extra element theorem (EET) is used to derive the design quantities that ensure converter performance is not altered, and the resulting damping element values are compared with those of traditional converters.
Silvia Simone, Amirali Hosseini, Francesco Gabriele, Fabio Pareschi   +3 more
wiley   +1 more source

PAR2-β-arrestin 2-ERK axis mediates <i>Malassezia globosa</i>-induced IL-17 response by disrupting ZO-1 in keratinocytes. [PDF]

iScience
Tang J, Li F, Hong J, Li X, Zhou Y, Liu J, Fan Y.   +6 more
europepmc   +1 more source

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

ECM stiffness governs endothelial barrier integrity through YAP-mediated stabilization of ZO-1. [PDF]

Bioact Mater
Chi M, Xu X, Zhao Y, Gu S, Qu Y, Yuan B, Feng C, Tang G, Zhai Y, Peng R, Wang L, Fan Y, Hong J.   +12 more
europepmc   +1 more source

HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2. [PDF]

Sci Rep
Alvarez F, Larrous F, Mechaly A, Bardiaux B, Goor Q, Haouz A, Séon-Méniel B, de Sousa RA, Bourg S, Desmaële D, Figadère B, Wolff N, Munier-Lehmann H, Caillet-Saguy C.   +13 more
europepmc   +1 more source

Correction: The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice. [PDF]

PLoS One, 2023
Georgiadis A, Tschernutter M, Bainbridge JWB, Balaggan KS, Mowat F, West EL, Munro PMG, Thrasher AJ, Matter K, Balda MS, Ali RR.   +10 more
europepmc   +1 more source

Regulatory Effects of Ammonium Chloride in an In Vitro Model of Hepatic Encephalopathy: Mechanisms Involving ACTA2‐Mediated Cytoskeletal Remodeling

iLABMED, EarlyView.
Hyperammonemic stress suppresses ACTA2 expression and induces F‐actin cytoskeletal remodeling in astrocytes. The resulting inhibition of FAK/c‐Src signaling contributes to apoptosis, G2/M arrest, AQP4‐mediated swelling and junction‐associated proteins dysregulation, revealing a central role for ACTA2‐dependent cytoskeletal dysfunction in hepatic ...
Yue Tang, Jia Liu, Chengrong Bian, Wenwen Yuan, Wang Zhang, Fan Feng, Boan Li   +6 more
wiley   +1 more source