Results 91 to 100 of about 29,804,163 (234)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

The upregulation of lamin A/C as a compensatory mechanism during tight junction disruption in renal tubular cells mediated by calcium oxalate crystals

Current Research in Toxicology
Calcium oxalate monohydrate (COM), the most important crystal causing kidney stone disease, upregulates lamin A/C but downregulates zonula occludens-1 (ZO-1) in renal tubular cells.
Sudarat Hadpech, Paleerath Peerapen, Visith Thongboonkerd   +2 more
doaj   +1 more source

Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation.

, 2008
Apicolateral tight junctions (TJs) between epithelial cells are multiprotein complexes regulating membrane polarity and paracellular transport and also contribute to signalling pathways affecting cell proliferation and gene expression.
Nowak, Rachael L., Sheth, Bhavwanti, Anderson, Rebecca, Papenbrock, Thomas, Fleming, Tom P., Kwong, Wing Yee   +5 more
core   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection

Cell Insight
Cell polarity is crucial for gastric mucosal barrier integrity and mainly regulated by polarity-regulating kinase partitioning-defective 1b (Par1b). During infection, the carcinogen Helicobacter pylori hijacks Par1b via the bacterial oncoprotein CagA ...
Irshad Sharafutdinov, Aileen Harrer, Mathias Müsken, Klemens Rottner, Heinrich Sticht, Christian Täger, Michael Naumann, Nicole Tegtmeyer, Steffen Backert   +8 more
doaj   +1 more source

SubCon warrior 1

, 2006
Subcon Warrior 1.0 was a large-scale location based promenade performance work produced by the renowned physical theatre company Zen Zen Zo. Themed around the experiences and ethical dilemmas inherent within contemporary computer gaming scenarios it ...
Armstrong, Keith M.
core  

Understanding the mobile healthcare applications continuance: The regulatory focus perspective

, 2023
Background: Although mobile healthcare (mHealth) applications have proliferated and offer new opportunities for personal health management, many users exhibit discontinuance behavior. Various factors in mHealth applications can strongly impact users'
Hangjung Zo, Zo, Hangjung, Kyuho Han, Han, Kyuho   +3 more
core   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Luteolin attenuates Staphylococcus aureus-induced endometritis through inhibiting ferroptosis and inflammation via activating the Nrf2/GPX4 signaling pathway

Microbiology Spectrum
Endometritis, a local inflammatory disease, has been known as the most common cause of infertility in mares. In this study, we investigated the protective effects of luteolin on endometritis induced by Staphylococcus aureus (S.
Shouyang Gao, Yongjian Gao, Lifu Cai, Rui Qin   +3 more
doaj   +1 more source

ZO-1 Immunoreactivity in retinal sections.

, 2013
Co-localization of ZO-1 (green), retinal vessels (red) and nuclear staining DAPI (blue) showed marked reduction in ZO-1 expression by diabetes compared to the control.
Krishna Rao Maddipati (380135), Nasser Rizk (380137), Sylvia Megyerdi (380132), Rene Mussell (380133), Karishma Choksi (380134), Amira Othman (380131), Saif Ahmad (371052), Ahmed Elmarakby (380136), Mohamed Al-Shabrawey (380138)   +8 more
core   +1 more source