Results 71 to 80 of about 29,804,163 (234)

Subcellular Distribution of Tight Junction-Associated Proteins (Occludin, ZO-1, ZO-2) in Rodent Skin [PDF]

, 1998
Occludin is an integral membrane protein that is concentrated at tight junctions (zonulae occludentes) in simple epithelial cells. ZO-1 and ZO-2 are peripheral membrane proteins that are localized at tight junctions in simple epithelial cells and at ...
Furuse, Mikio, Morita, Kazumasa, Tsukita, Shoichiro, Ando-Akatsuka, Yuhko, Saitou, Mitinori, Itoh, Masahiko, Imamura, Sadao, Fujimoto, Kazushi, Yoneda, Kozo   +8 more
core   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

E12.5 mouse dorsal cortex, R-Ras KO, NICD OE and mInsc OE, EGFP-ZO-1, mem-CyRFP

, 2019
Additional time-lapse movies for Figure 5j,k. E12.5 mouse dorsal cortex, R-Ras KO, NICD OE and mInsc OE, EGFP-ZO-1, mem-CyRFP. Z-projection images.
Atsunori Shitamukai (7859580), Fumio Matsuzaki (131236)   +1 more
core   +1 more source

Effect of TNFα and Dex on ZO-1 expression.

, 2023
(A) Relative expression of ZO-1 mRNA in AECs after 6 h of Dex stimulation, n = 5 (five independent experiments); (B) Protein levels of ZO-1 (normalized to those of GAPDH) were measured using immunoblotting, n = 3 (three independent experiments); (C ...
Koichiro Asano (3438395), Hiroto Takiguchi (3910063), Yoko Ito (179758), Naokata Kutsuzawa (9690187), Chinatsu Kohno (9690190), Shizuko Kagawa (12188510)   +5 more
core   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Effects of ZO-1 knockout on the localization of ZO-2 and ZO-3.

, 2014
(A) Effects of ZO-1 knockout on the localization of ZO-2 in MDCK II cells. The images in Figure 1 were used for the analysis. Signal intensity of ZO-2 and ZO-1 on lines shown in confocal microscopic image (arrows) were analyzed.
Mikio Furuse (621728), Tomohito Higashi (621727), Shinsaku Tokuda (621726)   +2 more
core   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Effects of ZO-1 knockout on the localization of ZO-2, ZO-3 and occludin in the stable ZO-1 knockout clones.

, 2014
(A) Immunofluorescence microscopic analysis and line scanning of ZO-1 and ZO-2 in ZO-1 knockout clones 1 (KO 1) and 3 (KO 3) co-cultured with control cells. ZO-2 fluorescent signal at TJs was reduced in KO 1 but was slightly increased in KO 3.
Mikio Furuse (621728), Tomohito Higashi (621727), Shinsaku Tokuda (621726)   +2 more
core   +1 more source

Non‐Line‐of‐Sight Passive Ammonia Sensor Loaded With MXene/In2O3 Composites for Agricultural Products Quality Deterioration Detection

Advanced Science, EarlyView.
This study presents a flexible, battery‐free passive RFID sensing platform for NLoS monitoring of quality deterioration in fresh agricultural products. It utilizes a structurally decoupled spiral antenna‐LC electrode architecture to suppress electromagnetic interference caused by packaging.
Guoping Hu, Lin He, Fanli Meng, Daming Dong, Guolong Shi   +4 more
wiley   +1 more source