Results 71 to 80 of about 27,376,677 (317)

Chronic inflammatory demyelinating polyneuropathy: decreased claudin-5 and relocated ZO-1 [PDF]

open access: yesJournal of Neurology, Neurosurgery & Psychiatry, 2004
To clarify the dynamics of molecules composing the blood-nerve barrier (BNB) in inflammatory neuropathies.The expression of four tight junction (TJ) proteins-claudin-1, claudin-5, occludin, and ZO-1-was analysed immunohistochemically in sural nerve biopsy specimens obtained from patients with chronic inflammatory demyelinating polyradiculoneuropathy ...
T, Kanda, Y, Numata, H, Mizusawa
openaire   +2 more sources

Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus [PDF]

open access: yes, 1999
Synaptic NMDA-type glutamate receptors are anchored to the second of three PDZ (PSD-95/Discs large/ZO-1) domains in the postsynaptic density (PSD) protein PSD-95.
Apperson, Michelle   +3 more
core   +1 more source

Altered Expression of ZO-1 and ZO-2 in Sertoli Cells and Loss of Blood-Testis Barrier Integrity in Testicular Carcinoma In Situ

open access: yesNeoplasia: An International Journal for Oncology Research, 2006
Carcinoma in situ (CIS) is the noninvasive precursor of most human testicular germ cell tumors. In normal seminiferous epithelium, specialized tight junctions between Sertoli cells constitute the major component of the blood-testis barrier. Sertoli cells
Cornelia Fink   +6 more
doaj   +1 more source

Serum Zonulin Measured by Commercial Kit Fails to Correlate With Physiologic Measures of Altered Gut Permeability in First Degree Relatives of Crohn's Disease Patients

open access: yesFrontiers in Physiology, 2021
Intestinal epithelial cell tight junctions (TJs) contribute to the integrity of the intestinal barrier allowing for control of the physical barrier between external antigens or bacterial products and the internal environment. Zonula occludens-1 (ZO-1) is
Namita Power   +10 more
doaj   +1 more source

Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling. [PDF]

open access: yes, 2018
BACKGROUND:Human cerebral malaria (HCM) is a severe form of malaria characterized by sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of circulating free heme and pro-inflammatory cytokines and chemokines, brain ...
Cespedes, Juan Carlos   +5 more
core   +1 more source

Quantitative understanding of HepaRG cells during drug‐induced intrahepatic cholestasis through changes in bile canaliculi dynamics

open access: yesPharmacology Research & Perspectives, 2022
An understanding of the quantitative relationship between bile canaliculus (BC) dynamics and the disruption of tight junctions (TJs) during drug‐induced intrahepatic cholestasis may lead to new strategies aimed at drug development and toxicity testing ...
Rie Sonoi, Yoshihisa Hagihara
doaj   +1 more source

Zonula occludens 2 and Cell-Cell Contacts Are Required for Normal Nuclear Shape in Epithelia

open access: yesCells, 2021
MAGUK protein ZO-2 is present at tight junctions (TJs) and nuclei. In MDCK ZO-2 knockdown (KD) cells, nuclei exhibit an irregular shape with lobules and indentations.
Christian Hernández-Guzmán   +4 more
doaj   +1 more source

Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1

open access: yesMolecular Biology of the Cell, 2017
GFP claudins (cldns) make dynamic strand patches between fibroblasts regulated by ZO-1 binding. Independent of ZO-1, cldn strands break and reanneal; new cldns are preferentially incorporated into break sites.
C. V. Van Itallie   +2 more
semanticscholar   +1 more source

The Unique-5 and -6 Motifs of ZO-1 Regulate Tight Junction Strand Localization and Scaffolding Properties [PDF]

open access: yes, 2006
The proper cellular location and sealing of tight junctions is assumed to depend on scaffolding properties of ZO-1, a member of the MAGUK protein family. ZO-1 contains a conserved SH3-GUK module that is separated by a variable region (unique-5), which in
Anderson, James M.   +5 more
core  

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