Results 141 to 150 of about 59,731 (190)

Windows of opportunity in subseasonal weather regime forecasting: A statistical–dynamical approach

Quarterly Journal of the Royal Meteorological Society, EarlyView.
This study explores how the atmospheric state at initialisation creates windows of opportunity for improving week 3 forecasts of weather regime activity. Greenland blocking activity increases following Madden–Julian Oscillation phases 7, 8, and 1 and weak stratospheric polar vortex states, revealing patterns exploitable by statistical models.
Fabian Mockert, Christian M. Grams, Sebastian Lerch, Julian Quinting   +3 more
wiley   +1 more source

Exceptionally poor and good medium‐range forecasts of the large‐scale circulation over Europe in ERA5 reforecasts

Quarterly Journal of the Royal Meteorological Society, EarlyView.
This study investigates year‐round exceptionally poor and good day‐6 forecasts of the 500‐hPa geopotential height field over Europe using 45 years of ERA5 reforecasts and applies a weather regime perspective to analyse large‐scale pattern evolution and regime transitions.
Seraphine Hauser, Steven M. Cavallo, Linus Magnusson, Jonathan E. Martin, David B. Parsons   +4 more
wiley   +1 more source

Triptolide decreases podocytes permeability by regulating TET2-mediated hydroxymethylation of ZO-1. [PDF]

Exp Biol Med (Maywood)
Tang YW, Jiang MY, Cao JW, Wan F.
europepmc   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner. [PDF]

Int J Biol Sci
Yang X, Shen X, Liu Z, Li Y, Liu H, Zhan Y, Liu Y, Liang C, Zhao L, Zhang X, Huang Y, Shen W.   +11 more
europepmc   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source

Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border. [PDF]

Cell Commun Signal
Wang K, Qu H, Hu R, Lassègue B, Eaton DC, Song C, Mu J, Griendling KK, Hernandes MS.   +8 more
europepmc   +1 more source

Enhancing the Chemical Reactivity of Graphene through Substrate Engineering

Small, EarlyView.
This review highlights methods to enhance the reactivity of graphene through substrate engineering, focusing on strain and charge doping. Strains induced by nanoparticles, metal crystal orientations, or stretchable polymers increase the reactivity of graphene.
Jia Tu, Mingdi Yan
wiley   +1 more source

Annexin A1 Mitigates Blood-Brain Barrier Disruption in a Sepsis-Associated Encephalopathy Model by Enhancing the Expression of Occludin and Zonula Occludens-1 (ZO-1). [PDF]

CNS Neurosci Ther
Li Y, Zhou F, You J, Gong X.
europepmc   +1 more source

Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation

Small, EarlyView.
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul, Cédric Bergerbit, Iulia Scarlat, Teodora Piskova, Vasudha Turuvekere Krishnamurthy, Aleksandra N. Kozyrina, Stacy Lok Sze Yam, Laura De Laporte, Jacopo Di Russo   +8 more
wiley   +1 more source