Results 151 to 160 of about 62,010 (192)

Triptolide decreases podocytes permeability by regulating TET2-mediated hydroxymethylation of ZO-1. [PDF]

Exp Biol Med (Maywood)
Tang YW, Jiang MY, Cao JW, Wan F.
europepmc   +1 more source

HucMSC‐Derived Exosomes Preserve Mafb‐Dependent Tubular Epithelial Identity and Suppress Dedifferentiation in Obstructive Nephropathy

Pediatric Discovery, EarlyView.
Unilateral ureteral obstruction (UUO) and genetic deletion of Mafb lead to tubular epithelial dedifferentiation, characterized by decreased E‐cadherin and increased α‐SMA and vimentin expression. Intravenous administration of human umbilical cord mesenchymal stem cell‐derived exosomes (HucMSC‐Exos) partially restores Mafb expression in UUO kidneys ...
Zhuocheng Shi, Chenxi Jia, Meiling Chen, Yihang Yu, Deying Zhang, Guanghui Wei   +5 more
wiley   +1 more source

TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner. [PDF]

Int J Biol Sci
Yang X, Shen X, Liu Z, Li Y, Liu H, Zhan Y, Liu Y, Liang C, Zhao L, Zhang X, Huang Y, Shen W.   +11 more
europepmc   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border. [PDF]

Cell Commun Signal
Wang K, Qu H, Hu R, Lassègue B, Eaton DC, Song C, Mu J, Griendling KK, Hernandes MS.   +8 more
europepmc   +1 more source

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

Phytotherapy Research, EarlyView.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang, YongJun Du, Yanmei Hou, Liangliang Hao, Zhen Chen, Haoyang Xie, Chuantao Zhang, Lei Li   +7 more
wiley   +1 more source

Annexin A1 Mitigates Blood-Brain Barrier Disruption in a Sepsis-Associated Encephalopathy Model by Enhancing the Expression of Occludin and Zonula Occludens-1 (ZO-1). [PDF]

CNS Neurosci Ther
Li Y, Zhou F, You J, Gong X.
europepmc   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization. [PDF]

Elife
Lee HC, Park SH, Jeong HM, Shin G, Lim SI, Kim J, Shim J, Park YM, Song KS.   +8 more
europepmc   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source