A fixed combination of probiotics and herbal extracts attenuates intestinal barrier dysfunction from inflammatory stress in an in vitro model using Caco-2 cells. [PDF]
, 2019 Background: Inflammatory Bowel Diseases (IBD), are considered a growing global disease, with about ten million people being affected worldwide. Maintenance of intestinal barrier integrity is crucial for preventing IBD onset and exacerbations. Some recent
Biagi, M +8 more
core +1 more source
Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. [PDF]
, 2006 OBJECTIVE: Little is known about the interaction of gliadin with intestinal epithelial cells and the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We investigated whether gliadin has any immediate effect on zonulin release
Carroccio A +13 more
core +1 more source
Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin [PDF]
, 2006 Epithelial tight junctions participate in the regulation of gene expression by controlling the activity of transcription factors that can interact with junctional components.
Balda, MS +6 more
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Roles of claudin-2, ZO-1 and occludin in leaky HK-2 cells. [PDF]
PLoS ONE, 2017 Claudin-2, ZO-1, and occludin are major components of tight junctions (TJs) in the proximal tubule. However, their roles in maintaining paracellular permeability as leaky epithelia have yet to be defined.To investigate the contributory role of TJ ...
Sua Kim, Gheun-Ho Kim
doaj +1 more source
Cells, 2022 Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell–cell junction assembly. Here, we combined methods to modulate ECM stiffness and to measure mechanical forces on adhesion complexes to investigate how tight ...
Alexis J. Haas +8 more
doaj +1 more source
Allosteric Activation of the Par-6 PDZ Via a Partial Unfolding Transition [PDF]
, 2013 Proteins exist in a delicate balance between the native and unfolded states, where thermodynamic stability may be sacrificed to attain the flexibility required for efficient catalysis, binding, or allosteric control.
Kovrigin, Evgeni L. +3 more
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Junctional Adhesion Molecule-C Mediates the Recruitment of Embryonic-Endothelial Progenitor Cells to the Perivascular Niche during Tumor Angiogenesis [PDF]
, 2020 The homing of Endothelial Progenitor Cells (EPCs) to tumor angiogenic sites has been described as a multistep process, involving adhesion, migration, incorporation and sprouting, for which the underlying molecular and cellular mechanisms are yet to be ...
Bieback, Karen +6 more
core +1 more source
Localization of ZO-1 in the Nucleolus of Corneal Fibroblasts
Investigative Opthalmology & Visual Science, 2007 Within the multidomain structure of ZO-1 are motifs responsible for ZO-1's localization to intercellular junctions and its newly demonstrated localization to the leading edge of lamellipodia in corneal fibroblasts. Since ZO-1 also has two nuclear localization signals, this study was undertaken to determine whether stimuli associated with wounding would
Miriam, Benezra +2 more
openaire +2 more sources
Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells [PDF]
, 2019 Intestinal epithelial barrier function in celiac disease (CeD) patients is altered. However, the mechanism underlying this effect is not fully understood.
Branchi, Federica +6 more
core +1 more source
ZO-1: Lamellipodial Localization in a Corneal Fibroblast Wound Model
Investigative Opthalmology & Visual Science, 2005 To explore the roles of ZO-1 in corneal fibroblasts and myofibroblasts in a model of wounding.Antibodies were used to identify ZO-1 in cultured rabbit corneal fibroblasts by immunocytochemistry, Western blot analysis, and immunoprecipitation. For colocalization studies, antibodies to beta-catenin, cadherins, connexins, integrins, alpha-actinin, and ...
Lavinia, Taliana +4 more
openaire +2 more sources