Results 211 to 220 of about 67,145 (262)

Periodontitis promotes intestinal inflammation through gut microbiota-mediated suppression of GPR109A. [PDF]

Front Cell Infect Microbiol
Wang X, Xu Z, Yao Y, Jia H, Du M, Wang S, Yan F, Li L.   +7 more
europepmc   +1 more source

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

Netrin-5 Preserves Blood-Brain Barrier Integrity via Wnt3a/β-Catenin Pathway Activation in Murine Cerebral Ischemia. [PDF]

Transl Psychiatry
Chen Y, Liu L, Ming Y, Peng L, Chen L.
europepmc   +1 more source

ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation

ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation
A fundamental question in cell and developmental biology is how epithelial cells construct the diffusion barrier allowing them to separate different body compartments. Formation of tight junction (TJ) strands, which are crucial for this barrier, involves the polymerization of claudins, TJ adhesion molecules, in temporal and spatial manners. ZO-1 and ZO-
openaire  

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

OMPB: An Omnidirectional-Mobile Paddle Boat Designed for Narrow Water Areas. [PDF]

Sensors (Basel)
Gan Z, Huang Z, Deng B, Gong H.
europepmc   +1 more source

PFAS from a Discrete‐Event Terrestrial Source Migrates with Groundwater to Intertidal Seepages

Groundwater, EarlyView.
PFAS is conveyed to the coastal intertidal zone from sources across the terrestrial landscape. Discharge of PFAS into the coastal ecosystem is complicated in space and time by the ongoing bi‐directional exchange of terrestrial groundwater and ocean water driven by tidal pumping within discharge areas.
Martin A. Briggs, Eric A. White, Patrick T. Scordato, Hayley G. Lind, Zachary O. O'Neal, David M. Rey, Timothy D. McCobb, Christopher T. Green, Denis R. LeBlanc   +8 more
wiley   +1 more source

Erythropoietin preserves outer blood-retinal barrier integrity in diabetic retinopathy via AMPK-dependent autophagy and Nrf2 signaling. [PDF]

J Cereb Blood Flow Metab
Jang HY, Jiang H, Park JJ, Wu J, Jiang W, Kim JH.   +5 more
europepmc   +1 more source

High prevalence of loss of Claudin‐18 expression in invasive non‐mucinous lung adenocarcinoma: Potential diagnostic implications in routine practice

Histopathology, EarlyView.
Loss of Claudin‐18 (Cldn18) expression is a frequent and specific feature of non‐mucinous lung adenocarcinoma (NM‐LUAD). Cldn18 immunohistochemistry may serve as an ancillary tool for distinguishing malignant from non‐neoplastic alveolar epithelium, as well as for differentiating NM‐LUADs with mucin production from M‐LUADs, particularly in small or ...
Stefano Lucà, Marco Montella, Mario Fordellone, Riccardo Monti, Maria Giulia Disanto, Giuseppa Zannini, Marina Accardo, Maria Ali, Gaetano Di Guida, Carminia Maria Della Corte, Beatrice Leonardi, Severo Campione, Valerio Nardone, Floriana Morgillo, Alfonso Fiorelli, Luisella Righi, Mattia Barbareschi, Luka Brcic, Renato Franco   +18 more
wiley   +1 more source