Results 1 to 10 of about 8,358 (142)

Phase II pilot randomized trial of zonisamide for disease modification in prodromal Lewy body disease [PDF]

npj Parkinson's Disease
Zonisamide exhibits potential neuroprotective properties, but its efficacy during the prodromal stage of Lewy body disease (LBD) remains unclear. In this phase II randomized, double-blind pilot trial, 29 high-risk individuals aged 50–80 years with ≥2 ...
Keita Hiraga, Makoto Hattori, Daigo Tamakoshi, Yuki Satake, Taiki Fukushima, Yuki Saito, Takashi Uematsu, Takashi Tsuboi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Yoshino Ueki, Fumie Kinoshita, Hiroshi Matsuda, Akihiro Murata, Masayuki Yamamoto, Masakazu Wakai, Noriyuki Matsukawa, Yukihiko Washimi, Masahisa Katsuno   +20 more
doaj   +2 more sources

Zonisamide

Reactions Weekly, 2006
europepmc   +3 more sources

Distal renal tubular acidosis and lethargy associated with zonisamide treatment in a dog with idiopathic epilepsy

Veterinary Medicine and Science, 2022
A 3‐year‐old neutered male golden retriever administered zonisamide for the treatment of seizures showed lethargy and had normal anion gap metabolic acidosis with hypokalaemia, hyperchloremia, and alkaline urine.
Takamasa Itoi, Natsuki Akashi, Yuki Shimizu, Keisuke Sugimoto, Akihisa Hata, Kenji Kutara, Takako Shimokawa Miyama, Teppei Kanda   +7 more
doaj   +1 more source

Incidence of hepatopathies in dogs administered zonisamide orally: A retrospective study of 384 cases

Journal of Veterinary Internal Medicine, 2022
Background Acute hepatopathy secondary to administration of zonisamide has been reported in 2 dogs, but overall incidence of hepatopathy is unknown. Objective To characterize the incidence of hepatopathy in dogs administered zonisamide PO.
Tess K. Smith, Starr Cameron, Lauren A. Trepanier   +2 more
doaj   +1 more source

Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model. [PDF]

PLoS ONE, 2015
No clinically applicable drug is currently available to enhance neurite elongation after nerve injury. To identify a clinically applicable drug, we screened pre-approved drugs for neurite elongation in the motor neuron-like NSC34 cells.
Hideki Yagi, Bisei Ohkawara, Hiroaki Nakashima, Kenyu Ito, Mikito Tsushima, Hisao Ishii, Kimitoshi Noto, Kyotaro Ohta, Akio Masuda, Shiro Imagama, Naoki Ishiguro, Kinji Ohno   +11 more
doaj   +1 more source

Zonisamide Ameliorates Microglial Mitochondriopathy in Parkinson’s Disease Models

Brain Sciences, 2022
Mitochondrial dysfunction and exacerbated neuroinflammation are critical factors in the pathogenesis of both familial and non-familial forms of Parkinson’s disease (PD).
Satoshi Tada, Mohammed E. Choudhury, Madoka Kubo, Rina Ando, Junya Tanaka, Masahiro Nagai   +5 more
doaj   +1 more source

Intraoperative acidosis related to chronic zonisamide therapy. [PDF]

Pediatric Anesthesia and Critical Care Journal (PACCJ), 2021
Zonisamide is a novel anticonvulsant agent used in the treatment of partial and generalized seizures in children and adults. In addition to its anticonvulsant effects, zonisamide inhibits carbonic anhydrase and may result in a chronic, non-anion gap ...
A. G. Mohr, K. Moon, A. Alpern, A. D’Mello, J. D. Tobias   +4 more
doaj   +1 more source

Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report

Frontiers in Veterinary Science, 2021
Psychiatric adverse effect associated with anti-seizure drugs has been well-recognized in human medicine. This case report describes three dogs with presumptive idiopathic epilepsy presented for abnormal behavior episodes.
Shinichi Kanazono, Shinichi Kanazono, Masayasu Ukai, Masayasu Ukai, Akira Hiramoto   +4 more
doaj   +1 more source

Limited efficacy of zonisamide in the treatment of refractory infantile spasms

Epilepsia Open, 2020
A series of relatively small studies collectively suggest that zonisamide may be effective in the treatment of infantile spasms. Using a large single‐center cohort of children with infantile spasms, we set out to evaluate the efficacy and safety of ...
Shaun A. Hussain, Mario Navarro, Jaeden Heesch, Matthew Ji, Brenda Asilnejad, Haley Peters, Rajsekar R. Rajaraman, Raman Sankar   +7 more
doaj   +1 more source

Pharmacokinetics of zonisamide after oral single dosing and multiple‐dose escalation administration in domestic chickens (Gallus gallus)

Veterinary Medicine and Science, 2021
Background There are few effective drugs for treatment of seizures in avian species. Objectives To investigate the pharmacokinetics and safety of zonisamide in chickens. Methods Phase 1: chickens (n = 4) received a single oral dose of zonisamide at 20 mg/
Ricardo deMatos, Brendan P. Noonan, Deanna M.W. Schaefer, James Morrisey, Curtis Dewey, Elizabeth L. Buckles, Dawn Boothe   +6 more
doaj   +1 more source