Results 51 to 60 of about 12,742 (223)

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Bioequivalence of Different Formulations of Zonisamide Oral Suspensions: A Short Review

Patient Preference and Adherence, 2023
Ivana Stević,1 Nemanja Petrović,2 Slobodan M Janković2 1Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia; 2Faculty of Medical Sciences, University of Kragujevac, Kragujevac, SerbiaCorrespondence: Slobodan M Jankovi ...
Stević I, Petrović N, Janković SM
doaj  

Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs

Health Technology Assessment, 2021
Background: Levetiracetam (Keppra®, UCB Pharma Ltd, Slough, UK) and zonisamide (Zonegran®, Eisai Co. Ltd, Tokyo, Japan) are licensed as monotherapy for focal epilepsy, and levetiracetam is increasingly used as a first-line treatment for generalised ...
Anthony G Marson, Girvan Burnside, Richard Appleton, Dave Smith, John Paul Leach, Graeme Sills, Catrin Tudur-Smith, Catrin O Plumpton, Dyfrig A Hughes, Paula R Williamson, Gus Baker, Silviya Balabanova, Claire Taylor, Richard Brown, Dan Hindley, Stephen Howell, Melissa Maguire, Rajiv Mohanraj, Philip EM Smith   +18 more
doaj   +1 more source

Safety and efficacy of cannabidiol-cannabidiolic acid rich hemp extract in the treatment of refractory epileptic seizures in dogs

Frontiers in Veterinary Science, 2022
The use of cannabidiol (CBD) in childhood refractory seizures has become a common therapeutic approach for specific seizure disorders in human medicine.
Gabriel A. Garcia, Stephanie Kube, Sheila Carrera-Justiz, David Tittle, Joseph J. Wakshlag   +4 more
doaj   +1 more source

The Use of Antiepileptic Drugs (AEDs) for the Treatment of Pediatric Aggression and Mood Disorders [PDF]

, 2014
Aggressive symptomatology presents across multiple psychiatric, developmental, neurological and behavioral disorders, complicating the diagnosis and treatment of the underlying pathology.
Ducharme, Peter, Gonzalez-Heydrich, Joseph, Guild, Danielle J., Munshi, Kaizad R., Oken, Tanya, Trivedi, Harsh K., Wang, Betty C.   +6 more
core   +1 more source

Immune‐mediated polyarthritis and anterior uveitis secondary to zonisamide administration in a dog with refractory epilepsy

Veterinary Medicine and Science
The objective of this article is to describe a case of suspected zonisamide‐induced immune‐mediated polyarthritis (IMPA) and anterior uveitis in a dog.
Paula Baya, Saya Press, Stephanie Istvan, Kaila Rizzo   +3 more
doaj   +1 more source

Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review. [PDF]

, 2016
Antiepileptic drugs (AEDs) have many benefits but also many side effects, including aggression, agitation, and irritability, in some patients with epilepsy.
Alan B. Ettinger, Albert P. Aldenkamp, Bernhard J. Steinhoff, Besag, Biton, Brodkin, Brown, Carmichael, Chiaretti, Coccaro, Cánovas Martínez, David R. Sibley, Delgado-Escueta, Devinsky, Dolton, D’Souza, Edwards, Elliott, Ettinger, Feindel, Flor-Henry, Frank Besag, Friedman, Gabriella Gobbi, Gedye, Gobbi, Gollan, Hemming, Huband, Jan, Kang, Klüver, Krishnamoorthy, Kugaya, Lander, Landolt, Lee, LoPresti, Loup, Maletzky, Maletzky, Marco Mula, Martin J. Brodie, Mpakopoulou, Mula, Olsen, Pandya, Ratner, Raucci, Robinson, Ruuskanen, Schmitz, Seidenwurm, Shehata, Silver, Stefano Comai, Steinhoff, Szczurowska, Turski, Van Paesschen, Wieshmann   +60 more
core   +3 more sources

Self‐limited neonatal epilepsy with 2q24.3 duplications: Case series and literature review

Epileptic Disorders, EarlyView.
Abstract Objective To clarify the phenotypic spectrum associated with duplications involving the 2q24.3 region, which includes a cluster of genes encoding sodium channel subunits (SCN1A, SCN2A, SCN3A, SCN7A, and SCN9A). Methods We reviewed our research database for patients with epilepsy and 2q24.3 duplication and performed thorough phenotyping.
Saba Al Rawahi, Kenneth A. Myers
wiley   +1 more source

Migraine treatment in developmental age: guidelines update [PDF]

, 2010
There is a serious lack of controlled studies on the pharmacological treatment of primary migraine in the developmental age; there is, consequently, an urgent need for new, evidence-based approaches to this long-neglected field of research.
Alberto Spalice, Francesco Nicita, Laura Papetti, Maria Chiara Paolino, Maria Pia Villa, Paola Iannetti, Pasquale Parisi, Rosa Castaldo   +7 more
core   +4 more sources

Mechanisms of SCN2A loss of function do not predict presence or phenotype of epilepsy

Epilepsia, EarlyView.
Abstract Objective SCN2A loss‐of‐function (LoF) variants are associated with epilepsy (onset age ≥ 3 months), intellectual disability (ID), and autism spectrum disorder (ASD). Despite numerous identified variants and the description of phenotypic subgroups, relationships between Nav1.2 channel dysfunction and clinical phenotypes remain unclear.
Marsha Tan, Beatrice Southby Goad, Meagan Allen, Jill Rodda, Kay L. Richards, Simone L. Ardern‐Holmes, Daniel Bamborschke, Daniel Fritzen, Inna Hughes, Kate Riney, Ana Roche Martinez, Angelo Russo, Adriane Sinclair, Stefano Sartori, Marina Trivisano, Angela De Dominicis, Nicola Specchio, Rikke S. Møller, Ingrid E. Scheffer, Walid Fazeli, Markus Wolff, Steven Petrou, Katherine B. Howell, Géza Berecki   +23 more
wiley   +1 more source